| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Outline of Final Research Achievements |
We reconstructed the relational information between anthracycline anticancer drug (AC) and reactive oxygen species (ROS). Experiments were evaluated for DNA damage and cell death in doxorubicin (DOX), epirubicin (EPI), daunorubicin (DNR), idarubicin (IDR), aclarubicin (ACL). AC damaged DNA in the presence of Cu (II), and its intensity was (DOX, EPI) > (THP, IDR) > ACR >> DNR, and no damage was observed in DNR. On the other hand, as a result of detailed examination of cell death of THP, ACR and IDR, it was suggested that ROS was involved in cell death of THP and ACR, but ROS was not involved in IDR. In addition, Cu (I) was involved in ACR cell death, and the importance of Cu was clarified.
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