Analysis of regulating mechanism for development and differentiation of special cardiomyocytes
| Project/Area Number |
16K08443
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Hiroshima University |
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Principal Investigator |
Hiroki Kokubo 広島大学, 医歯薬保健学研究科(医), 講師 (10270480)
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| Co-Investigator(Kenkyū-buntansha) |
吉栖 正生 広島大学, 医歯薬保健学研究科(医), 教授 (20282626)
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| Research Collaborator |
Saga Yumiko
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 心筋 / 刺激伝導系 / 特殊心筋 |
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| Outline of Final Research Achievements |
Understanding of the molecular mechanism of cadiomyocytes differentiation, how the heart progenitor cells differentiate into the working myocardium consisting atria and ventircles, and also into special myocardium constituting sinus venous, including the sinoatrial node controlling heartbeat, has an important key role in the development of the regenerative medicine technology. In this study, we have examined how this progenitor cells are regulated to differentiate into two working and special myocardium, mainly on the role of the BMP signal, in order to elucidate molecular mechanism of the myocardium differentiation by focusing our newly identified heart progenitor cell population to contribute to the left ventricle, the atria, and the sinus venous, and clarified a new mechanism for myocardium differentiation.
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| Academic Significance and Societal Importance of the Research Achievements |
循環器領域は、iPS細胞より誘導分化させた固有心筋の細胞シートを心不全患者に直接移植する治療法が治験に入るなど、再生医療が実用段階に入っている。しかしながら、心筋前駆細胞が如何にして固有並びに特殊心筋へと分化するのか、その分子メカニズムは分かっていない。本研究によって、Bmpの心筋制御の新たな分子機構を明らかにできたことは、大きな学術的意義を持つと考えられる。この知見を基に、iPSやES細胞から固有心筋や特殊心筋を効率的に分化誘導する方法へと結び着くことが期待され、大きな社会的意義を持つと考えている。
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice.2017
Author(s)
Yusuke Nakatsu, Hiroki Kokubo, Batmunkh Bumdelger, Masao Yoshizumi, Takeshi Yamamotoya, Yasuka Matsunaga, Koji Ueda, Yuki Inoue, Masa-Ki Inoue, Midori Fujishiro, Akifumi Kushiyama, Hiraku Ono, Hideyuki Sakoda, and Tomoichiro Asano
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Journal Title
International Journal of Molecular Sciences
Volume: 18(8)
Issue: 8
Pages: 1704-1717
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Sfrp5 identifies murine cardiac progenitors for all myocardial structures except for the right ventricle.2017
Author(s)
Fujii, M., Sakaguchi, A., Kamata, R., Nagao, M., Kikuchi, Y., Evans, S.M., Yoshizumi M., Shimono, A., Saga, Y., and Kokubo, H.
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Journal Title
Nature Communications
Volume: 8
Issue: 1
Pages: 14664-14664
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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