| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Oxytocin neurons localized in the hypothalamus project to diverse brain regions, and are involved in diverse physiological responses such as social behavior, feeding, and stress response. We aimed to visualize and manipulate individual projection pathways of oxytocin neurons that have complex inputs and outputs. The purpose of this study was to elucidate individual functions or the functional relationship between the projections. Our results showed that the oxytocin receptor-expressing neurons in the prefrontal cortex includes projection neurons other than somatostatin-positive interneurons. In addition, we used retrograde infection of AAV vectors to investigate the projection pattern of oxytocin receptor-expressing neurons in the paraventricular nucleus.
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