Evaluation of complementary and alternative medicinal resources and their bio-functional ingredients based on pharmaceutical food sciences
Project/Area Number |
16K08313
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Natural medicines
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Research Institution | Kindai University |
Principal Investigator |
MURAOKA Osamu 近畿大学, 薬学総合研究所, 客員教授 (20142599)
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Co-Investigator(Kenkyū-buntansha) |
森川 敏生 近畿大学, 薬学総合研究所, 教授 (10340449)
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Research Collaborator |
TANABE genzoh
NINOMIYA kiyofumi
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | サラシア / チオ糖スルホニウム化合物 / α-グルコシダーゼ阻害活性 / 癌転移抑制活性 / PPARγアゴニスト / hikiamide / amorfrutin C / 抗がん薬シーズ / pseudo-amorfrutin A / biakamide / ACA-28 / キサントン配糖体 / mangiferin / 癌転移抑制作用 / アポトーシス誘導活性 / 補完代替医療素材 / 食品薬学 / メタボリックシンドローム / 食品 / 薬学 |
Outline of Final Research Achievements |
To explore new therapeutic candidates for aimed to overcoming of metabolic syndrome from complementary and alternative medicinal natural resources worldwide, we have examined the bioassay-guided separation and structure determination of the active constituents among them and the synthetic studies including the corresponding analog synthesis and SAR studies.
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Academic Significance and Societal Importance of the Research Achievements |
補完医療や代替医療に用いられる天然資源のなかで,疾病の予防や初期症状の緩和などの生体調節機能を有する食用資源について,その機能の科学的評価と機能を発現する分子の特定を行ない,科学的評価に基づく機能性食品素材の開発を志向した食品薬学研究を行う.加えて,見いだした機能性成分を鋳型とした高活性アナログの網羅的合成および生物活性評価による医薬候補物質の創製を併せて実施する.本研究成果によって,新たな機能性食品素材が見いだされ,また,その機能性成分をシーズとした新たな医薬候補物質の提案に繋がることが期待される.
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Report
(4 results)
Research Products
(133 results)
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[Journal Article] Major constituents of Cistanche tubulosa , echinacoside and acteoside, inhibit sodium-dependent glucose cotransporter 1-mediated glucose uptake by intestinal epithelial cells2017
Author(s)
Shimada H., Urabe Y., Okamoto Y., Li Z., Kawase A., Morikawa T., Tu P., Muraoka O., Iwaki M.
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Journal Title
Jouranl of Functional Foods
Volume: 39
Pages: 91-95
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Identification of ACA-28, a 1'-acetoxychavicol acetate analogue compound, as a novel modulator of ERK MAPK signaling, which preferentially kills human melanoma cells.2017
Author(s)
Satoh R, Hagihara K, Matsuura K, Manse Y, Kita A, Kunoh T, Masuko T, Moriyama M, Moriyama H, Tanabe G, Muraoka O, Sugiura R.
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Journal Title
Genes Cells
Volume: 印刷中
Issue: 7
Pages: 608-618
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Total synthesis, structural elucidation and anti-inflammatory activity evaluation of 2-deoxy-3,6-anhydro hexofuranoside derivatives isolated from Sauropus rostratus2016
Author(s)
Zhang C., Wang C., Wang Z., Tanabe G., Muraoka O., Lin A., Xu J., Wu X., Wu L., Xie W.
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Journal Title
Organic & Biomolecular Chemistry
Volume: 14
Issue: 46
Pages: 10906-10913
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Aromatase Inhibitory Activity of Geranylated Coumarins, Mammeasins C and D, Isolated from the Flowers of <i>Mammea siamensis</i>2016
Author(s)
Ninomiya K., Shibatani K., Sueyoshi M., Chaipech S., Pongpiriyadacha Y., Hayakawa T., Muraoka O., Morikawa T.
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Journal Title
Chemical and Pharmaceutical Bulletin
Volume: 64
Issue: 7
Pages: 880-885
DOI
NAID
ISSN
0009-2363, 1347-5223
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines2016
Author(s)
Ninomiya K., Motai C., Nishida E., Kitagawa N., Yoshihara K., Hayakawa T., Muraoka O., Li X., Nakamura S., Yoshikawa M., Matsuda H., Morikawa T.
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Journal Title
Journal of Natural Medicines
Volume: 70
Issue: 3
Pages: 435-451
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Hydrophobic substituents increase the potency of salacinol, a potent a-glucosidase inhibitor from Ayurvedic traditional medicine ‘Salacia’2016
Author(s)
Tanabe G., Xie W., Balakishan G., Amer MFA., Tsutsui N., Takemura H., Nakamura S., Akaki J., Ninomiya K., Morikawa T., Nakanishi I., Muraoka O.
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Journal Title
Bioorganic and Medicinal Chemistry
Volume: 24
Issue: 16
Pages: 3705-3715
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Mangiferin, a novel nuclear factor kappa B-inducing kinase inhibitor, suppresses metastasis and tumor growth in a mouse metastatic melanoma model.2016
Author(s)
Takeda T, Tsubaki M, Sakamoto K, Ichimura E, Enomoto A, Suzuki Y, Itoh T, Imano M, Tanabe G, Muraoka O, Matsuda H, Satou T, Nishida S.
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Journal Title
Toxicol Appl Pharmacol.
Volume: 306
Pages: 105-112
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Mangiferin induces apoptosis in multiple myeloma cell lines by suppressing the activation of nuclear factor kappa B-inducing kinase.2016
Author(s)
Takeda T, Tsubaki M, Kino T, Yamagishi M, Iida M, Itoh T, Imano M, Tanabe G, Muraoka O, Satou T, Nishida S.
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Journal Title
Chem Biol Interact.
Volume: 251
Pages: 26-33
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Mangiferin enhances the sensitivity of human multiple myeloma cells to anticancer drugs through suppression of the nuclear factor κB pathway2016
Author(s)
Takeda T, Tsubaki M, Kino T, Kawamura A, Isoyama S, Itoh T, Imano M, Tanabe G, Muraoka O, Satou T, Nishida S
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Journal Title
Int J Oncol
Volume: 48
Issue: 6
Pages: 303-309
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Highly Diastereoselective Route to α-Glucosidase Inhibitors, Neosalacinol and Neoponkoranol2016
Author(s)
Tanabe G., Matsuda Y., Oka M., Kunikata Y., Tsutsui N., Xie W., Balakishan G., Amer MFA., Marumoto S., Muraoka O.
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Journal Title
The Journal of Organic Chemistry
Volume: 81
Issue: 8
Pages: 3407-3415
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Design, synthesis and biological evaluation of 30-benzylated analogs of 30-epi-neoponkoranol as potent a-glucosidase inhibitors2016
Author(s)
Liu D., He W., Wang Z., Liu L., Wang C., Zhang C., Wang C., Wang Y., Tanabe G., Muraoka O., Wu X., Wu L., Xie W.
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Journal Title
European Journal of Medicinal Chemistry
Volume: 110
Pages: 224-236
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Anti-obese effect of trans-tiliroside2018
Author(s)
Ninomiya Kiyofumi, Kitahara Megumi, Hori Yuichiro, Sakai Chie, Nagatomo Akifumi, Yoshikawa Masayuki, Muraoka Osamu, Morikawa Toshio
Organizer
29th International Conference on Polyphenols / 9 th Tannin Conference (ICP+TC 2018, Madison, USA)
Related Report
Int'l Joint Research
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[Presentation] Highly diastereoselective synthesis of salacinol-type α-glucosidase inhibitors and evaluation of their in vivo α- glucosidase inhibitory activity2018
Author(s)
Ishikawa Fumihiro, Jinno Kazumi, Sonoda Naoki, Kinouchi Eri, Akaki Junji, Ninomiya Kiyofumi, Marumoto Shinsuke, Muraoka Osamu, Morikawa Toshio, Tanabe Genzoh
Organizer
28th International Symposium on the Organic Chemistry of Sulfur (ISOCS-28, Tokyo, Japan)
Related Report
Int'l Joint Research
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[Presentation] Limonoids from Brazilian folk medicine, Andiroba, with fat metabolizing activity in hepatocytes2016
Author(s)
Kiyofumi Ninomiya, Kumi Ninomiya, Chie Sakai, Osamu Muraoka, Takashi Kikuchi, Takeshi Yamada, Reiko Tanaka, Toshio Morikawa
Organizer
The 12th International Conference on Protein Phosphatase (ICPP12)
Place of Presentation
Kindai University, Osaka
Year and Date
2016-10-27
Related Report
Int'l Joint Research
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[Presentation] Quantitative determination of alkaloids in lotus flower (the flower buds of Nelumbo nucifera) and their melanogenesis inhibitory activity2016
Author(s)
Toshio Morikawa, Shuhei Okugawa, Niichiro Kitagawa, Kiyofumi Ninomiya, Chiaki Motai, Iyori Kamei, Masayuki Yoshikawa, Genzoh Tanabe, I-Jung Lee, Osamu Muraoka.
Organizer
International Symposium on Natural Products for the Future 2016 (ISNPF2016)
Place of Presentation
Tokushima Bunri University, Tokushima
Year and Date
2016-09-01
Related Report
Int'l Joint Research
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[Presentation] Growth inhibitory effects of coumarins from the flowers of Mammea siamensis on human digestive tract carcinoma cell lines2016
Author(s)
Kiyofumi Ninomiya, Kenichi Muraki, Mayumi Sueyoshi, Shunsuke Saeki, Chiaki Motai, Saowanee Chaipech, Yutana Pongpiriyadacha, Takao Hayakawa, Osamu Muraoka, Toshio Morikawa
Organizer
International Symposium on Natural Products for the Future 2016 (ISNPF2016)
Place of Presentation
Tokushima Bunri University, Tokushima
Year and Date
2016-09-01
Related Report
Int'l Joint Research
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