| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The constitutive active/androstane receptor (CAR) controls genes involved in xenochemical metabolism. Although numerous cofactors have been reported to be involved in CAR-mediated transactivation, unknown and poorly defined proteins recruited by CAR have yet to be characterized. In this study, a novel CAR-interacting proteins, cell cycle and apoptosis regulator 1 (CCAR1) and Tripartite Motif Containing 24（TRIM24）, were identified as novel CAR binding proteins. Furthermore, knock down of these cofactors are showed different effect of CAR-induced transactivation. These findings demonstrated CCAR1 and TRIM24 to be novel transcriptional cofactors for CAR and provided insight regarding the mechanism of CAR-mediated gene-selective transactivation.
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