| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Dysfunction of Progranulin by gene mutation is thought to cause Frontotemporal dementia. However, its molecular mechanism is still not well understood, and the progranulin receptor involved in the onset is also unknown. In this study, I attempted to identify Pogranulin receptors and binding molecules involved in the onset of FTD, and found some novel binding partners. Furthermore, interaction with Progranulin induced lysosomal degradation of these binding molecules. These results suggest that Progranulin may be involved in neuroprotective function control via these new binding molecules.
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