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Epigenetic regulation of mTOR signalling pathway in placental nutrient transport.

Research Project

Project/Area Number 16K08408
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical pharmacy
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

HIRANO Takeshi  北海道医療大学, 薬学部, 教授 (00322826)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsmTOR / エピジェネティック / 栄養 / 胎盤 / 母体 / 胎児 / トランスポーター / 輸送 / p70 S6 kinase / カルバペネム系抗生物質 / セフェム系抗生物質 / バルプロ酸 / アミノ酸 / 性ホルモン / グルタミントランスポーター / BeWo / 活性化変動 / 輸送能 / ラパマイシン / エベロリムス / 栄養輸送 / 医療薬学 / 食品栄養学 / 医薬品情報学 / 安全性学
Outline of Final Research Achievements

The mammalian target of rapamycin (mTOR) signaling pathways control protein synthesis in response to nutrient availability. Moreover, mTOR is a positive regulator of placental nutrient transport and is involved in the regulation of fetal growth. We focus on the role of mTOR in placental development, nutrient regulation and response.

Academic Significance and Societal Importance of the Research Achievements

精密にプログラムされた一連の遺伝子発現と子宮内で極めて速い速度で発育・発達を続けている胎児の健やかな誕生に多大な貞献をもたらす。妊娠初期における栄養素の欠如は胎児にとって致命的であり、エピジェネティックな変化も含めた研究意義は極めて大きい。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Valproic acid transport in the choriocarcinoma placenta cell line JEG-3 proceeds independently of the proton-dependent transporters MCT1 and MCT42018

    • Author(s)
      Yuri Ishiguro, Ayako Furugen, Katsuya Narumi, Ayako Nishimura, Takeshi Hirano, Masaki Kobayashi, Ken Iseki.
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 印刷中 Issue: 6 Pages: 270-274

    • DOI

      10.1016/j.dmpk.2018.03.004

    • NAID

      210000170209

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 抗生物質のpH変動に基づく配合変化の検討2018

    • Author(s)
      滝川裕基、高村茂生、櫻田 渉、中山 章、吉田栄一、平野 剛
    • Organizer
      第65回北海道薬学大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 簡易型自記式食事歴法質問票(BDHQ)の概略と活用方法2018

    • Author(s)
      工藤雅之、高村茂生、櫻田 渉、中山 章、吉田栄一、平野 剛
    • Organizer
      第65回北海道薬学大会
    • Related Report
      2018 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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