Regulation of membrane domain functions by lipid transport and lipid metabolism in cancer cells
| Project/Area Number |
16K08618
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
Yamauchi Yoshio 東京大学, 大学院農学生命科学研究科(農学部), 准教授 (00444878)
|
|---|
| Project Period (FY) |
2016-04-01 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 脂質代謝 / 細胞内輸送 / コレステロール / スフィンゴ脂質 / 細胞内脂質輸送 / がん / 膜ドメイン / 脂質輸送 / 癌 / 脂質 / 発現制御 / 代謝 |
|---|
| Outline of Final Research Achievements |
Lipid rafts, membrane domains rich in cholesterol and sphingolipids, play diverse and important roles in malignant properties of cancer cells. However, a regulatory mechanism for functions of the membrane domains remains poorly understood. In this work, we studied mechanisms by which intracellular lipid transport and lipid metabolism cooperatively regulate functionality of lipid rafts in cancer cells. Our results showed that intracellular transport of cholesterol and sphingolipids regulates lipid biosynthesis and integrity of lipid rafts, supporting malignant properties of cancer cells.
|
| Academic Significance and Societal Importance of the Research Achievements |
がん細胞では特徴的な代謝変化がしばしば認められ、この性質はがん細胞の悪性形質に深く関与している。がん細胞における脂質合成の亢進は、このような代謝的な特徴の一つである。また、オンコジェニックシグナルの活性化において、脂質ラフトと呼ばれるコレステロールおよびスフィンゴ脂質を豊富に含む膜ドメインが重要な役割を果たしている。本研究課題では、コレステロールを中心とする脂質合成と脂質ラフト構成脂質の細胞内輸送が膜ドメイン機能を調節していることを明らかにし、がん細胞における脂質代謝の重要性の一端を明らかにした。
|
Report
(5 results)
Research Products
(30 results)
-
-
-
-
-
-
-
-
-
[Journal Article] Raft-based interactions of gangliosides with a GPI-anchored receptor2016
Author(s)
N. Komura, K. G. N. Suzuki, H. Ando, M. Konishi, M. Koikeda, A. Imamura, R. Chadda, T. K. Fujiwara, H. Tsuboi, R. Sheng, W. Cho, K. Furukawa, K. Furukawa, Y. Yamauchi, H. Ishida, A. Kusumi (Co-Corresponding Author), and M. Kiso
-
Journal Title
Nat. Chem. Biol.
Volume: in press
Issue: 6
Pages: 402-410
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] Expression analysis of 0-series gangliosides in human cancer cell lines with monoclonal antibodies generated using knockout mice of ganglioside synthase genes2016
Author(s)
Bhuiyan RH, Kondo Y, Yamaguchi T, Tokuda N, Ohkawa Y, Hashimoto N, Ohmi Y, Yamauchi Y, Furukawa K, Okajima T, Furukawa K
-
Journal Title
Glycobiology
Volume: 26
Issue: 9
Pages: 984-998
DOI
Related Report
Peer Reviewed
-
[Journal Article] Increased expression levels of ppGalNAc-T13 in lung cancers: Significance in the prognostic diagnosis2016
Author(s)
Nogimori K, Hori T, Kawaguchi K, Fukui T, Mii S, Nakada H, Matsumoto Y, Yamauchi Y, Takahashi M, Furukawa K, Tetsuya O, Yokoi K, Hasegawa Y, Furukawa K
-
Journal Title
Int J Oncol
Volume: 49
Issue: 4
Pages: 1369-1376
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
