• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Surface- and Non-surfave dividing progenitors utilize different vascular niche during neocortical development

Research Project

Project/Area Number 16K08479
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General anatomy (including histology/embryology)
Research InstitutionKobe Gakuin University (2017-2018)
Doshisha University (2016)

Principal Investigator

Ken-ichi Mizutani  神戸学院大学, 薬学研究科, 特命教授 (40469929)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords神経幹細胞 / 血管発生 / 微小環境 / 神経発生 / 大脳皮質 / 神経前駆細胞 / 大脳皮質の発生 / 血管 / 幹細胞 / 前駆細胞 / 低酸素 / 中間型幹細胞
Outline of Final Research Achievements

Mammalian neocortical development encompasses an entire set of events that leads to the generation of excitatory and inhibitory neurons from neural progenitors in the dorsal and ventral telencephalon. During these processes, the developing neocortex acquires its vasculature by angiogenesis, a process consisting of proliferation of endothelial cells in existing blood vessels or vascular plexuses, and leading to formation of new blood vessels. Recent studies have suggested that neocortical angiogenesis progresses in a spatially and temporally restricted manner to construct a specialized vascular niche that supports ongoing neurogenesis during neocortical development. Here we showed that periventricular blood vessels selectively influence neocortical progenitors behavior and neurogenesis, highlighting how CNS angiogenesis is utilized to construct neocortical cytoarchitecture.

Academic Significance and Societal Importance of the Research Achievements

血管は、組織細部にわたり養分や酸素を運搬する極めて重要な器官の一つであり、木の枝のごとく一定の組織空間に分布する。血管が空間に如何に伸展し、その伸展を止めるのかという、血管発生を調節する分子機構は未だ未解明の問題が数多く残されている。組織内に構築される血管がどのようにつくられ、これが周囲の組織幹細胞と如何に連携しながら組織・臓器を構築するのかという問いは、効率的な幹細胞の培養法の確立や幹細胞を用いた再生医療の実現化に重要な知見が見出されることが期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (17 results)

All 2019 2018 2017 2016

All Journal Article (5 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) (of which Int'l Joint Research: 4 results,  Invited: 3 results)

  • [Journal Article] Physiological significance of the multipolar cells generated from neural progenitors for the establishment of neocortical cytoarchitecture.2018

    • Author(s)
      Mizutani K
    • Journal Title

      Genes to Cells

      Volume: 23 Issue: 1 Pages: 6-15

    • DOI

      10.1111/gtc.12546

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Prdm8 target gene Ebf3 regulates multipolar-to-bipolar transition in migrating neocortical cells2018

    • Author(s)
      Iwai Ryota、Tabata Hidenori、Inoue Mayuko、Nomura Kei-ichiro、Okamoto Tadashi、Ichihashi Masamitsu、Nagata Koh-ichi、Mizutani Ken-ichi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 495 Issue: 1 Pages: 388-394

    • DOI

      10.1016/j.bbrc.2017.11.021

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular mechanisms of neuro-vascular wiring enabling stem cell maintenance and differentiation2017

    • Author(s)
      水谷健一
    • Journal Title

      生化学

      Volume: 89 Issue: 3 Pages: 384-390

    • DOI

      10.14952/SEIKAGAKU.2017.890384

    • ISSN
      0037-1017
    • Year and Date
      2017-06-25
    • Related Report
      2017 Research-status Report
    • Open Access
  • [Journal Article] Prdm16 is crucial for progression of the multipolar phase during neural differentiation of the developing neocortex.2017

    • Author(s)
      Inoue M, Iwai R, Tabata H, Konno D, Komabayashi-Suzuki M, Watanabe C, Iwanari H, Mochizuki Y, Hamakubo T, Matsuzaki F, Nagata K-I, Mizutani K-I
    • Journal Title

      Development

      Volume: 144 Issue: 3 Pages: 385-399

    • DOI

      10.1242/dev.136382

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fluorescence and Bioluminescence Imaging of Angiogenesis in Flk1-Nano-lantern Transgenic Mice.2017

    • Author(s)
      Matsushita J, Inagaki S, Nishie T, Sakasai T, Tanaka J, Watanabe C, Mizutani KI, Miwa Y, Matsumoto K, Takara K, Naito H, Kidoya H, Takakura N, Nagai T, Takahashi S, Ema M.
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 46597-46597

    • DOI

      10.1038/srep46597

    • NAID

      120007129140

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 大脳皮質における神経ー血管の協調的な発生機構2019

    • Author(s)
      水谷健一
    • Organizer
      日本薬学会 第139年会シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 大脳皮質における神経ー血管の協調的な発生機構2019

    • Author(s)
      水谷健一
    • Organizer
      第7回ニューロカンファレンス和歌山
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 神経分化過程の多極性形態期を制御する分子機構の解明2018

    • Author(s)
      水谷健一
    • Organizer
      第41回 日本分子生物学会ワークショップ
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cross-talk between nervous and vascular systems is essential for neocortical development2018

    • Author(s)
      Ken-ichi Mizutani
    • Organizer
      第61回 日本神経化学会(アジア太平洋神経化学会/日本神経化学会ジョイントシンポジウム)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 大脳皮質における規則的な血管網の構築は、神経幹細胞および前駆細胞の分化を調節する2017

    • Author(s)
      水谷 健一
    • Organizer
      日本分子生物学会(生命科学系合同年次大会)
    • Related Report
      2017 Research-status Report
  • [Presentation] Prdm16 is crucial for progression of the multipolar phase during neural differentiation of the developing neocortex.2017

    • Author(s)
      水谷 健一
    • Organizer
      日本神経化学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 神経幹細胞の微小環境としての血管の役割2017

    • Author(s)
      水谷 健一
    • Organizer
      日本再生医療学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 発生期大脳皮質における血管発生の規則性は、神経分化を調節する2016

    • Author(s)
      水谷健一
    • Organizer
      第39回日本分子生物学会フォーラム(多様な神経細胞を生み出す複雑・難解な神経分化システムの理解)
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-12-01
    • Related Report
      2016 Research-status Report
  • [Presentation] ミトコンドリアROSの調節因子Prdm16は、発生期大脳皮質における多極性形態期の調節に決定的な役割を果たす2016

    • Author(s)
      岩井亮太、田畑秀典、井上真悠子、鈴木真理子、永田浩一、水谷健一
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-12-01
    • Related Report
      2016 Research-status Report
  • [Presentation] 発生期大脳皮質における血管発生の規則性とその生理機能の役割2016

    • Author(s)
      渡部千里、岩井亮太、鈴木真理子、山西恵美子、田畑秀典、永田浩一、原田浩、依馬正次、水谷健一
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2016-12-01
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Interdependency between neurogenesis and angiogenesis during neocortical development2016

    • Author(s)
      Ken-ichi Mizutani
    • Organizer
      日本生化学会シンポジウム
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Role of Vascular development during neural differentiation of the developing neocortex2016

    • Author(s)
      水谷健一
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2016-04-21   Modified: 2022-03-04  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi