| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Atopic dermatitis is a disease where there are repeated exacerbation and remission, and skin microbiome can also be changed during exacerbation and remission periods. Fungus Malassezia is one of the exacerbating factors of atopic dermatitis. In this study, we have succeeded in isolating Staphylococcus sp. MPU-7 from patients as a bacterium with the ability to reduce cell cytotoxicity. The microorganism was also able to increase the expression of skin barrier function related proteins and antimicrobial peptides in vitro. There are considerations for strain MPU7-1 to be a candidate for skin microbiome transplantation.
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