Identification of interrelationships between hypoxia in tumor and biological clock for chronotherapy
| Project/Area Number |
16K08532
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | circadian / sleep / hypoxia / 低酸素 / 行動リズム / 時計遺伝子 / 担癌マウス / 癌 / 生物リズム / 腫瘍低酸素 / 概日リズム / 生物時計 |
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| Outline of Final Research Achievements |
To know relationships between tumor hypoxia and behavior rhythm of host, mice were exposed to hypoxia of different timings in a day. The largest response were observed by daytime hypoxia (DHx). DHx reduced activity of active phase and increased activity ending phase. This biphasic response was occurred by overlap between active phase and clock gene independent wave like response by DHx. In addition, this biphasic response was involved in sleep substance increased by DHx. And, another factor increased by DHx acted against the effect of DHx.
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| Academic Significance and Societal Importance of the Research Achievements |
休息期の低酸素により行動の2相性の変化、波様反応が起こることを初めて明らかにした。これは休息期の低酸素による病態（睡眠時無呼吸症候群、高山病の睡眠後の悪化）を理解するために有用である。特に治療抵抗性である睡眠時無呼吸症候群（Co-Morbid Insomnia and Sleep Apnea, COMISA)ではマウスの行動に対応した昼間の強い眠気と夜間の不眠が起こることから我々の研究結果から得られる示唆が多いと思われる。
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Report
(5 results)
Research Products
(23 results)
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[Presentation] Hypoxia effect on daily activity is daily activity dependent wavelike response in mice2019
Author(s)
Satoru Masubuchi , Takako Yano , Kouji Komatsu , Wataru Nakamura , Akinobu Ota, Sivasundaram Karnan, Kosei Takeuchi , Yoshitaka Hosokawa, Takeshi Todo, Kazuo Umezawa, Toshiaki Shiomi
Organizer
FAOPS2019
Related Report
Int'l Joint Research
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[Presentation] Hypoxia effect on circadian activity is molecular clock independent but daily activity dependent wave like response in mice2018
Author(s)
Satoru Masubuchi , Takako Yano , Kouji Komatsu , Wataru Nakamura , Akinobu Ota, Sivasundaram Karnan, Kosei Takeuchi , Yoshitaka Hosokawa, Takeshi Todo, Kazuo Umezawa, Toshiaki Shiomi
Organizer
Asian Forum on Chronobiology in 2018
Related Report
Int'l Joint Research
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[Presentation] Hypoxia effect on daily activity is molecular clock independent but daily activity dependent wave like response in mice2018
Author(s)
Satoru Masubuchi , Takako Yano , Kouji Komatsu , Wataru Nakamura , Akinobu Ota, Sivasundaram Karnan, Kosei Takeuchi , Yoshitaka Hosokawa, Takeshi Todo, Kazuo Umezawa, Toshiaki Shiomi
Organizer
International Symposium on Biological Rhythms “20 Years since Discovery of mammalian Clock Genes”
Related Report
Int'l Joint Research
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