| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Atopic dermatitis is a chronic inflammatory skin disease. In this study, we examined the role of IL-22 in the antigen-induced skin lesions in mice. BALB/c mice were repeatedly challenged with Dermatophagoides farinae (Der f) applied to the right ear nine times. Treatment with anti-IL-22 mAb inhibited the development of Der f-induced ear swelling. Furthermore, recombinant IL-22 emhanced the development of Der f-induced ear swelling. Collectively, we revealed that IL-22 is a key contributor to the development of Der f-induced skin lesions.
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