| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The aim of this study was to develop an imaging method of primary particles of active pharmaceutical ingredients (API) in formulations by Raman crystal orientation mapping (RCOM) method. Raman spectrum is determined based on the angle between the polarization direction of excitation laser and the crystal axes; therefore, the spectral transition is observed on the boundary of the primary particles of the API, which forms the concept of RCOM. We applied this technique to visualize the primary particles in the formulations using phenytoin and cilostazol as the model API. Also, we performed dissolution tests for model tablets of phenytoin and cilostazol and revealed the relationship between the primary particle morphology and the dissolution rate. We believe that the application of the RCOM method would facilitate visualization of the primary particles of various APIs in a formulation for the better understanding of the dissolution behavior of the formulation.
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