| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Although Tfh cells are crucial for the humoral immune response, there are no tools to track the fate of Tfh cells. In this study, we generated two reporter mice that enables Tfh cell tracking in vivo. Using these reporter mice, we demonstrated that Tfh cells could be tracked from the effector phase to the memory phase. During the contraction phase, the localization of Tfh cells changed from B cell follicles and GC areas to T-B border areas and T cell zones. These results indicate that these mice are useful tools for studying the cell fate of differentiated Tfh cells in vivo and therefore have implications for the development of therapeutic strategies for infectious and autoimmune diseases.
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