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Analysis of the role of prostaglandin in the refractory peripheral facial paralysis

Research Project

Project/Area Number 16K08413
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical pharmacy
Research InstitutionShowa University

Principal Investigator

Kamei Daisuke  昭和大学, 薬学部, 准教授 (80515651)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords顔面神経麻痺 / プロスタグランジン / 末梢性顔面神経麻痺 / プロスタグランジンF2α / プロスタグランジンF受容体(FP) / プロスタグランジンF2 / 抹消性顔面神経麻痺
Outline of Final Research Achievements

An effective therapy is not established for aggravation of the peripheral facial nerve palsy.
In this study, we examined the in vivo role of prostaglandin in the facial nerve regeneration using a mouse model of facial nerve crush injury. In vivo studies showed that contribution of prostaglandin F2a (PGF2a) was found in the process of regeneration of facial nerve after crush injury. This study suggested that inhibition of PGF2a was useful as a new therapy for peripheral facial nerve palsy.

Academic Significance and Societal Importance of the Research Achievements

末梢性顔面神経麻痺は、脳神経麻痺の中で最も頻度の高い疾患であり、難治症例に対する治療法は確立されていない。本研究では、顔面神経麻痺の回復過程において、生理活性脂質PGF2αが麻痺の治療抵抗因子として寄与していることを明らかにした。本研究成果は、末梢性顔面神経麻痺の難治化に対して、PGF2α阻害に着目した治療戦略が有効である可能性を示唆しており、学術的・社会的にも意義のある新しい知見であった。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2019 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Anti-inflammatory effects of new catechin derivatives in a hapten-induced mouse contact dermatitis model2019

    • Author(s)
      Nakano Eriko、Kamei Daisuke、Murase Remi、Taki Iori、Karasawa Koji、Fukuhara Kiyoshi、Iwai Shinichi
    • Journal Title

      European Journal of Pharmacology

      Volume: 845 Pages: 40-47

    • DOI

      10.1016/j.ejphar.2018.12.036

    • NAID

      130007900581

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] KRAS and EGFR Amplifications Mediate Resistance to Rociletinib and Osimertinib in Acquired Afatinib-Resistant NSCLC Harboring Exon 19 Deletion/T790M in EGFR2018

    • Author(s)
      Nakatani Kaori、Yamaoka Toshimitsu、Ohba Motoi、Fujita Ken-Ichi、Arata Satoru、Kusumoto Sojiro、Taki-Takemoto Iori、Kamei Daisuke、Iwai Shinichi、Tsurutani Junji、Ohmori Tohru
    • Journal Title

      Molecular Cancer Therapeutics

      Volume: 18 Issue: 1 Pages: 112-126

    • DOI

      10.1158/1535-7163.mct-18-0591

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 末梢性顔面神経麻痺の回復過程におけるプロスタグランジン類の解析2018

    • Author(s)
      亀井大輔、中村彩音、喜多村奈央、滝伊織、村上信吾、増田豊、岩井信市
    • Organizer
      日本薬学会 第138年会(金沢)
    • Related Report
      2017 Research-status Report
  • [Presentation] 末梢性顔面神経麻痺の回復過程におけるプロスタグランジン類の関与の解析2017

    • Author(s)
      亀井 大輔, 伊波 樹, 中村 彩音, 滝 伊織, 髙田 昂輔, 村上 信吾, 増田 豊, 岩井 信市
    • Organizer
      日本薬学会 第137年会
    • Place of Presentation
      宮城県 仙台市
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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