| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Accumulating the lines of evidence suggest that breast cancer subtype might change from the primary tumor to the recurrence. Since the subtype and receptor status are critical factors for the consideration of the cancer treatment, it is important to understand the molecular mechanism of the subtype discordance. However, the experimental conditions of subtype discordance are still reminded to be established.
In the present study, using the breast cancer cell lines expressing estrogen receptor (ER) that is one of the hormone receptors, we succeeded in the establishment of the cell culture method where down-regulation of estrogen receptor was observed. We also established the bone metastatic cell lines. Because bone metastasis is often associated with the recurrence of ER positive breast cancer patient. Our results might contribute the understanding of the molecular mechanism for the subtype discordance and improve the treatment of breast cancer patients.
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