| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Pancreatic b cells within islets synchronize functionally by cell to cell communication, therefore, necessary and enough insulin secretory response is observed. However, the regulatory mechanism has not been unclear. We investigated the involvement of primary cilia on synchronized secretory function of b cells within islets. Glucose-stimulated insulin secretion (GSIS) from pseudoislets of b cells was increased more than that from b cells in monolayer. Inhibitory effect of somatostatin on GSIS was augmented in pseudoislets compared with b cells in monolayer. Defect of primary cilia resulted in a decrease in inhibitory effect of somatostatin on GSIS in pseudoislets. These results indicate that primary cilia is involved in synchronized secretory function of b cells within islets.
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