| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Neurons in nucleus laminaris (NL) of birds are the coincidence detector of binaural inputs and involved in processing of interaural time difference (ITD) for sound localization. NL neurons with low tuning frequency (low-CF neurons) have prominently long dendrites. However, contributions of dendrites to the ITD processing are still enigma. Previously, we found that synaptic inputs were clustered at distal dendrites of low-CF neurons. In this study, we found that voltage responses generated at distal dendrites were strongly attenuated particularly at the strong inputs. Model study revealed that the clustered inputs at distal dendrite generated large depolarization, which decreased synaptic current and increased K+ channel conductance, then increased the extent of attenuation in an intensity-dependent manner. We concluded that the synaptic clustering at distal dendrite would regulate the size of synaptic potential and maintain the ITD processing according to the input intensity.
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