The role of Staphylococcal superantigen like in the virulence of S. aureus and application for drug discovery
| Project/Area Number |
16K08345
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
Itoh Saotomo 名古屋市立大学, 大学院薬学研究科, 准教授 (70308013)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 細菌毒素 / 黄色ブドウ球菌 / アレルギー / 免疫回避 / マスト細胞 / MMP / 血液凝固 / 感染症 / 免疫学 / 薬学 |
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| Outline of Final Research Achievements |
Staphylococcal superantigen like is a family of exoproteins, that consist of 14 SSLs and contributes to immune evasion of S. aureus. We attempted to identify their unknown host target molecules, and specify responsible region for the binding to the target molecules. In this study, we have identified the responsible regions for the binding of SSL10 to prothrombin, that of SSL10 binding to IgG, and that of SSL5 interfere for the proteolytic activity of MMP-9. We have revealed that SSL12 activates mast cells. SSL12 induces the degranulation of mast cells and cytokine production. SSL12 increased vascular permeability when it applied intradermally.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果は黄色ブドウ球菌の毒素を介したアレルギー疾患の発症メカニズムの解明に寄与すると考えられる．今回同定したSSLの最小機能領域はSSLの機能阻害を作用点とした医薬品開発，SSLの標的分子阻害作用を応用した創薬に寄与すると考えられる．公衆衛生上の脅威である黄色ブドウ球菌の毒素を介した新たな疾患への寄与，毒素を標的とした創薬の可能性を提示することができた．
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] 5-Hydroxy-2-methylpyridine Isolated from Cigarette Smoke Condensate Aggravates Collagen-Induced Arthritis in Mice2018
Author(s)
Masafumi Takeno, Shinya Kitagawa, Junpei Yamanaka, Mayumi Teramoto, Haruka Tomita, Naohiro Shirai, Saotomo Itoh, Shigeaki Hida, Kazuichi Hayakawa, Kikuo Onozaki, Takemasa Takii
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Journal Title
Biological and Pharmaceutical Bulletin
Volume: 41
Issue: 6
Pages: 877-884
DOI
NAID
ISSN
0918-6158, 1347-5215
Year and Date
2018-06-01
Related Report
Peer Reviewed / Open Access
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[Journal Article] 5-hydroxy-2-methylpyridine isolated from cigarette smoke condensate aggravates collagen-induced arthritis in mice2018
Author(s)
Masafumi Takeno, Shinya Kitagawa, Junpei Yamanaka, Mayumi Teramoto, Haruka Tomita, Naohiro Shirai, Saotomo Itoh, Shigeaki Hida, Kazuich Hayakawa, Kikuo Onozaki, Takemasa Takii
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Journal Title
Biological and Pharmaceutical Bulletin
Volume: 印刷中
Related Report
Peer Reviewed
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[Presentation] ANALYSIS OF THE ADAPTATION MECHANISM OF MYCOBACTERIUM AVIUM UNDER THE ACID ENVIRONMENT2019
Author(s)
Shouta Ogawa, Ryoji Yamamoto, Yasuhiro Horita, Saotomo Itoh, Naoya Ohara, Tetsuya Yagi, Kenji Ogawa, Shinji Maeda, Kei Nishimori, Nagatoshi Fujiwara, Yoshitaka Goto, Toshio Yamazaki, Shigeaki Hida, Kikuo Onozaki, Takemasa Takii
Organizer
U.S.-Japan Cooperative Medical Sciences Program (USJCMSP) 21st International Conference on Emerging Infectious Diseases in the Pacific Rim
Related Report
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[Presentation] Contribution of arginine deiminase pathway to the acid tolerance response in Mycobacterium avium substrains avium and hominissuis2018
Author(s)
Yasuhiro Horita, Saotomo Itoh, Naoya Ohara, Tetsuya Yagi, Kenji Ogawa, Shinji Maeda, Kei Nishimori, Nagatoshi Fujiwara, Yasutaka Goto, Toshio Yamazaki, Shigeaki Hida, Kikuo Onozaki, Takemasa Takii
Organizer
ASM microbe 2018
Related Report
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