Activation of cell-mediated immunity by healthy foods and suppliments is examined to develop versatile adjuvant through intestinal immunity.
| Project/Area Number |
16K08361
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Kyushu University of Health and Welfare |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
渡辺 渡 九州保健福祉大学, 保健科学部, 教授 (50399218)
杉田 千泰 九州保健福祉大学, 薬学部, 助教 (70632694)
吉田 裕樹 九州保健福祉大学, 薬学部, 講師 (90469411)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 腸管免疫 / 細胞性免疫 / サプリメント / 健康食品 / 経口アジュバント / ウイルス感染 / Th1サイトカイン |
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| Outline of Final Research Achievements |
Activation of cell-mediated immunity by healthy foods and suppliments was examined to develop versatile adjuvant through intestinal immunity for virus infections. We found that 1)oral administration of Brazilian propolis (AF-08) and Lactobacillus plantarum strain 06CC2 was effective to increase the rate of Lactobacillus in intestine and activated cell-medicated immunity in mice, 2)AF-08 was effective against collagen-induced arthritis in mice and confirmed to possess cytokine-modulatory activity in vivo, 3)oral administration of γ-aminobutyric acid as a majour compound involved in aqueous extract of Moringa oleifera Lam. leaves (AqMol) augmented the a delayed-type hypersensitivity reaction as a major host defense in cutaneously HSV-1-infected mice, and 4) AqMol was suggested to alleviate allergic symptoms through suppression of mast cell activation and/or improving the Th1/Th2 balance to Th1 dominance in allergic mice.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の特色・独創的な点は、ウイルスとは異なる抗原を認識する腸管免疫系を介して、種々のウイルス感染に対する細胞性免疫を賦活化できる汎用性のある経口アジュバントの開発に繋げることである。この考えは、従来の体液性免疫賦活作用の強いワクチンの概念とは異なり、腸管免疫系が微生物に特有かつ共有の構造を認識し、細胞性免疫反応を強く誘導することができることに由来している。この系が立証できれば、ウイルス感染症の予防・治療に偉大な貢献が可能である。
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Report
(4 results)
Research Products
(59 results)
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[Journal Article] Perinatal exposure to tetrabromobisphenol A (TBBPA), a brominated flame retardant, exacerbated the pneumonia in respiratory syncytial virus (RSV)-infected offspring mice2017
Author(s)
3)Watanabe W, Hirose A, Takeshita T, Hashiguchi S, Sakata K, Konno K, Miyauchi A, Akashi T, Yoshida H, Sugita C, Kurokawa M.
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Journal Title
The Journal of Toxicological Sciences
Volume: 42
Issue: 6
Pages: 789-795
DOI
NAID
ISSN
0388-1350, 1880-3989
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] T-705 (Favipiravir) suppresses tumor necrosis factor-α production in response to influenza virus infection: A beneficial feature of T-705 as an anti-influenza drug.2017
Author(s)
Tanaka, T., Kamiyama, T., Daikoku, T., Takahashi, K., Nomura, N., Kurokawa, M., Shiraki, K.
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Journal Title
Acta virologica
Volume: 61
Pages: 48-55
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] チタン酸カリウム曝露のRSV肺炎への影響2017
Author(s)
寺田央子, 加藤雄大, 橋口誠子, 権藤喜貴, 広瀬明彦, 宮内亜宜, 明石敏, 吉田裕樹, 杉田千泰, 黒川昌彦, 渡辺渡
Organizer
日本薬学会第137年会
Place of Presentation
仙台
Year and Date
2017-03-24
Related Report
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[Presentation] 単純ヘルペスウイルス1型感染マウスにおけるプロバイオティクス（モンゴル乳製品由来乳酸菌）による細胞性免疫賦活化作用について2016
Author(s)
松崎竜也, 細川洋一朗, 石橋将高, 梅本啓史, 林里采, 竹田志郎, 竹下正彦, 杉田千泰, 吉田裕樹, 渡辺渡, 黒川昌彦
Organizer
第33回日本薬学会九州支部大会
Place of Presentation
鹿児島
Year and Date
2016-12-03
Related Report
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[Presentation] 単純ヘルペスウイルス1型感染マウスへのプロバイオティクス（モンゴル乳製品由来乳酸菌）の影響2016
Author(s)
松崎竜也, 石橋将高, 梅本啓史, 林里采, 細川洋一朗, 竹田志郎, 杉田千泰, 吉田裕樹, 渡辺渡, 竹下正彦, C.Tsend-Ayush, T.Oyunsuren, 黒川昌彦
Organizer
第26回抗ウイルス療法学会
Place of Presentation
名古屋
Year and Date
2016-05-13
Related Report
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