| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The A subunit of coagulation factor XIII (FXIII-A) is a plasma transglutaminase (TGase), which exists not only in plasma but also inside bone marrow-derived cells such as megakaryocytes, and was found to possibly modify nuclear proteins with amines. A nuclear protein was determined as a substrate for FXIII-A in the present study. Studies using FXIII-A- and/or tissue TGase deficient mice exhibited that (1) FXIII-A contributed to the modification of nuclear proteins in megakaryocytes, (2) FXIII-A controlled differentiation of megakaryocytes, (3) a FXIII-A substrate increased during differentiation of megakaryocytes which was suppressed by FXIII-A.
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