| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In neuronal presynaptic sites, neurotransmitter release is triggered by voltage-gated calcium channels (VGCC) and supported by unique basal structures with a group of adaptor proteins. In this study, we analyzed the molecular mechanism of protein localization to presynaptic sites focusing on the relationship between VGCC and the adapter molecule RIMB-1/RIM-BP in C. elegans, an invertebrate model animal. We revealed that the localization of VGCC is mainly regulated by the redundant function of two adaptor molecules, RIMB-1 and UNC-10. Moreover, we identified the requirement of VGCC and endocytic proteins for the localization of RIMB-1.
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