| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
Our previous studies have shown that oral absorption of food allergens enhanced by non-steroidal anti-inflammatory drugs (NSAIDs) was an exacerbating factor in the development of food allergy. In this study, we tried to examine the effect of aspirin on oral sensitization to an egg-white allergen ovalbumin (OVA) in rats. As results, enhancement of OVA absorption due to impairment of intestinal barrier function by aspirin is considered to be one of the reasons of enhanced oral sensitization with OVA by aspirin. However, enhanced oral sensitization to OVA cannot be ascribed to increased absorption of OVA from the intestinal tract only. We also found that inhibition of cyclooxigenase-1 activity by NSAIDs might involve in the enhancement of sensitization with OVA irrespective of sensitization pathway. These findings shed new light on the pathophysiological mechanisms underlying oral sensitization to food allergens.
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