| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Portal hypertension is a major complication in patients with chronic liver diseases and cirrhosis, but its pathogenic mechanism remains unclear. Here, we demonstrate that, in portal hypertensive mice, 1) expression of calcium-activated chloride channel TMEM16A is downregulated, 2) calcium-activated chloride currents are reduced, and 3) component of TMEM16A-mediated contraction is attenuated. These results suggest that TMEM16A is involved in the molecular mechanism of the development of portal hypertension.
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