| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
RNA-seq analysis was performed on cells in a state in which cancer-initiating cells (CICs) were likely to cause plasticity and in a state in which CICs were not easily induced using endometrioid carcinoma cell lines. Glycoprotein M6B (GPM6B) found in a state in which plasticity was likely to occur was immunohistochemically expressed in agreement with the ALDH-positive area in endometrioid carcinoma cases. When sarcosine, which was produced from glycine by glycine N-methyltransferase, which was expressed in a state that was difficult to induce CICs, was administered to cancer cell lines, the proportion of cells with high ALDH activity was decreased in a concentration-dependent manner. It was suggested that these factors might be involved in the control of CIC plasticity.
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