| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
Abundant glycoproteins exist in bone resorption lacunae, whereas their physiological roles remain unknown. During endochondral ossification, localization of matrix metalloproteinase-9 (MMP-9) was significantly different according to its glycosylation state. Non-glycosylated MMP-9 is exclusively present around tips of capillary vessels in the chondro-osseous junction. On the other hand, sialylated MMP-9 exists in osteoclasts and resorption lacunae accompanied with mature osteoblasts. These results suggest that non-glycosylated MMP-9 attracts endothelial cells, while sialylated MMP-9 enhances the osteoblast migration and bone formation at bone resorption lacunae.
|
