| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Under pathological conditions associated with inflammation, the expression of drug-metabolizing enzymes and transporters that regulate drug response is markedly down-regulated. However, details of the mechanism underlying their down-regulation are still unknown. In this study, we have investigated the molecular mechanisms by which pro-inflammatory cytokine IL-6 regulates human CYP1A2 and CAR expression, utilizing in vitro system. Our results show that the IL-6 responsive transcription factor DEC1 could act as a common repressor on their promoters.
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