| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The purpose of this study is the precise perdition of destabilization kinetics of a pharmaceutical emulsion. Magnetic resonance imaging (MRI) and time-temperature superposition principle (TTSP) are cited as a key technology of this study. MRI is a popular molecular imaging method based on the principle of NMR, while TTSP is one of the most useful extrapolation techniques based on the Arrhenius approach. The state of sample emulsions was monitored using magnetic resonance imaging, and then the phase separation behaviors were analyzed by TTSP. This study succeeded in demonstrating these technologies were powerful for this purpose. It enables us to perform a kinetic analysis based on the Arrhenius methodology precisely. This technique can be applied to a wide range of pharmaceutical properties. Thus, we believe the breakthrough findings of this study will bring about great benefits for pharmaceutical research.
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