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Development of highly functional molecular target drug that enables clinical practice of malignant melanoma using combined immunotherapy

Research Project

Project/Area Number 16K08542
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General pharmacology
Research InstitutionChiba University

Principal Investigator

SUGANAMI Akiko  千葉大学, 大学院医学研究院, 助教 (10527922)

Co-Investigator(Kenkyū-buntansha) 白澤 浩  千葉大学, 大学院医学研究院, 教授 (00216194)
Research Collaborator Kumar P. K. R.  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords光免疫誘導 / リポソーム / 免疫抑制解除 / ペプチド医薬 / 薬理学 / がん / 核酸 / 脂質 / 生体機能利用
Outline of Final Research Achievements

In this study, we constructed a liposome which can regulate cancer immunoediting mechanism, designated as CIR Liposomes, by having photoimmune induction function, immune adjuvant function and immune checkpoint recognition function.
We evaluated the immunosuppressive functional control on antigen-specific recognition of CIR Liposomes using tumor-bearing mice, and found that tumor volume change was significantly suppressed.

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的意義は,これまでに培ってきた「がん微小環境の制御」「がん幹細胞の制御」に関する知見を礎にして,現状の「がん免疫療法」が抱える問題点を解決すべく,がん免疫編集機構(Cancer Immunoediting)の制御(Regulate)を目的とした“Cancer Immunoediting Regulateリポソーム”を構築したところにある.
また,社会的意義としては,実臨床を視野に入れたトランスレーショナルリサーチに関する研究展開として,獣医師主導型臨床試験における効果の検証とフィードバックにより,患者に優しい非侵襲性治療として「がん複合免疫療法」の創生を目指したところにある.

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (20 results)

All 2018 2017 2016 Other

All Journal Article (10 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 10 results,  Open Access: 6 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) Remarks (2 results)

  • [Journal Article] Synthesis and Evaluation of Fuligocandin B Derivatives with Activity for Overcoming TRAIL Resistance2018

    • Author(s)
      Arai Midori A.、Masuda Ayaka、Suganami Akiko、Tamura Yutaka、Ishibashi Masami
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 66 Issue: 8 Pages: 810-817

    • DOI

      10.1248/cpb.c18-00308

    • NAID

      130007429518

    • ISSN
      0009-2363, 1347-5223
    • Year and Date
      2018-08-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibitory effect of Japanese rice-koji miso extracts on hepatitis A virus replication in association with the elevation of glucose-regulated protein 78 expression2018

    • Author(s)
      Win Nan Nwe、Kanda Tatsuo、Nakamoto Shingo、Moriyama Mitsuhiko、Jiang Xia、Suganami Akiko、Tamura Yutaka、Okamoto Hiroaki、Shirasawa Hiroshi
    • Journal Title

      International Journal of Medical Sciences

      Volume: 15 Issue: 11 Pages: 1153-1159

    • DOI

      10.7150/ijms.27489

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] GLI1 Inhibitors Identified by Target Protein Oriented Natural Products Isolation (TPO-NAPI) with Hedgehog Inhibition2018

    • Author(s)
      Arai Midori A.、Ochi Fumie、Makita Yoshinori、Chiba Tetsuhiro、Higashi Kyohei、Suganami Akiko、Tamura Yutaka、Toida Toshihiko、Iwama Atsushi、Sadhu Samir K.、Ahmed Firoj、Ishibashi Masami
    • Journal Title

      ACS Chemical Biology

      Volume: 13 Issue: 9 Pages: 2551-2559

    • DOI

      10.1021/acschembio.8b00492

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Deletion of Eqtn in mice reduces male fertility and sperm-egg adhesion2018

    • Author(s)
      Ito Chizuru、Yamatoya Kenji、Yoshida Keiichi、Fujimura Lisa、Sugiyama Hajime、Suganami Akiko、Tamura Yutaka、Hatano Masahiko、Miyado Kenji、Toshimori Kiyotaka
    • Journal Title

      Reproduction

      Volume: 156 Issue: 6 Pages: 579-590

    • DOI

      10.1530/rep-18-0394

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Photo-immune therapy with liposomally formulated phospholipid-conjugated indocyanine green induces specific antitumor responses with heat shock protein-70 expression in a glioblastoma model2018

    • Author(s)
      Shibata Sayaka、Shinozaki Natsuki、Suganami Akiko、Ikegami Shiro、Kinoshita Yuki、Hasegawa Ryozo、Kentaro Hirata、Okamoto Yoshiharu、Aoki Ichio、Tamura Yutaka、Iwadate Yasuo
    • Journal Title

      Oncotarget

      Volume: 10 Issue: 2 Pages: 175-183

    • DOI

      10.18632/oncotarget.26544

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-cancer Effects of MW-03, a Novel Indole Compound, by Inducing 15-Hydroxyprostaglandin Dehydrogenase and Cellular Growth Inhibition in the LS174T Human Colon Cancer Cell Line2017

    • Author(s)
      Seira Naofumi、Yanagisawa Naoki、Suganami Akiko、Honda Takuya、Wasai Makiko、Regan John W.、Fukushima Keijo、Yamaguchi Naoto、Tamura Yutaka、Arai Takayoshi、Murayama Toshihiko、Fujino Hiromichi
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 40 Issue: 10 Pages: 1806-1812

    • DOI

      10.1248/bpb.b17-00458

    • NAID

      130006110584

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] PGE1 and E3 show lower efficacies than E2 to β-catenin-mediated activity as biased ligands of EP4 prostanoid receptors2017

    • Author(s)
      Araki Yumi、Suganami Akiko、Endo Suzu、Masuda Yuta、Fukushima Keijo、Regan John W.、Murayama Toshihiko、Tamura Yutaka、Fujino Hiromichi
    • Journal Title

      FEBS Lett.

      Volume: 591 Issue: 22 Pages: 3771-3780

    • DOI

      10.1002/1873-3468.12878

    • NAID

      130007900719

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The pluripotent stem-cell marker alkaline phosphatase is highly expressed in refractory glioblastoma with DNA hypomethylation.2017

    • Author(s)
      Iwadate, Y., Suganami, A., Tamura, Y., Matsutani, T., Hirono, S., Shinozaki, N., Hiwasa, T., Takiguchi, M., and Saeki, N.
    • Journal Title

      Neurosurgery

      Volume: 80 Issue: 2 Pages: 248-248

    • DOI

      10.1093/neuros/nyw026

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of novel small compounds targeting TrkB on neuronal cell survival and depression-like behavior.2016

    • Author(s)
      Fukuda M, Takatori A, Nakamura Y, Suganami A, Hoshino T, Tamura Y, Nakagawara A
    • Journal Title

      Neurochemistry International

      Volume: 97 Pages: 42-48

    • DOI

      10.1016/j.neuint.2016.04.017

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Human DP and EP2 prostanoid receptors take on distinct forms depending on the diverse binding of different ligands.2016

    • Author(s)
      Suganami A, Fujino H, Okura I, Yanagisawa N, Sugiyama H, Regan JW, Tamura Y, Murayama T.
    • Journal Title

      FEBS J.

      Volume: 283 Issue: 21 Pages: 3931-3940

    • DOI

      10.1111/febs.13899

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] インドシアニングリーン修飾リポソームと光を用いた新しいがん治療2018

    • Author(s)
      岡本 芳晴、田村 裕、菅波 晃子、山下 真路、東 和生、大崎 智弘、村端 悠介、柄 武士、伊藤 典彦、今川 智敬
    • Organizer
      第56回日本癌治療学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] NICDビーズを用いたNotchシグナル阻害剤の探索2018

    • Author(s)
      林奈留美,荒井緑,菅波晃子,田村裕,石橋正己
    • Organizer
      第22回天然薬物の開発と応用シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] リグナン骨格を有する神経幹細胞分化促進剤の創成研究2018

    • Author(s)
      三瓶 真菜, 荒井 緑, 菅波 晃子, 田村 裕, 石橋 正己
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Research-status Report
  • [Presentation] NICDビーズを用いたNotchシグナル阻害剤の探索2018

    • Author(s)
      林 奈留美, 荒井 緑, 菅波 晃子, 田村 裕, 石橋 正己
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Research-status Report
  • [Presentation] Human DP and EP2 prostanoid receptors take on distinct forms depending on the diverse binding of different ligands2017

    • Author(s)
      Fujino H, Suganami A, Okura I, Yanagisawa N, Sugiyama H, Regan, J. W., Mizuguchi H, Tamura Y, Murayama T.
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール,長崎新聞文化ホール
    • Year and Date
      2017-03-15
    • Related Report
      2016 Research-status Report
  • [Presentation] Combination therapy of anti-cancer drugs with photo-induced immunotherapy2017

    • Author(s)
      Suganami A, Yamashita M, Azuma K, Okamoto Y, Tamura Y
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Construction of the multifunctional nanoparticle for malignant melanoma2016

    • Author(s)
      Suganami A, P. K. R. Kumar, Shinoda K, Suzuki A, Saito K, Okamoto Y, Motohashi S, Nakayama T, Shirakawa H, Tamura Y.
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Molecular mechanism of DA-Raf-mediated Ras-ERK cascade inhibition2016

    • Author(s)
      Takano K, Kanno E, Suganami A, Tamara Y, Endo T.
    • Organizer
      第68回日本細胞生物学会大会
    • Place of Presentation
      京都テルサ
    • Year and Date
      2016-06-15
    • Related Report
      2016 Research-status Report
  • [Remarks] 千葉大学大学院医学研究院 生命情報科学

    • URL

      http://www.m.chiba-u.ac.jp/class/bioinfor/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 千葉大学大学院医学研究院生命情報科学

    • URL

      http://www.m.chiba-u.ac.jp/class/bioinfor/index.html

    • Related Report
      2017 Research-status Report 2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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