Study on the novel post translational modification of AMPK aimed at comprehensive prevention and treatment of complex metabolic disorders
| Project/Area Number |
16K08273
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MIYAMOTO Licht 徳島大学, 大学院医歯薬学研究部(薬学域), 助教 (60456887)
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| Research Collaborator |
UMEMOTO Kana
UESHIMA Sayaka
TOMOKAWA Goki
TSUCHIYA Koichiro
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | AMPK / エネルギー代謝制御 / メタボリックシンドローム / 細胞内情報伝達 / 代謝疾患 |
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| Outline of Final Research Achievements |
We found a novel post translational modification of AMPK responsive to food intake and have determined intra- as well as inter-cellular signaling mechanisms regulating the modulation, which suggests AMPK as a metabolic intersection where metabolic signals evoked by physical exercise and food intake crosstalk.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により糖尿病や肥満、メタボリックシンドロームなどの複合的代謝疾患を予防、治癒しうる標的分子であるAMPKの新たな活性制御機構や生理学的意義が明らかとなり、新たな代謝疾患治療薬の創薬に繋がることが期待される。さらに、高齢化社会において増加が見込まれる神経変性疾患やガンなどに対する予防、治療戦略の構築にも有益であり、身体運動や食事療法の健康向上効果の一部を模倣可能な薬物の創出にも重要な情報がもたらされた。現在これらの情報を元に、AMPK活性を制御する一連の新たな化合物を見出し、構造展開を進めている。
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Mechanisms of the pH- and Oxygen-Dependent Oxidation Activities of Artesunate2018
Author(s)
Tsuda K, Miyamoto L, Hamano S, Morimoto Y, Kangawa Y, Fukue C, Kagawa Y, Horinouchi Y, Xu W, Ikeda Y, Tamaki T, Tsuchiya K
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Journal Title
Biological and Pharmaceutical Bulletin
Volume: 41
Issue: 4
Pages: 555-563
DOI
NAID
ISSN
0918-6158, 1347-5215
Related Report
Peer Reviewed / Open Access
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[Presentation] A limonene-derivative purified from peels of Citrus Sudachi ameliorates lipid and glucose metabolism through upregulating sirt1.2018
Author(s)
Licht Miyamoto, Haruna Aihara, Wenting Xu, Meina Jin, Yosuke Tomida, Tomomi Yamaoka, Naonobu Tanaka, Yasumasa Ikeda, Toshiaki Tamaki, Yoshiki Kashiwada, Koichiro Tsuchiya
Organizer
World Congress on Pharmacology
Related Report
Int'l Joint Research
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