Discovery of natural anticancer agents that inhibit cancer cells' tolerance to nutrition starvation and elucidation of their molecular mechanisms

• Project/Area Number: 16K08319
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Drug development chemistry
• Research Institution: University of Toyama
• Principal Investigator: Awale Suresh 富山大学, 学術研究部薬学・和漢系, 准教授 (00377243)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: Pancreatic cancer / Drug discovery / PANC-1 / Antiausterity agent / metabolomics / molecular mechanism / natural products / pancreatic cancer / antiausterity strategy / drug discovery / NMR / biomarker / Antiausterity strategy / Drug Discovery / Natural products / Metabolomics / Biomarker / metbolomics / anti-austerity

Outline of Final Research Achievements

The project aimed to discover novel anti-cancer agents by employing an anti-austerity strategy and to elucidate the mechanism of action through protein and metabolome analysis. Extensive investigation on the anti-cancer activity of the active principals from the medicinal plants Ferula hezarlalehzarica, Ancistrocladus abbreviatus, Calotropis gigantea, Artemisia vulgaris, Anneslea fragrans, Ancistrocladus ealaensis, Bosenbergia pandurata、Uvaria dac, Chamaecyparis obtusa, Citrus hystrix, Derris scandens, Callistemon citrinus has been investigated. The investigation of the mechanism of action of the selected novel anticancer agents was accomplished. In particular, the novel compound, a 5,8-linked naphthyl isoquinoline alkaloid Ancistrolikokine E3 was discovered as a promising anticancer agent that eliminates cancer cells' tolerance to nutrient starvation. Ancistrolikokine E3 was found to inhibit Akt/mTOR/Autophagy Signaling Pathway and causes pancreatic cancer cell death.

Academic Significance and Societal Importance of the Research Achievements

本プ ロジェクトでは、査読付きの国際学術誌に27本の論文を発表し、国際招待講演4件、国際会議8件を含む46件の学会発表を行った。新規化合物Ancistrolikokine E3 は、栄養飢餓に対するがん細胞の耐性を除去する有望な抗がん剤であることが発見され た。この発見は、ACS(米国化学協会) により重要な発見として選ばれ、世界中の数千のニュースメディアにプレスリリースされた。約130の国際的なニュースメディアがこの発見を取り上げた。このプロジェクトで発見された化合物は、抗がん剤開発の潜在的な種を表しています。

Research Products

• [Journal Article] Antiausterity Activity of Secondary Metabolites from the Roots of Ferula hezarlalehzarica against the PANC-1 Human Pancreatic Cancer Cell Line (2020)
  • Author(s): Alilou M., Dibwe D.F., Schwaiger S., Khodami M., Troppmair J. Awale S., Stuppner H.
  • Journal Title: Journal of Natural Products Volume: 83 Issue: 4 Pages: 1099-1106
  • DOI: 10.1021/acs.jnatprod.9b01109
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ancistrosecolines A-F, Unprecedented seco-Naphthylisoquinoline Alkaloids from the Roots of Ancistrocladus abbreviatus, with Apoptosis-Inducing Potential against HeLa Cancer Cells (2020)
  • Author(s): Shaimaa Fayez S., Bruhn T., Feineis D., Assi L.A., Awale S. Bringmann G.
  • Journal Title: Journal of Natural Products Volume: 83 Issue: 4 Pages: 1139-1151
  • DOI: 10.1021/acs.jnatprod.9b01168
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Calosides A-F, Cardenolides from Calotropis gigantea and Their Cytotoxic Activity (2020)
  • Author(s): Nguyen M.T.T., Khang D.H., Nguyen, Dang P.H., Nguyen H.X., Awale S., Nguyen N.T.
  • Journal Title: Journal of Natural Products Volume: 83 Issue: 2 Pages: 385-391
  • DOI: 10.1021/acs.jnatprod.9b00875
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Synthesis of guggulsterone derivatives as potential anti-austerity agents against PANC-1 human pancreatic cancer cells (2020)
  • Author(s): Kohyama A., Yokoyama R., Dibwe D.F., El-Mekkawy S., Meselhy M.R., Awale S., Matsuya Y.
  • Journal Title: Bioorganic & Medicinal Chemistry Letters Volume: 30 Issue: 7 Pages: 126964-126964
  • DOI: 10.1016/j.bmcl.2020.126964
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Sidechain diversification of grandifloracin allows identification of analogues with enhanced anti-austerity activity against human PANC-1 pancreatic cancer cells (2020)
  • Author(s): Alexander B.E., Sun S., Palframan M.J., Kociok-Kohhn G., Dibwe D.F., Watanabe S., Caggiano L., Awale S., Lewis S.E.
  • Journal Title: ChemMedChem Volume: 15 Issue: 1 Pages: 125-135
  • DOI: 10.1002/cmdc.201900549
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Chemical constituents from Artemisia vulgaris and their antiausterity activities against the PANC-1 human pancreatic cancer cell line (2019)
  • Author(s): Omar A.M., Dibwe D.F., Tawila A.M., Sun S., Kim M.J., Phrutivorapongkul A., Awale S.
  • Journal Title: Natural Product Research Volume: 7 Issue: 22 Pages: 1-7
  • DOI: 10.1080/14786419.2019.1700246
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Chemical Constituents of Anneslea fragrans and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line (2019)
  • Author(s): Omar A.M., Dibwe D.F, Tawila A.M., Sun S., Phrutivorapongkul A., Awale S.
  • Journal Title: Journal of Natural Products Volume: 82 Issue: 11 Pages: 3133-3139
  • DOI: 10.1021/acs.jnatprod.9b00735
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ealamines A-H, a Series of Naphthylisoquinolines with the Rare 7,8′-Coupling Site, from the Congolese Liana Ancistrocladus ealaensis, Targeting Pancreatic Cancer Cells (2019)
  • Author(s): Tshitenge D.T., Bruhn T., Feineis D., Schmidt D., Mudogo V., Kaiser M., Brun R., Wurthner F., Awale S., Bringmann G.
  • Journal Title: Journal of Natural Products Volume: 82 Issue: 11 Pages: 3150-3164
  • DOI: 10.1021/acs.jnatprod.9b00755
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Design and synthesis of functionalized coumarins as potential anti-austerity agents that eliminates cancer cells' tolerance to nutrition starvation (2019)
  • Author(s): Awale S., Okada T., Dibwe D.F., Maruyama T., Takahara S., Okada T., Endo S., Toyooka N.
  • Journal Title: Bioorganic & Medicinal Chemistry Letters Volume: 29 Issue: 14 Pages: 1779-1784
  • DOI: 10.1016/j.bmcl.2019.05.010
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ancistrolikokine E3, a 5,8-Coupled Naphthylisoquinoline Alkaloid, Eliminates the Tolerance of Cancer Cells to Nutrition Starvation by Inhibition of the Akt/mTOR/Autophagy Signaling Pathway. (2018)
  • Author(s): Awale S., Dibwe D. F., Balachandran C., Fayez S. Li J., Feineis D., Lombe B.K. Bringmann G.
  • Journal Title: Journal of Natural Products Volume: 81 Issue: 10 Pages: 2282-2291
  • DOI: 10.1021/acs.jnatprod.8b00733
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Chemical constituents of Thai Citrus hystrix and their antiausterity activity against the PANC-1 human pancreatic cancer cell line. (2018)
  • Author(s): Sun S., Phrutivorapongkul A., Dibwe D. F., Balachandran C., Awale S.
  • Journal Title: Journal of Natural Products Volume: 81 Issue: 8 Pages: 1877-1883
  • DOI: 10.1021/acs.jnatprod.8b00405
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ancistrobrevines E-J and related naphthylisoquinoline alkaloids from the West African liana Ancistrocladus abbreviatus with inhibitory activities against Plasmodium falciparum and PANC-1 human pancreatic cancer cells (2018)
  • Author(s): Fayez S. Li J., Feineis D., Assi L.K., Kaiser M., Brun R., Awale S., Bringmann G.
  • Journal Title: Fitoterapia Volume: 131 Pages: 245-259
  • DOI: 10.1016/j.fitote.2018.11.006
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ancistroyafungines A-D, 5,8′- and 5,1′-coupled naphthylisoquinoline alkaloids from a Congolese Ancistrocladus species, with antiausterity activities against human PANC-1 pancreatic cancer cells (2018)
  • Author(s): Muyisa S., Lombe B.K., Feineis D., Dibwe D.F., Maharaj V., Awale S., Bringmann G.
  • Journal Title: Fitoterapia Volume: 130 Pages: 6-16
  • DOI: 10.1016/j.fitote.2018.07.017
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A New Compound from the Rhizomes of Boesenbergia pandurata (2018)
  • Author(s): Do T.N.V., Nguyen H.X., Le T.H., Ngo T.M.T., Dang P.H., Phung N.H., Vo N.T., Nguyen D.M., Le N.H.T., Le T.T., Nguyen M.T.T, Awale S., Nguyen N.T.
  • Journal Title: Nat. Prod. Commun Volume: 13 Pages: 739-740
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Michellamines A6 and A7, and further mono- and dimeric naphthylisoquinoline alkaloids from a Congolese Ancistrocladus liana and their antiausterity activities against pancreatic cancer cells (2018)
  • Author(s): Lombe B.K., Feineis D., Mudogo V., Brun R., Awale S, Bringmann G.
  • Journal Title: RSC Advances Volume: 8 Issue: 10 Pages: 5243-525
  • DOI: 10.1039/c8ra00363g
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A New Alkenylphenol from The Propolis of Stingless Bee Trigona minor (2018)
  • Author(s): Nguyen H.X. , Do T.N.V., Nguyen N.T.T., Dang P.H., Tho L.H., Awale S., Nguyen N.T.T.
  • Journal Title: Natural Products Communication Volume: 13 Pages: 69-70
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ancistrolikokines E-H and Related 5,8'-coupled Naphthylisoquinoline alkaloids from the Congolese Liana Ancistrocladus likoko with Antiausterity Activities against PANC-1 Human Pancreatic Cancer Cells (2017)
  • Author(s): Fayez S. Li J., Feineis D., Mudogo V., Awale S., Bringmann G.
  • Journal Title: RSC Advances Volume: 7 Issue: 85 Pages: 53740-53751
  • DOI: 10.1039/c7ra11200a
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Jozilebomines A and B, Naphthylisoquinoline Dimers from the Congolese Liana Ancistrocladus ileboensis, with Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Cell Line (2017)
  • Author(s): Li J., Seupel R., Bruhn T., Feineis D., Kaiser M., Brun R., Mudogo V., Awale S., Bringmann G.
  • Journal Title: J. Nat. Prod. Volume: 80 Issue: 10 Pages: 2087-2817
  • DOI: 10.1021/acs.jnatprod.7b00650
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Discovery of potential antiausterity agents from the Japanese Cypress Chamaecyparis obtusa (2017)
  • Author(s): Dibwe D.F., Sun S., Ueda J., Balachandran C., Matsumoto K., Awale S.
  • Journal Title: Bioorg. Med. Chem. Lett. Volume: 27 Issue: 21 Pages: 4898-4903
  • DOI: 10.1016/j.bmcl.2017.09.034
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Chemical Constituents of Propolis from Vietnamese Trigona minor and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line (2017)
  • Author(s): Nguyen H.X., Nguyen M.T.T., Nguyen N.T., Awale S.
  • Journal Title: . Nat. Prod. Volume: 80 Issue: 8 Pages: 2345-2352
  • DOI: 10.1021/acs.jnatprod.7b00375
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Gardenifolins A-H, Scalemic Neolignans from Gardenia ternifolia: Chiral Resolution, Configurational Assignment, and Cytotoxic Activities against the HeLa Cancer Cell Line (2017)
  • Author(s): Tshitenge D.T.,Feineis D., Awale S., Bringmann G.
  • Journal Title: J. Nat. Prod. Volume: 80 Issue: 5 Pages: 1604-1614
  • DOI: 10.1021/acs.jnatprod.7b00180
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Lignans from the root of Wikstroemia indica and their cytotoxic activity against PANC-1 human pancreatic cancer cells (2017)
  • Author(s): Chang H., Wang Y., Gao X., Song Z., Awale S., Han N., Liu Z., Yin J.
  • Journal Title: Fitoterapia Volume: 121 Pages: 31-37
  • DOI: 10.1016/j.fitote.2017.06.012
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Phytochemical and cytotoxic studies on the leaves of Calotropis gigantea (2017)
  • Author(s): Nguyen K.D.H., Dang P.H., Nguyen H.X., Nguyen M.T.T., Awale S., Nguyen N.T.
  • Journal Title: Bioorg. Med. Chem. Lett. Volume: 27 Issue: 13 Pages: 2902-2906
  • DOI: 10.1016/j.bmcl.2017.04.087
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Highly oxygenated antiausterity agents from the leaves of Uvaria dac. (2017)
  • Author(s): Awale S, Tawila AM, Dibwe DF, Ueda JY, Sun S, Athikomkulchai S, Balachandran C, Saiki I, Matsumoto K, Esumi H.
  • Journal Title: Bioorg Med Chem Lett. Volume: 27 Issue: 9 Pages: 1967-1967
  • DOI: 10.1016/j.bmcl.2017.03.021
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] α-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana (2017)
  • Author(s): Dang P.H., Nguyen H.X., Duong T.T.T, Tran T.K.T., Nguyen P.T., Vu T.K.T, Vuong H.C, Phan T.H.N, Nguyen M.T.T, Nguyen N.T, Awale S.
  • Journal Title: J. Nat. Prod. Volume: 80 Issue: 4 Pages: 1087-1095
  • DOI: 10.1021/acs.jnatprod.7b00006
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Constituents of the Rhizomes of Boesenbergia pandurata and Their Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Line (2017)
  • Author(s): Nhan Trung Nguyen, Mai Thanh Thi Nguyen, Hai Xuan Nguyen, Phu Hoang Dang, Dya Fita Dibwe, Hiroyasu Esumi, Suresh Awale
  • Journal Title: Journal of Natural Products Volume: 80 Issue: 8 Pages: 141-148
  • DOI: 10.1021/acs.jnatprod.6b00381
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Chemical Constituents of Mangifera indica and Their Antiausterity Activity against the PANC‐1 Human Pancreatic Cancer Cell Line (2016)
  • Author(s): Hai Xuan Nguyen, Truong Nhat Van Do, Tho Huu Le, Mai Thanh Thi Nguyen, Nhan Trung Nguyen, Hiroyasu Esumi, Suresh Awale
  • Journal Title: Journal of Natural Products Volume: 79 Issue: 1 Pages: 2053-2059
  • DOI: 10.1021/acs.jnatprod.6b00784
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Discovery of potential antiausterity agents from Thai Kaempferia parviflora (2019)
  • Author(s): Sijia Sun, Dya Fita Dibwe, Ahmed M. Tawila, Ashraf M. Omar, Sirivan Athikomkulchai, Suresh Awale
  • Organizer: 日本生薬学会第66回年会; 2019 Sept 22-23; 東京.
• [Presentation] Antiausterity constituents from Callistemon citrinus (2019)
  • Author(s): Ahmed M. Tawila, Dya Fita DibweAshraf M. Omar, Sijia Sun, Suresh Awale
  • Organizer: 日本生薬学会第66回年会; 2019 Sept 22-23; 東京.
• [Presentation] Chemical Constituents from Anneslea fragransand Their Antiausterity Activity against the PANC-1 Pancreatic Cancer Cell Line (2019)
  • Author(s): Ashraf M. Omar, Dya Fita Dibwe, Ahmed M. Tawila, Sijia Sun, Ampai Phrutivorapongkul, Suresh Awale
  • Organizer: 日本生薬学会第66回年会; 2019 Sept 22-23; 東京.
• [Presentation] Antiausterity activity against pancreatic cancer cells and antiplasmodial properties of naphthylisoquinoline alkaloids and their analogues (2019)
  • Author(s): Vinesh Maharaj, Severin Muyisa Kavatsurwa, William Shamburger, Phanankosi Moyo, Raina Seupel, Lyn-Marie Birkholtz, Gerhard Bringmann, Blaise Kimbadi Lombe, Suresh Awale
  • Organizer: 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA); 2019 Sept1-5; Innsbruck, Austria
  • Int'l Joint Research
• [Presentation] ステロイド系天然物 Guggulsterone の類縁体合成と抗癌性医薬シーズ探索に向けた 薬理活性評価 (2019)
  • Author(s): 高山亜紀、横山玲、志内玲彩、周越、櫻井宏明 、Suresh Awale、Meselhy R. M. Zayed、松谷裕二
  • Organizer: 第45回反応と合成の進歩シンポジウム; 2019 Oct 28-29; 倉敷.
• [Presentation] 栄養飢餓耐性解除に基づく新規膵臓がん治療薬の開発研究 (2019)
  • Author(s): 西川裕也、乾貴信、岡田卓哉、Dya F. Dibwe、Suresh Awale、豊岡尚樹
  • Organizer: 2019年度有機合成化学北陸セミナー 金沢.
• [Presentation] Constituents of Callistemon citrinus and Their Antiausterity Activities against Human Pancreatic Cancer Cell Line (2019)
  • Author(s): Ahmed M. Tawila, Ashraf M. Omar, Dia Fita Dibwe, Suresh Awale.
  • Organizer: 日本薬学会第139年会, 2019年3月20日～ 23日
• [Presentation] Chemical Constituents from Anneslea fragrans and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line. (2019)
  • Author(s): Ashraf M. Omar, Dia Fita Dibwe, Ahmed M. Tawila, Ampai Phrutivorapongkul, Suresh Awale
  • Organizer: 日本薬学会第139年会, 2019年3月20日～ 23日
• [Presentation] Discovery of potential antiausterity agents from Thai Piper ribesoides (2019)
  • Author(s): Wasinee Su-Authai, Dya Fita Dibwe, Ashraf M. Omar, Orawan Monthakantirat, Supawadee Daodee, Yaowared Chulikhit, Suresh Awale
  • Organizer: 日本薬学会第139年会, 2019年3月20日～ 23日
• [Presentation] Ancistrolikokine E3, a new naphthylisoquinoline alkaloid with potent activity against pancreatic cancer cells. (2018)
  • Author(s): S. Fayez, D. Feineis, B. K. Lombe, D. F. Dibwe, C. Balachandran, S. Awale, G. Bringmann.
  • Organizer: Chemie-Symposium der Studierenden Mainfrankens 2018 Dec.6; Wuerzburg, Germany.
  • Int'l Joint Research
• [Presentation] Synthesis of novel coumarin derivatives directed toward anti-pancreatic cancer agent based on anti-austerity strategy. (2018)
  • Author(s): Takahiro Okada, Satoyuki Takahara, Takuya Okada, Suresh Awale, Dya Fita Dibwe, Satoshi Endo, Naoki Toyooka.
  • Organizer: 36th Medicinal Chemistry Symposium MCS2018, 2018年9月28日～30日
• [Presentation] Discovery of anti-austerity agents from Derris scandens. (2018)
  • Author(s): Dya Fita Dibwe, Haruka Fujino, Mio Aoike, Nusrin Pongterdsak, Ampai Phrutivorapongkul, Suresh Awale.
  • Organizer: 日本生薬学会第65回年会, 2018年9月17日～18日
• [Presentation] Inspired by Nature: Synthesis of Plumbagin Derivatives as Potential Anti-austerity Agents. (2018)
  • Author(s): Suresh Awale, Dya Fita Dibwe, Naoki Toyooka.
  • Organizer: Toyama Academic Gala, 2018年9月14日
• [Presentation] Discovery of anti-austerity agents from Derris scandens. (2018)
  • Author(s): Dya Fita Dibwe, Ampai Phrutivorapongkul, Suresh Awale
  • Organizer: Toyama Academic Gala, 2018年9月14日
• [Presentation] Chemical Constituents of Thai Citrus hystrix and Their Antiausterity Activity against Human Pancreatic Cancer Cell Lines (2018)
  • Author(s): Sijia Sun, Dya Fita Dibwe, Ampai Phrutivorapongkul, Suresh Awale
  • Organizer: The Third International Symposium on Toyama-Asia-Africa Pharmaceutical Network (3rd TAA-Pharm Symposium); 2018 Sept. 10-12; Toyama.
  • Int'l Joint Research
• [Presentation] Constituents of Anneslea fragrans and Their Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Line. (2018)
  • Author(s): Ashraf M. Omar, Ahmed M. Tawila, Dibwe Dya Fita, Ampai Phrutivorapongkul, Suresh Awale
  • Organizer: The Third International Symposium on Toyama-Asia-Africa Pharmaceutical Network (3rd TAA-Pharm Symposium); 2018 Sept. 10-12; Toyama.
  • Int'l Joint Research
• [Presentation] Constituents of Callistemon citrinus and Their Antiausterity Activities against Human Pancreatic Cancer Cell Lines (2018)
  • Author(s): Ahmed M. Tawila, Ashraf M. Omar, Dibwe Dya Fita, Suresh Awale
  • Organizer: The Third International Symposium on Toyama-Asia-Africa Pharmaceutical Network (3rd TAA-Pharm Symposium); 2018 Sept. 10-12; Toyama.
  • Int'l Joint Research
• [Presentation] Anticancer Drug Discovery: Strategy and Leads from Medicinal Plants (2018)
  • Author(s): Suresh Awale
  • Organizer: Toyama-Basel Joint Symposium 2018; 2018 Aug. 23-24; Toyama.
  • Int'l Joint Research / Invited
• [Presentation] Prenylated isoflavones from Thai Derris scandens and their antiausterity activity. (2018)
  • Author(s): Dya FIta Dibwe, Haruka Fujino, Mio Aoike, Nusrin Pongterdsak, Ampai Phrutivorapongkul, Suresh Awale
  • Organizer: Toyama-Basel Joint Symposium 2018; 2018 Aug. 23-24; Toyama.
  • Int'l Joint Research
• [Presentation] Discovery of potential antiausterity agents from Thai Citrus hystrix (2018)
  • Author(s): Sijia Sun, Dya Fita Dibwe, Ampai Phrutivorapongkul, Suresh Awale
  • Organizer: Toyama-Basel Joint Symposium 2018; 2018 Aug. 23-24; Toyama.
  • Int'l Joint Research
• [Presentation] Chemical Constituents from Anneslea fragrans and their antiausterity activity against the PANC-1 human pancreatic cancer cell line. (2018)
  • Author(s): Ashraf M. Omar, Ahmed M. Tawila, Dya Fita Dibwe, Ampai Phrutivorapongkul, Suresh Awale
  • Organizer: Toyama-Basel Joint Symposium 2018; 2018 Aug. 23-24; Toyama.
  • Int'l Joint Research
• [Presentation] Antiausterity activity of isopanduratin-A and its mechanism of action against PANC-1 human pancreatic cancer cells (2018)
  • Author(s): Chandrasekar Balachandran, Dya Fita Dibwe, Suresh Awale
  • Organizer: 日本薬学会第138年会、2018年03月２５日～2018年03月２８日 (金沢)
• [Presentation] Furanocoumarins from the peels of Citrus hystrix and their antiausterity activity against three human pancreatic cancer cell lines (2018)
  • Author(s): Sijia Sun, Dya Fita Dibwe, Chandrasekar Balachandran, Ampai Phrutivorapongkul, Suresh Awale
  • Organizer: 日本薬学会第138年会、2018年03月２５日～2018年03月２８日 (金沢)
• [Presentation] Discovery of potential antiausterity agents from Thai Derris scandens (2018)
  • Author(s): Dya Fita Dibwe, Nusrin Pongterdsak, Kritsaya Chaithatwatthana, Ampai Phrutivorapongkul, Ahmed M. Tawila, Chandrasekar Balachandran, Suresh Awale
  • Organizer: 日本薬学会第138年会、2018年03月２５日～2018年03月２８日 (金沢)
• [Presentation] ベトナム産スオウCaesalpinia sappan種子の新規cassane型ジテルペン (2017)
  • Author(s): Suresh Awale, Jun-ya Ueda, Dya FIta Dibwe, Hai Xuan Nguyen, Mai Thanh Thi Nguyen
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台
  • Year and Date: 2017-03-26
• [Presentation] Chemical constituents of Citrus hystrix and their antiausterity activity against the PANC-1 human pancreatic cancer cell line (2017)
  • Author(s): Sijia Sun, Ampai Phrutivorapongkul, Dya Fita Dibwe, Suresh Awale
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台
  • Year and Date: 2017-03-26
• [Presentation] Cadinane-type sesquiterpenes from Chamaecyparis obtusa and their antiausterity activity (2017)
  • Author(s): Dya Fita Dibwe, Sijia Sun, Jun-ya Ueda, Matsumoto K., Suresh Awale
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台
  • Year and Date: 2017-03-26
• [Presentation] The story of arctigenin: a leading anti-pancreatic cancer agent from Kampo medicine (2017)
  • Author(s): Suresh Awale
  • Organizer: The 90th Annual meeting of the Japanese Pharmacological Society
  • Place of Presentation: Nagasaki
  • Year and Date: 2017-03-15
  • Invited
• [Presentation] Thai indigenous vegetables and condiments as a potential source of anti-pancreatic cancer agents (2017)
  • Author(s): Ampai Phrutivorapongkul, Dya Fita Dibwe, Sijia Sun, Suresh Awale
  • Organizer: The 2nd International Conference on Herbal and Traditional Medicine
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2017-01-25
  • Int'l Joint Research
• [Presentation] Discovery of natural anti-cancer agents targeting cancer cells' tolerance to nutrition starvation (2017)
  • Author(s): Suresh Awale, Dya Fita Dibwe
  • Organizer: The 19th Takeda Science Foundation Symposium on Bioscience "Chronic Inflammation - Initiation, Progression and Resolution"
  • Place of Presentation: Osaka
  • Year and Date: 2017-01-20
• [Presentation] Brazilian Green Propolis as the Source for anti-pancreatic cancer agents (2017)
  • Author(s): Dya Fita Dibwe, Sijia Sun, Jun-ya Ueda, Suresh Awale
  • Organizer: The 19th Takeda Science Foundation Symposium on Bioscience "Chronic Inflammation - Initiation, Progression and Resolution"
  • Place of Presentation: Osaka
  • Year and Date: 2017-01-20
• [Presentation] Application of NMR metabolomics in understanding the physiological target of Kampo medicine (2017)
  • Author(s): Suresh Awale
  • Organizer: 第７回 和漢研・熱研ジョイントセミナー、2017年12月4日（長崎）
• [Presentation] Bergamottin, an anti-austerity agent from Citrus hystrix induced autophagy mediated PANC-1 cell death (2017)
  • Author(s): Sijia Sun, Dya Fita Dibwe, Chandrasekar Balachandran, Ampai Phrutivorapongkul, Suresh Awale
  • Organizer: International Symposium on Scientific Research of Traditional Medicine、2017年11月10 日 （Toyama）
  • Int'l Joint Research
• [Presentation] Study on the anti-austerity activity of Derris scandens extract against the PANC-1 human pancreatic cancer cell line (2017)
  • Author(s): Nusrin Pongterdsak, Kristaya Chaithatwatthana, Ampai Phrutivorapongkul, Sijia Sun, Ahmed M. Tawila, Ashraf M. Omar, Chandrasekar Balachandran, Dya Fita Dibwe, Suresh Awale.
  • Organizer: International Symposium on Scientific Research of Traditional Medicine、2017年11月10 日 （Toyama）
  • Int'l Joint Research
• [Presentation] Anti-austerity activity of Piper betle extract against the PANC-1 human pancreatic cancer cell line (2017)
  • Author(s): Kristaya Chaithatwatthana, Nusrin Pongterdsak, Ampai Phrutivorapongkul, Sijia Sun, Ashraf M. Omar, Ahmed M. Tawila, Chandrasekar Balachandran, Dya Fita Dibwe, Suresh Awale.
  • Organizer: International Symposium on Scientific Research of Traditional Medicine、2017年11月10 日 （Toyama）
  • Int'l Joint Research
• [Presentation] Synthesis and evaluation of preferential cytotoxicity under nutrient-deprived conditions of plumbagin derivatives (2017)
  • Author(s): Takahiro Maruyama, Takahiro Okada, Takuya Okada, Satoyuki Takahara, Chandrashaker Balachandran, Dya Fita Dibwe, Suresh Awale, Naoki Toyooka
  • Organizer: The 35th Medicinal Chemistry Symposium, 201７年03月２５日 ～201７年03月２7日 （Nagoya）
• [Presentation] Discovery of potential anticancer agents from the Japanese cypress “Hinoki” (2017)
  • Author(s): Suresh Awale
  • Organizer: Toyama Academic GALA 2017, 2017年9月27 日 (Toyama).
• [Presentation] Chemical Constituents of Piper longum and their Antiausterity activity (2017)
  • Author(s): Dya Fita Dibwe, Suresh Awale
  • Organizer: Toyama Academic GALA 2017, 2017年9月27 日 (Toyama).
• [Presentation] Discovery of antiausterity strategy based anticancer agents from Citrus hystrix DC. (2017)
  • Author(s): Sijia Sun, Dya Fita Dibwe, Chandrasekar Balachandran, Ampai Phrutivorapongkul, Suresh Awale
  • Organizer: Toyama Academic GALA 2017, 2017年9月27 日 (Toyama).
• [Presentation] Discovery of natural anti-cancer agents targeting cancer cells’ tolerance to nutrition starvation (2017)
  • Author(s): Suresh Awale
  • Organizer: he 1st International Conference on Natural Medicine (ICNM2017), "From Local Wisdom to International Research", 2017年8月5日 ～2017年8月6日 (Bangkok, Thailand)
  • Int'l Joint Research / Invited
• [Presentation] Recent advances in antiausterity strategy guided anticancer drug discoveries (2016)
  • Author(s): Suresh Awale
  • Organizer: The 5th International Symposium on Bioactivities and Disease Prevention of Phytochemicals and Natural Products for Health
  • Place of Presentation: National Chiayi University, Taiwan
  • Year and Date: 2016-11-25
  • Int'l Joint Research / Invited
• [Presentation] Screening of Thai indigenous vegetables and condiments as a source for anti-pancreatic cancer agents (2016)
  • Author(s): Ampai Phrutivorapongkul, Sijia Sun, Dya Fita Dibwe, Suresh Awale
  • Organizer: 第21回日本フードファクター学会 学術集会
  • Place of Presentation: 富山
  • Year and Date: 2016-11-19
• [Presentation] Tomocins A-D, new cassane diterpenes from the seed kernels of Caesalpinia sappan (2016)
  • Author(s): Suresh Awale, Dya Fita Dibwe, Jun-ya Ueda, Hai Xuan Nguyen, Mai Thanh Thi Nguyen
  • Organizer: 日本生薬学会第63回年会
  • Place of Presentation: 富山
  • Year and Date: 2016-09-24
• [Presentation] Chemical Constituents of Mangifera indica and Their Anti Austerity Activity against the PANC-1 Human Pancreatic Cancer Cell Line (2016)
  • Author(s): Hai Xuan Nguyen, Suresh Awale
  • Organizer: The First International Symposium on Toyama-Asia-Africa Pharmaceutical Network
  • Place of Presentation: Toyama
  • Year and Date: 2016-09-12
  • Int'l Joint Research
• [Presentation] Potential Anticancer Agents from the Wood of Chamaecyparis obtusa (2016)
  • Author(s): Dya Fita Dibwe, Suresh Awale
  • Organizer: The First International Symposium on Toyama-Asia-Africa Pharmaceutical Network,
  • Place of Presentation: Toyama
  • Year and Date: 2016-09-12
  • Int'l Joint Research
• [Presentation] Advances in antiausterity strategy based anticancer drug discoveries (2016)
  • Author(s): Suresh Awale
  • Organizer: he 2016 Joint Symposium of The Natural Products Research Institute at Seoul National University and The Institute of Natural Medicine at University of Toyama
  • Place of Presentation: Toyama