| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Staphylococcal superantigen like is a family of exoproteins, that consist of 14 SSLs and contributes to immune evasion of S. aureus. We attempted to identify their unknown host target molecules, and specify responsible region for the binding to the target molecules. In this study, we have identified the responsible regions for the binding of SSL10 to prothrombin, that of SSL10 binding to IgG, and that of SSL5 interfere for the proteolytic activity of MMP-9. We have revealed that SSL12 activates mast cells. SSL12 induces the degranulation of mast cells and cytokine production. SSL12 increased vascular permeability when it applied intradermally.
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