Proinflammatory activity elicited by oxidized low-density lipoproteins and neutrophil extracellular trap formation
| Project/Area Number |
16K08245
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Showa University |
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Principal Investigator |
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| Research Collaborator |
ITABE Hiroyuki (30203079)
IWAMOTO Sanju (50176567)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 好中球 / 酸化LDL / リポタンパク質 / 動脈硬化 / 血管炎症 / 動脈硬化症 |
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| Outline of Final Research Achievements |
We investigated the effects of oxidized low-density lipoprotein (oxLDL) on neutrophil extracellular trap (NET) formation using HL-60-derived neutrophils. OxLDL, but not native LDL, enhanced PMA-induced NET formation with enhanced release of myeloperoxidase into the culture media, leading to elongation of human aortic endothelial cells and increased inflammatory responses. These data suggest that oxLDL may play important roles in exacerbating endothelial functions through accelerating NET formation.
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| Academic Significance and Societal Importance of the Research Achievements |
血中コレステロールの中でも超悪玉として知られる酸化LDLは、血管内での脂質蓄積や血管炎症を引き起こす危険因子であることが知られている。血液中の白血球の多くを占める好中球は生体防御において重要な働きをするが、過度に活性化すると組織傷害を引き起こす。本研究は好中球の活性化に対する酸化LDLの影響について調べた。酸化LDLは好中球の活性化を促進して血管内皮細胞の炎症応答を増悪させることが示唆され、動脈硬化および血管炎症が進行する際の新しいメカニズムが存在する可能性が考えられた。
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Quantitative proteomic analysis of gingival crevicular fluids from deciduous and permanent teeth.2017
Author(s)
Moriya Y, Obama T, Aiuchi T, Sugiyama T, Endo Y, Koide Y, Noguchi E, Ishizuka M, Inoue M, Itabe H, Yamamoto M.
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Journal Title
Journal of Clinical Periodontology
Volume: 印刷中
Issue: 4
Pages: 353-362
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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