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Elucidation of molecular mechanism for the circadian clock formation during vertebrate development

Research Project

Project/Area Number 16K08521
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionKomatsu University (2018)
Tokyo Medical and Dental University (2016-2017)

Principal Investigator

Hirayama Jun  公立小松大学, 保健医療学部, 教授 (90510363)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords体内時計 / 細胞時計 / 光 / ゼブラフィッシュ / 転写 / 翻訳 / 発生 / 恒常性維持 / 時計蛋白質 / 概日リズム / 生体リズム
Outline of Final Research Achievements

Circadian clocks regulate various physiological processes with a periodicity of approximately 24 h. The exact timing of this rhythm is established by cell-autonomous oscillators called cellular clock. In vertebrates, cellular clocks in early embryos are gradually set in motion during development. In mammals, it is quite difficult to analyze the processes of cellular clock formation during development because embryogenesis proceeds inside the maternal uterus. Thus, the molecular mechanisms underlying the establishment of cellular clocks during vertebrate development are not well understood. Zebrafish eggs are externally fertilized and are transparent. In addition, embryos rapidly develop from fertilized eggs to larvae that swim, making them an excellent model for studies on the ontology of vertebrate clocks. This study used zebrafish to identify noble light-inducible clock proteins as the factor responsible for the light-dependent synchronization of cellular clocks during development.

Academic Significance and Societal Importance of the Research Achievements

ヒトならびにマウスなどのモデル生物を用いた解析から、発生期の体内時計の形成不全が乳幼児の発達障害に関連することが報告されている。従って、生物の発生期の体内時計の形成機構の解明を目指す本研究の成果には、小児発達障害の予防や治療ならびに周産期医療の観点から有益な知見を提唱することが期待される。
体内時計は、生物の恒常性維持を担う重要な機構であり、その異常は睡眠障害や代謝異常といった様々な疾患につながる。従って、この機構がどのように形成されるかを解明することは、体内時計の異常と関連する様々な疾患の予防ならびに治療戦略を構築する際に重要になると考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (12 results)

All 2019 2018 2017 2016 Other

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 5 results) Presentation (5 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results) Remarks (1 results)

  • [Journal Article] The clock components Period2, Cryptochrome1a, and Cryptochrome2a function in establishing light-dependent behavioral rhythms and/or total activity levels in zebrafish2019

    • Author(s)
      Hirayama J, Alifu Y, Hamabe R, Yamaguchi S, Tomita J, Maruyama Y, Asaoka Y , Nakahama K, Tamaru T, Takamatsu K, Takamatsu N, Hattori A, Nishina S, Azuma N, Kawahara A, Kume K, Nishina H.
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 196-196

    • DOI

      10.1038/s41598-018-37879-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A molecular link between the circadian clock, DNA damage responses and oncogene activation2019

    • Author(s)
      Izawa J, and Hirayama J*
    • Journal Title

      Oncogene (Edited by Pinar Erkekolu) InTechOpen

      Volume: Intechopen2018 Pages: 1-15

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The zebrafish as an attractive model animal for the study of the circadian clocks.2018

    • Author(s)
      Hirayama J*
    • Journal Title

      Circadian clock: Regulations, Genetic and External Factors (Edited by Nathaniel Hayes)

      Volume: 0 Pages: 103-127

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel YAP1 Activator, Identified by Transcription-Based Functional Screen, Limits Multiple Myeloma Growth2017

    • Author(s)
      Maruyama Junichi、Inami Kazutoshi、Michishita Fumiyoshi、Jiang Xinliang、Iwasa Hiroaki、Nakagawa Kentaro、Ishigami-Yuasa Mari、Kagechika Hiroyuki、Miyamura Norio、Hirayama Jun、Nishina Hiroshi、Nogawa Daichi、Yamamoto Kouhei、Hata Yutaka
    • Journal Title

      Molecular Cancer Research

      Volume: 16 Issue: 2 Pages: 197-211

    • DOI

      10.1158/1541-7786.mcr-17-0382

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK72017

    • Author(s)
      Yamasaki T, Deki-Arima N, Kaneko A, Miyamura N, Iwatsuki M, Matsuoka M, Fujimori-Tonou N, Okamoto-Uchida Y, Hirayama J, Marth JD, Yamanashi Y, Kawasaki H, Yamanaka K, Penninger JM, Shibata S, Nishina H.
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 7348-7348

    • DOI

      10.1038/s41598-017-07845-x

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Manganese and cobalt activate zebrafish ovarian cancer G-protein-coupled receptor 1 but not GPR42017

    • Author(s)
      J. Negishi, Y. Omori, M. Shindo, H. Takanashi, S. Musha, S. Nagayama, J. Hirayama, H. Nishina, T. Nakakura, C. Mogi, K. Sato, F. Okajima, Y. Mochimaru, H. Tomura
    • Journal Title

      J. Recept. Signal Transduct. Res.

      Volume: 37 Issue: 4 Pages: 401

    • DOI

      10.1080/10799893.2017.1298130

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Circadian rhythm establishment and sleep control by the light-induced clock factors2018

    • Author(s)
      Hirayama J
    • Organizer
      The 41st Annual Meeting of the Japan Neuroscience Society (Kobe, Japan)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ゼブラフィッシュ体内時計の光制御機構2018

    • Author(s)
      平山 順
    • Organizer
      ウロコの会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Molecular mechanism of light-dependent establishment of circadian rhythm2017

    • Author(s)
      Hirayama Jun
    • Organizer
      8th Asia and Oceania Conference for Photobiology (Seoul, The Republic of Korea )
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 概日リズムを形成する細胞時計の光同調機構の解明2016

    • Author(s)
      平山順、アリフ イクラム、仁科博史
    • Organizer
      第39回日本分子生物学年会
    • Place of Presentation
      パシフィコ横浜(神奈川県 横浜市)
    • Year and Date
      2016-12-02
    • Related Report
      2016 Research-status Report
  • [Presentation] Mechanism for light-dependent synchronization of cellular clocks in zebrafish2016

    • Author(s)
      平山順、アリフ イクラム、仁科博史
    • Organizer
      第23回日本時間生物学会学術大会
    • Place of Presentation
      名古屋大学 豊田講堂(愛知県 名古屋市)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
  • [Remarks] Researchmap

    • URL

      https://researchmap.jp/khr

    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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