Molecular function of DR6 for controlling peripheral immunological cells

• Project/Area Number: 16K08570
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Kitasato University (2019); Asahikawa Medical College (2016-2018)
• Principal Investigator: Fujikura Daisuke 北里大学, 獣医学部, 特任准教授 (70547794)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: DR6 / SLE / T細胞 / 末梢免疫細胞 / Death Receptor 6 / Syndecan / B細胞

Outline of Final Research Achievements

Activation of peripheral T cells is tightly restricted to prevent induction of auto immunological diseases, such as systemic lupus erythematosus (SLE). Here we report molecular details of an orphan immune regulator, death receptor 6 (DR6/TNFRSF21) in lupus-like disease progression in mice.

Academic Significance and Societal Importance of the Research Achievements

本研究成果により、自己免疫性炎症性疾患の一つである全身性エリテマトーデスのモデルマウス病態発症制御において、DR6分子を介したメカニズムの存在が示唆された。本知見から、DR6分子が上記疾患の治療標的の一つとなりうる可能性が示唆された。

Research Products

• [Journal Article] Inactivated whole virus particle vaccine with potent immunogenicity and limited IL-6 production is ideal for influenza (2019)
  • Author(s): Sekiya T, Mifsud EJ, Ohno M, Nomura N, Sasada M, Fujikura D, Daito T, Shingai M, Ohara Y, Nishimura T, Endo M, Mitsumata R, Ikeda T, Hatanaka H, Kitayama H, Motokawa K, Sobue T, Suzuki S, Itoh Y, Brown LE, Ogasawara K, Kino Y, Kida H
  • Journal Title: Vaccine Volume: 37 Issue: 15 Pages: 2158-2166
  • DOI: 10.1016/j.vaccine.2019.02.057
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Development and application of a Bacillus anthracis protective antigen domain-1 in-house ELISA for the detection of anti-protective antigen antibodies in cattle in Zambia (2018)
  • Author(s): Simbotwe Manyando、Fujikura Daisuke、Ohnuma Miyuki、Omori Ryosuke、Furuta Yoshikazu、Muuka Geoffrey Munkombwe、Hang’ombe Bernard Mudenda、Higashi Hideaki
  • Journal Title: PLOS ONE Volume: 13 Issue: 10 Pages: e0205986-e0205986
  • DOI: 10.1371/journal.pone.0205986
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Programmed Cell Death in the Pathogenesis of Influenza (2018)
  • Author(s): Fujikura Daisuke、Miyazaki Tadaaki
  • Journal Title: International Journal of Molecular Sciences Volume: 19 Issue: 7 Pages: 2065-2065
  • DOI: 10.3390/ijms19072065
  • Peer Reviewed
• [Journal Article] Single-Nucleotide Polymorphisms in Human NPC1 Influence Filovirus Entry Into Cells (2018)
  • Author(s): Kondoh Tatsunari、Letko Michael、Munster Vincent J、Manzoor Rashid、Maruyama Junki、Furuyama Wakako、Miyamoto Hiroko、Shigeno Asako、Fujikura Daisuke、Takadate Yoshihiro、Yoshida Reiko、Igarashi Manabu、Feldmann Heinz、Marzi Andrea、Takada Ayato
  • Journal Title: The Journal of Infectious Diseases Volume: 218 Issue: suppl_5 Pages: S397-S402
  • DOI: 10.1093/infdis/jiy248
  • NAID: 120006773326
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Brazilian propolis ethanol extract and its component kaempferol induce myeloid-derived suppressor cells from macrophages of mice in vivo and in vitro (2018)
  • Author(s): Kitamura Hiroshi、Saito Natsuko、Fujimoto Junpei、Nakashima Ken-ichi、Fujikura Daisuke
  • Journal Title: BMC Complementary and Alternative Medicine Volume: 18 Issue: 1 Pages: 138-138
  • DOI: 10.1186/s12906-018-2198-5
  • NAID: 120006798131
  • Peer Reviewed / Open Access
• [Journal Article] Aureobasidium pullulans-cultured fluid induces IL-18 production, leading to Th1-polarization during influenza A virus infection (2017)
  • Author(s): Fujikura Daisuke、Muramatsu Daisuke、Toyomane Kochi、Chiba Satoko、Daito Takuji、Iwai Atsushi、Kouwaki Takahisa、Okamoto Masaaki、Higashi Hideaki、Kida Hiroshi、Oshiumi Hiroyuki
  • Journal Title: The Journal of Biochemistry Volume: 163 Issue: 1 Pages: 31-38
  • DOI: 10.1093/jb/mvx062
  • NAID: 40021457359
  • Peer Reviewed
• [Journal Article] Characterization of a Novel Bat Adenovirus Isolated from Straw-Colored Fruit Bat (Eidolon helvum) (2017)
  • Author(s): Ogawa Hirohito、Kajihara Masahiro、Nao Naganori、Shigeno Asako、Fujikura Daisuke、Hang’ombe Bernard、Mweene Aaron、Mutemwa Alisheke、Squarre David、Yamada Masao、Higashi Hideaki、Sawa Hirofumi、Takada Ayato
  • Journal Title: Viruses Volume: 9 Issue: 12 Pages: 371-371
  • DOI: 10.3390/v9120371
  • NAID: 120006382305
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Putative endogenous filovirus VP35-like protein potentially functions as an IFN antagonist but not a polymerase cofactor (2017)
  • Author(s): Kondoh Tatsunari、Manzoor Rashid、Nao Naganori、Maruyama Junki、Furuyama Wakako、Miyamoto Hiroko、Shigeno Asako、Kuroda Makoto、Matsuno Keita、Fujikura Daisuke、Kajihara Masahiro、Yoshida Reiko、Igarashi Manabu、Takada Ayato
  • Journal Title: PLOS ONE Volume: 12 Issue: 10 Pages: e0186450-e0186450
  • DOI: 10.1371/journal.pone.0186450
  • NAID: 120006366507
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Death receptor 6 contributes to autoimmunity in lupus-prone mice. (2017)
  • Author(s): Fujikura D, Ikesue M, Endo T, Chiba S, Higashi H and Uede T
  • Journal Title: Nature Communications Volume: 8:13957 Issue: 1 Pages: 1-11
  • DOI: 10.1038/ncomms13957
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] ANTXR-1 and -2 independent modulation of a cytotoxicity mediated by anthrax toxin in human cells (2016)
  • Author(s): Fujikura D, Toyomane K, Kamiya K, Mutoh M, Mifune E, Ohnuma M and Higashi H
  • Journal Title: Journal of Veterinary Medical Science Volume: 78 Issue: 8 Pages: 1311-1317
  • DOI: 10.1292/jvms.15-0727
  • NAID: 130005261508
  • ISSN: 0916-7250, 1347-7439
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] ヒト狼瘡動物モデルNZB/W F1マウスの発症におけるDeath receptor 6の関与 (2017)
  • Author(s): 藤倉大輔
  • Organizer: 第14回北海道実験動物研究会総会・学術集会