Development of highly functional molecular target drug that enables clinical practice of malignant melanoma using combined immunotherapy
| Project/Area Number |
16K08542
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Chiba University |
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Principal Investigator |
SUGANAMI Akiko 千葉大学, 大学院医学研究院, 助教 (10527922)
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| Co-Investigator(Kenkyū-buntansha) |
白澤 浩 千葉大学, 大学院医学研究院, 教授 (00216194)
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| Research Collaborator |
Kumar P. K. R.
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 光免疫誘導 / リポソーム / 免疫抑制解除 / ペプチド医薬 / 薬理学 / がん / 核酸 / 脂質 / 生体機能利用 |
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| Outline of Final Research Achievements |
In this study, we constructed a liposome which can regulate cancer immunoediting mechanism, designated as CIR Liposomes, by having photoimmune induction function, immune adjuvant function and immune checkpoint recognition function.
We evaluated the immunosuppressive functional control on antigen-specific recognition of CIR Liposomes using tumor-bearing mice, and found that tumor volume change was significantly suppressed.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の学術的意義は，これまでに培ってきた「がん微小環境の制御」「がん幹細胞の制御」に関する知見を礎にして，現状の「がん免疫療法」が抱える問題点を解決すべく，がん免疫編集機構（Cancer Immunoediting）の制御（Regulate）を目的とした“Cancer Immunoediting Regulateリポソーム”を構築したところにある．
また，社会的意義としては，実臨床を視野に入れたトランスレーショナルリサーチに関する研究展開として，獣医師主導型臨床試験における効果の検証とフィードバックにより，患者に優しい非侵襲性治療として「がん複合免疫療法」の創生を目指したところにある．
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] The pluripotent stem-cell marker alkaline phosphatase is highly expressed in refractory glioblastoma with DNA hypomethylation.2017
Author(s)
Iwadate, Y., Suganami, A., Tamura, Y., Matsutani, T., Hirono, S., Shinozaki, N., Hiwasa, T., Takiguchi, M., and Saeki, N.
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Journal Title
Neurosurgery
Volume: 80
Issue: 2
Pages: 248-248
DOI
Related Report
Peer Reviewed
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