Development of New Organoiodine-Catalyzed Reactions and Their Applications in Synthetic Chemistry
| Project/Area Number |
16K08186
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
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| Research Collaborator |
China Hideyasu
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 合成化学 / グリーンケミストリー |
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| Outline of Final Research Achievements |
In this research, we have developed several new hypervalent iodine compounds that can more effectively catalyze the metal-free oxidative couplings reported by us. Compared with the synthetic methods using metal catalysts that can generally perform the bond formation by compensation of the functional group, our method has significant advantage in obtaining the coupling products remaining more functional groups. Utilizing this characteristics, we have extended our synthetic strategy to apply the obtained compounds as the useful precursors for natural products with highly oxygenated aromatic rings as well as some functional molecules.
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| Academic Significance and Societal Importance of the Research Achievements |
酸化反応は炭素－水素結合を直接、結合形成や官能基化に用いるといった点で魅力的な合成戦略であり、グリーンケミストリーの理念に合致している。最近、芳香族化合物の炭素－水素結合を直接、酸化的カップリングさせる反応が実現し、医薬品や機能性材料の新規合成戦略として注目を集めている。希少なレアメタル触媒の使用が必要であった本法を、有機ヨウ素触媒を用いて行うことを可能とする本研究成果は、学術的のみならず社会的にも大きな波及効果をもたらすことが期待できる。
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Report
(4 results)
Research Products
(110 results)
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[Journal Article] Atropisomeric chiral diiododienes, (Z,Z)-2,3-di(1-iodoalkylidene)tetralins: Synthesis, enantiomeric resolution, and application in asymmetric catalysis2017
Author(s)
M. Ogasawara, H. Sasa, H. Hu, Y. Amano, H. Nakajima, N. Takenaga, K. Nakajima, Y. Kita, T. Takahashi, T. Dohi
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Journal Title
Org. Lett.
Volume: 19
Issue: 15
Pages: 4102-4105
DOI
NAID
Related Report
Peer Reviewed / Open Access
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