| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Small interfering RNA (siRNA) capable of inducing gene silencing is a promising drug candidate to address unmet medical needs. However, siRNA is difficult to induce gene silencing without an appropriate delivery vehicle. The establishment of effective delivery systems is one of the most important tasks to develop RNA interference (RNAi)-based drugs. Functional lipid nanoparticles are attractive and promising vectors for RNAi therapy. In the present study, we developed novel lipid nanoparticles containing a possible RNAi enhancer for cancer treatment. Our findings provide new insights into the design of effective lipid nanoparticles for RNAi therapy.
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