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The effect of maternal experiences on spatial learning and hippocampal neural plasticity

Research Project

Project/Area Number 16K08531
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionSt. Marianna University School of Medicine

Principal Investigator

Nagatani Miyako  聖マリアンナ医科大学, 医学部, 准教授 (20450611)

Co-Investigator(Kenkyū-buntansha) 福島 篤  聖マリアンナ医科大学, 医学部, 講師 (10442716)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords妊娠 / 出産 / 子育て / 海馬 / AMPA / AMPA受容体 / 生殖イベント / LTP / 飽和試験 / 学習 / 雌性ラット / 可塑性 / 生理学 / 神経科学
Outline of Final Research Achievements

To distinguish the role of each maternal event in the development of working memory, we established four experimental groups of nulliparity control, nulliparity with experience of rearing foster pups, primiparity without the rearing experience, and primiparity with all maternal events of pregnancy, delivery, lactation and rearing. Those rats were subjected to the Y-maze test for spatial learning assessments. We then used a protocol to induce LTP by using a whole-cell recording to pair low-frequency synaptic stimulation with a depolarizing voltage-clamp pulse. The present study revealed that primiparity showed a higher % induction of LTP level, RI, AMPA/NMDA ratio and the score of spatial learning than the nullparity control. However, there was no significant difference in the expression of 14-3-3 protein between the four groups. Taken together, reproductive experience could change the subunit composition of synaptic AMPA receptors leading to improved spatial learning.

Academic Significance and Societal Importance of the Research Achievements

授乳期以降のラットを用いた研究は、報告が少なく、エストロジェン濃度変動に依存しAMPA受容体の構成に変化がみられることから、性周期を明確にした研究を行っている点、AMPA受容体に関する研究は、雄性ラットの研究が主で、経産ラットを用いた研究はないという点から学術的意義がある。生殖イベント全ての経験が顕著に可塑的変化をもたらし、経産ラットの空間学習の成績と海馬内のAMPA受容体のサブユニット構成の変化に14-3-3proteinは関与が低いことを示唆する結果となった。これらの結果は、少子化、子供への虐待問題を抱えている日本では、科学以外の場で注目されることも予想され、社会的にも意義ある研究である。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2019 2018 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (8 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Short-term fasting decreases excitatory synaptic inputs to ventromedial tuberoinfundibular dopaminergic neurons and attenuates their activity in male mice.2018

    • Author(s)
      Kubota T, Fukushima A, Hagiwara H, Kamiya Y, Furuta M, Miyazaki T, Fujioka H, Fujiwara SE, Funabashi T, Akema T.
    • Journal Title

      Neurosci Lett.

      Volume: 10 (671) Pages: 70-75

    • DOI

      10.1016/j.neulet.2018.02.017

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Effects of the experience of pregnancy-delivery-nurturing on excitatory synaptic inputs to tuberoinfundibular dopaminergic neurons2019

    • Author(s)
      Furuta M, Kakehashi C, Funabashi T
    • Organizer
      The 49th Society for Neuroscience
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of maternal experiences on spatial learning and hippocampal neural plasticity. ◎2018

    • Author(s)
      Furuta M, Fukushima A, Akema T ,Funabashi T
    • Organizer
      The 48th Society for Neuroscience
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 妊娠、出産、子育て経験後の学習機能とAMPA受容体サブユニットの構成の変化2018

    • Author(s)
      古田 都、明間 立雄、舩橋 利也
    • Organizer
      第45回日本神経内分泌学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 妊娠-出産-子育ての経験が視床下部TIDAニューロンへの興奮性シナプス入力へ及ぼす影響2017

    • Author(s)
      古田都
    • Organizer
      第94回日本生理学会大会(
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2017-03-30
    • Related Report
      2016 Research-status Report
  • [Presentation] マウス中枢神経系のPDGFRα系を介する摂食調節作用は、末梢とは異なる2017

    • Author(s)
      福島篤
    • Organizer
      第12回環境生理学プレコングレス
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2017-03-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 妊娠-出産-子育て経験による視床下部TIDAニューロンへの興奮性シナプス入力への影響2017

    • Author(s)
      古田都、福島篤、舩橋利也
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 視床下部PDGF受容体αを介した摂食調節作用に関する研究2016

    • Author(s)
      福島篤
    • Organizer
      第43回日本神経内分泌学会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2016-10-15
    • Related Report
      2016 Research-status Report
  • [Presentation] 幼弱期雌性ラットにおけるニコチン投与および母性様行動の成体期における母性行動と空間学習に及ぼす影響2016

    • Author(s)
      古田都
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-21
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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