| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The brain is highly vulnerable to O2 deprivation. It is understood that specialized O2-sensing elements have evolved to monitor and ensure adequate oxygenation of the arterial blood supplying the central nervous system (CNS) with O2. However, peripheral chemoreceptors are unable to directly monitor local pO2 changes, which results from variable levels of neuronal activity or blood perfusion within CNS. Here, we have found that oxygen-sensitive TRPA1 channels is activated by hypoxia in astrocytes. This induces Ca2+ influx that triggers release of ATP from astrocytes to potentiate the activity of the respiratory center. These results suggest that astrocytic TRPA1 plays a specific role in hypoxia adaption of respiratory depth.
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