Analysis of projecitons from oxytocin neurons and oxytocin receptors
| Project/Area Number |
16K08527
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | オキシトシンニューロン / オキシトシン受容体 / 前頭前皮質 / GFP-dependent Cre / 逆行性感染 / 視床室傍核 / 遺伝子発現制御 / ウイルスベクター / ノックインマウス / オキシトシン / 視床下部室傍核 / ナノボディ / アデノ随伴ウイルスベクター / Cre-DOG / オキシトシン神経 / 投射経路 / DREADD |
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| Outline of Final Research Achievements |
Oxytocin neurons localized in the hypothalamus project to diverse brain regions, and are involved in diverse physiological responses such as social behavior, feeding, and stress response. We aimed to visualize and manipulate individual projection pathways of oxytocin neurons that have complex inputs and outputs. The purpose of this study was to elucidate individual functions or the functional relationship between the projections. Our results showed that the oxytocin receptor-expressing neurons in the prefrontal cortex includes projection neurons other than somatostatin-positive interneurons. In addition, we used retrograde infection of AAV vectors to investigate the projection pattern of oxytocin receptor-expressing neurons in the paraventricular nucleus.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、社会性に関わるホルモンとして知られるオキシトシンの効果がなぜ多様に変化しうるのかを調べたものです。オキシトシンを作り出す神経は脳内の様々な場所に繋がっています。この繋がりは複雑ですが、遺伝学的な手法を駆使することでそれを解きほぐすことができてきました。今後は得られた知見を基に、それぞれの繋がりがどんなはたらきをしているのかを明らかにします。
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Report
(5 results)
Research Products
(22 results)
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[Journal Article] Sex differences in olfactory-induced neural activation of the amygdala.2018
Author(s)
Kikusui T, Kajita M, Otsuka N, Hattori T, Kumazawa K, Watarai A, Nagasawa M, Inutsuka A, Yamanaka A, Matsuo N, Covington HE 3rd, Mogi K.
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Journal Title
Behav Brain Res.
Volume: 27
Pages: 96-104
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Top-down cortical input during nrem sleep consolidates perceptual memory.2016
Author(s)
Miyamoto D, Hirai D, Fung CC, Inutsuka A, Odagawa M, Suzuki T, Boehringer R, Adaikkan C, Matsubara C, Matsuki N, Fukai T, McHugh TJ, Yamanaka A, *Murayama M
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Journal Title
Science
Volume: 352
Issue: 6291
Pages: 1315-1318
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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