| Project/Area Number |
16K08536
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
久米 典昭 神戸学院大学, 薬学部, 教授 (20252455)
西 英一郎 滋賀医科大学, 医学部, 教授 (30362528)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 概日時計 / 時計遺伝子 / 転写制御 / 概日リズム |
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| Outline of Final Research Achievements |
Nardilysin (N-arginine dibasic convertase; NRDC) is a zinc peptidase of the M16 family. We have reported that NRDC has multiple functions, which depend on its cellular localization. In the extracellular space, NRDC enhances ectodomain shedding of a variety of membrane proteins. On the other hand, NRDC in the nucleus works as a transcriptional coregulator. These findings suggest important roles of NRDC in various homeostasis in vivo. To evaluate the role of NRDC in the nucleus in more detail, we performed ChIP-seq of NRDC in mouse liver. ChIP-seq and motif analysis of the NRDC-binding sites revealed a significant enrichment for E-box motif. Thus, we investigated the role of NRDC on the mammalian circadian clock in the present study.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで生物時計とは何の関連も指摘されていなかったNRDCが、概日リズムを制御する新規時計調節因子である可能性を見出した。
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