| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
FoxA1 is a pioneer factor that regulates chromatin remodeling and gene expression. FoxA1 is known to be involved in breast cancer progression through expression of genes controlling cell survival and growth. However, FoxA1 expression is reduced or lost in malignant types of breast cancer cells, and the relationship between the presence of FoxA1 expression and the malignancy of breast cancer cells has not been clarified. In this study, we found that loss of FoxA1 expression causes acquisition of chemo-resistance in breast cancer cells. This finding suggests that FoxA1 has both promotive and suppressive roles in breast cancer progression. Specific inhibition of its promotive roles in breast cancer progression is required for the treatment of breast cancer patients.
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