Analysis of plasticity of cancer-initiating cells in malignant tumors

• Project/Area Number: 16K08649
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Chiba University (2018); Osaka University (2016-2017)
• Principal Investigator: Ikeda Jun-ichiro 千葉大学, 大学院医学研究院, 教授 (20379176)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 腫瘍幹細胞 / 病理学 / 子宮内膜癌 / アルデヒド脱水素酵素 / 可塑性 / 癌

Outline of Final Research Achievements

RNA-seq analysis was performed on cells in a state in which cancer-initiating cells (CICs) were likely to cause plasticity and in a state in which CICs were not easily induced using endometrioid carcinoma cell lines. Glycoprotein M6B (GPM6B) found in a state in which plasticity was likely to occur was immunohistochemically expressed in agreement with the ALDH-positive area in endometrioid carcinoma cases. When sarcosine, which was produced from glycine by glycine N-methyltransferase, which was expressed in a state that was difficult to induce CICs, was administered to cancer cell lines, the proportion of cells with high ALDH activity was decreased in a concentration-dependent manner. It was suggested that these factors might be involved in the control of CIC plasticity.

Academic Significance and Societal Importance of the Research Achievements

腫瘍の中には化学療法や放射線療法に抵抗性で，再発や転移の原因になるとされる「腫瘍幹細胞」と呼ばれる細胞群が存在し，「腫瘍幹細胞」の制御ががん治療の重要な鍵となっている．従来，「腫瘍幹細胞」から「腫瘍幹細胞」と「非腫瘍幹細胞」が生み出され，「非腫瘍幹細胞」から「腫瘍幹細胞」にはならないとされてきたが，「非腫瘍幹細胞」が「腫瘍幹細胞」に転換しうる「可塑性」を有することが報告され，治療を考える上でより複雑な状況になってきている．この可塑性のメカニズムを解明することでがん治療への応用につながる可能性があり，本研究成果は学術的にも社会的にも意義あるものと考える．

Research Products

• [Journal Article] SDPR Regulates ALDH1 via ILK Signaling in Endometrioid Carcinoma Cells. (2019)
  • Author(s): Tahara S, Nojima S, Ohshima K, Hori Y, Kurashige M, Wada N, Motoyama Y, Okuzaki D, Ikeda JI, Morii E.
  • Journal Title: Cancer Sci. Volume: in press Issue: 5 Pages: 1804-1813
  • DOI: 10.1111/cas.14007
  • Peer Reviewed / Open Access
• [Journal Article] Systematic diagnostics of the electrical, optical, and physicochemical characteristics of low-temperature atmospheric-pressure helium plasma sources. (2019)
  • Author(s): Takeda K, Yamada H, Ishikawa K, Sakakita H, Kim J, Ueda M, Ikeda JI, Akimoto Y, Kataoka Y, Yokoyama N, Ikehara Y, Hori M
  • Journal Title: Journal of Physics D: Applied Physics Volume: -
  • Peer Reviewed
• [Journal Article] Predictive value of MLH1 and PD-L1 expression for prognosis and response to preoperative chemotherapy in gastric cancer. (2019)
  • Author(s): Hashimoto T, Kurokawa Y, Takahashi T, Miyazaki Y, Tanaka K, Makino T, Yamasaki M, Nakajima K, Ikeda JI, Mori M, Doki Y
  • Journal Title: Gastric Cancer Volume: - Issue: 4 Pages: 785-792
  • DOI: 10.1007/s10120-018-00918-4
  • NAID: 40021925981
  • Peer Reviewed
• [Journal Article] Cascade Reaction in Human Live Tissue Allows Clinically Applicable Diagnosis of Breast Cancer Morphology (2018)
  • Author(s): Tanei Tomonori、Pradipta Ambara R.、Morimoto Koji、Fujii Motoko、Arata Mayumi、Ito Akihiro、Yoshida Minoru、Saigitbatalova Elena、Kurbangalieva Almira、Ikeda Jun-ichiro、Morii Eiichi、Noguchi Shinzaburo、Tanaka Katsunori
  • Journal Title: Advanced Science Volume: 6 Issue: 2 Pages: 1801479-1801479
  • DOI: 10.1002/advs.201801479
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of glutamine on lymphoplasmacytic lymphoma, especially on the viewpoint of the differentiation into vulnerable subpopulation. (2018)
  • Author(s): Wada N, Nojima S, Tahara SI, Ohshima K, Kurashige M, Kawasaki K, Tone M, Kusumoto S, Ikeda JI, Morii E.
  • Journal Title: Pathol Res Pract Volume: 214 Issue: 10 Pages: 1667-1674
  • DOI: 10.1016/j.prp.2018.08.019
  • Peer Reviewed / Open Access
• [Journal Article] Origin of cancer-associated fibroblasts and tumor-associated macrophages in humans after sex-mismatched bone marrow transplantation. (2018)
  • Author(s): Kurashige M, Kohara M, Ohshima K, Tahara S, Hori Y, Nojima S, Wada N, Ikeda JI, Miyamura K, Ito M, Morii E.
  • Journal Title: Commun Biol. Volume: 1 Issue: 1 Pages: 131-131
  • DOI: 10.1038/s42003-018-0137-0
  • Peer Reviewed / Open Access
• [Journal Article] Effect of plasma-activated medium produced by direct irradiation on cancer cell killing. (2018)
  • Author(s): Uchida G, Ito T, Ikeda J, Suzkuki T, Takenaka K, Setsuhara Y
  • Journal Title: Japanese Journal of Applied Physics Volume: 57 Pages: 096201-096201
  • NAID: 210000149639
  • Peer Reviewed
• [Journal Article] Mutational Analysis of AKT1 and PIK3CA in Intraductal Papillomas of the Breast with Special Reference to Cellular Components (2018)
  • Author(s): Mishima Chieko、Kagara Naofumi、Ikeda Jun-ichiro、Morii Eiichi、Miyake Tomohiro、Tanei Tomonori、Naoi Yasuto、Shimoda Masafumi、Shimazu Kenzo、Kim Seung J.、Noguchi Shinzaburo
  • Journal Title: Am J Pathol Volume: in press Issue: 5 Pages: 1106-1112
  • DOI: 10.1016/j.ajpath.2018.01.005
  • Peer Reviewed
• [Journal Article] Adenylosuccinate lyase enhances aggressiveness of endometrial cancer by increasing killer cell lectin-like receptor C3 expression by fumarate (2018)
  • Author(s): Park Haengki、Ohshima Kenji、Nojima Satoshi、Tahara Shinichiro、Kurashige Masako、Hori Yumiko、Okuzaki Daisuke、Wada Naoki、Ikeda Jun-ichiro、Morii Eiichi
  • Journal Title: Lab Invest Volume: in press Issue: 4 Pages: 449-461
  • DOI: 10.1038/s41374-017-0017-0
  • Peer Reviewed / Open Access
• [Journal Article] Enchondromatosis-associated oligodendroglioma: case report and literature review (2017)
  • Author(s): Achiha Takamune、Arita Hideyuki、Kagawa Naoki、Murase Tsuyoshi、Ikeda Jun-ichiro、Morii Eiichi、Kanemura Yonehiro、Fujimoto Yasunori、Kishima Haruhiko
  • Journal Title: Brain Tumor Pathology Volume: 35 Issue: 1 Pages: 36-40
  • DOI: 10.1007/s10014-017-0303-y
  • Peer Reviewed / Open Access
• [Journal Article] Plasma-activated medium (PAM) kills human cancer-initiating cells (2017)
  • Author(s): Ikeda Jun-ichiro、Tanaka Hiromasa、Ishikawa Kenji、Sakakita Hajime、Ikehara Yuzuru、Hori Masaru
  • Journal Title: Pathol Int Volume: 68 Issue: 1 Pages: 23-30
  • DOI: 10.1111/pin.12617
  • Peer Reviewed
• [Journal Article] CUBIC pathology: three-dimensional imaging for pathological diagnosis (2017)
  • Author(s): Nojima Satoshi、Susaki Etsuo A.、Yoshida Kyotaro、Takemoto Hiroyoshi、Tsujimura Naoto、Iijima Shohei、Takachi Ko、Nakahara Yujiro、Tahara Shinichiro、Ohshima Kenji、Kurashige Masako、Hori Yumiko、Wada Naoki、Ikeda Jun-ichiro、Kumanogoh Atsushi、Morii Eiichi、Ueda Hiroki R.
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 9269-9269
  • DOI: 10.1038/s41598-017-09117-0
  • Peer Reviewed / Open Access
• [Journal Article] Non-labeling multiphoton excitation microscopy as a novel diagnostic tool for discriminating normal tissue and colorectal cancer lesions (2017)
  • Author(s): Matsui Takahiro、Mizuno Hiroki、Sudo Takao、Kikuta Junichi、Haraguchi Naotsugu、Ikeda Jun-ichiro、Mizushima Tsunekazu、Yamamoto Hirofumi、Morii Eiichi、Mori Masaki、Ishii Masaru
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 6959-6959
  • DOI: 10.1038/s41598-017-07244-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A small-molecule inhibitor of SMAD3 attenuates resistance to anti-HER2 drugs in HER2-positive breast cancer cells (2017)
  • Author(s): Chihara Yoko、Shimoda Masafumi、Hori Ami、Ohara Ako、Naoi Yasuto、Ikeda Jun-ichiro、Kagara Naofumi、Tanei Tomonori、Shimomura Atsushi、Shimazu Kenzo、Kim Seung Jin、Noguchi Shinzaburo
  • Journal Title: Breast Cancer Res Treat Volume: 166 Issue: 1 Pages: 55-68
  • DOI: 10.1007/s10549-017-4382-6
  • Peer Reviewed
• [Journal Article] Effect of plasma-activated medium on the decrease of tumorigenic population in lymphoma (2017)
  • Author(s): Wada Naoki、Ikeda Jun-ichiro、Tanaka Hiromasa、Sakakita Hajime、Hori Masaru、Ikehara Yuzuru、Morii Eiichi
  • Journal Title: Pathol Res Pract Volume: 213 Issue: 7 Pages: 773-777
  • DOI: 10.1016/j.prp.2017.04.003
  • Peer Reviewed / Open Access
• [Journal Article] Argininosuccinate Synthase 1-Deficiency Enhances the Cell Sensitivity to Arginine through Decreased DEPTOR Expression in Endometrial Cancer. (2017)
  • Author(s): Ohshima K, Nojima S, Tahara S, Kurashige M, Hori Y, Hagiwara K, Okuzaki D, Oki S, Wada N, Ikeda JI, Kanai Y, Morii E.
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 45504-45504
  • DOI: 10.1038/srep45504
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Gnathic giant cell-rich conventional osteosarcoma with MDM2 and CDK4 gene amplification. (2017)
  • Author(s): Hirose K, Okura M, Sato S, Murakami S, Ikeda JI, Noda Y, Fukuda Y, Morii E, Toyosawa S.
  • Journal Title: Histopathology Volume: in press Issue: 7 Pages: 1171-1173
  • DOI: 10.1111/his.13141
  • Peer Reviewed
• [Journal Article] Immunohistochemical analysis of the novel marginal-zone B-cell marker IRTA1 in malignant lymphoma. (2017)
  • Author(s): Ikeda JI, Kohara M, Tsuruta Y, Nojima S, Tahara S, Ohshima K, Kurashige M, Wada N, Morii E.
  • Journal Title: Hum Pathol Volume: 59 Pages: 70-79
  • DOI: 10.1016/j.humpath.2016.09.011
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Comprehensive phenotypic analysis of knockout mice deficient in cyclin G1 and cyclin G2. (2016)
  • Author(s): Ohno S, Ikeda JI, Naito Y, Okuzaki D, Sasakura T, Fukushima K, Nishikawa Y, Ota K, Kato Y, Wang M, Torigata K, Kasama T, Uchihashi T, Miura D, Yabuta N, Morii E, Nojima H.
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 39091-39091
  • DOI: 10.1038/srep39091
  • Peer Reviewed / Open Access
• [Journal Article] S100A4 accelerates the proliferation and invasion of endometrioid carcinoma and is associated with the ‘MELF’ pattern. (2016)
  • Author(s): Tahara S, Nojima S, Ohshima K, Hori Y, Kurashige M, Wada N, Ikeda J, Morii E.
  • Journal Title: Cancer Sci Volume: 109 Issue: 9 Pages: 1345-1352
  • DOI: 10.1111/cas.12999
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Angiogenic Factor with G-patch and FHA Domain 1 (AGGF1) Expression in Human Vascular Lesions (2016)
  • Author(s): Zhan M, Hori Y, Wada N, Ikeda J, Hata Y, Osuga K, Morii E.
  • Journal Title: ACTA HISTOCHEMICA ET CYTOCHEMICA Volume: 49 Issue: 2 Pages: 75-81
  • DOI: 10.1267/ahc.15035
  • NAID: 130005149557
  • ISSN: 0044-5991, 1347-5800
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ID1 upregulation and FoxO3a downregulation by Epstein-Barr virus-encoded LMP1 in Hodgkin lymphoma. (2016)
  • Author(s): Ikeda JI, Wada N, Nojima S, Tahara S, Tsuruta Y, Oya K, Morii E.
  • Journal Title: Mol Clin Oncol Volume: 5 Pages: 562-566
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Therapeutic strategy using non-thermal plasma for cancers targeting cancer-initiating cells (2019)
  • Author(s): Jun-ichiro Ikeda, Hajime Sakakita, Yuzuru Ikehara , Masaru Hori
  • Organizer: ISPlasma2019 / IC-PLANTS2019
  • Int'l Joint Research / Invited
• [Presentation] 子宮類内膜癌におけるがん幹細胞の可塑性に関する検討 (2018)
  • Author(s): 池田 純一郎、浜本 雄一朗、和田 直樹、野島 聡、田原 紳一郎、大島 健司、倉重 真沙子、川崎 桂輔、森井 英一
  • Organizer: 第107回日本病理学会総会
• [Presentation] SDPRは子宮体部類内膜癌の幹細胞性に関わり、上皮間葉転換を促進する (2018)
  • Author(s): 田原 紳一郎、野島 聡、大島 健司、倉重 真沙子、堀 由美子、和田 直樹、池田 純一郎、森井 英一
  • Organizer: 第107回日本病理学会総会
• [Presentation] immunoFISHで探索した異性間骨髄移植後のヒトの二次性腫瘍における癌線維芽細胞とマクロファージの起源 (2018)
  • Author(s): 倉重 真沙子、小原 正治、大島 健司、田原 紳一郎、野島 聡、和田 直樹、池田 純一郎、宮村 耕一、伊藤 雅文、森井 英一
  • Organizer: 第107回日本病理学会総会
• [Presentation] 心移植後にみられた舌平滑筋腫瘍の一例 (2018)
  • Author(s): 本山 雄一、池田 純一郎、堀 由美子、和田 直樹、森井 英一
  • Organizer: 第107回日本病理学会総会
• [Presentation] Chronic expanding hematomaに発生したEpithelioid angiosarcomaの１例 (2018)
  • Author(s): 城光寺 龍、池田 純一郎、森井 英一
  • Organizer: 第107回日本病理学会総会
• [Presentation] SDPRはILKを介して子宮体部類内膜癌の上皮間葉転換を促進する (2018)
  • Author(s): 田原紳一郎，野島聡，大島健司，倉重真沙子，堀由美子，和田直樹，池田純一郎，森井英一
  • Organizer: 第15回日本病理学会カンファレンス
• [Presentation] D-セリン合成酵素Serine racemaseは大腸癌細胞の増殖を促進する (2018)
  • Author(s): 大島健司，野島聡，田原紳一郎，倉重真沙子，川崎桂輔，堀由美子，和田直樹，池田純一郎，森井英一
  • Organizer: 第15回日本病理学会カンファレンス
• [Presentation] リンパ形質細胞性リンパ腫の分化に対してグルタミンが及ぼす効果について (2018)
  • Author(s): 和田直樹，野島聡，田原紳一郎，大島健司，倉重真沙子，川崎桂輔，刀禰充世，楠本真也，池田純一郎，森井英一
  • Organizer: 第15回日本病理学会カンファレンス
• [Presentation] セリンラセマーゼは大腸癌の新たな治療標的となり得る (2018)
  • Author(s): 大島健司、池田純一郎、森井英一
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] 当院の呼吸器EBUS-TBNA 穿刺材料における細胞診検査の現状について (2018)
  • Author(s): 長友忠相，藤埜友稀奈，大西崇文，川嶋真由美，内藤賢郎，野島聡，堀由美子，和田直樹，池田純一郎，森井英一
  • Organizer: 第59回日本臨床細胞学会総会（春期大会）
  • Invited
• [Presentation] LBC法を用いた免疫細胞化学染色によって推定できた乳癌甲状腺転移の一例 (2018)
  • Author(s): 大西崇文，藤埜友稀奈，長友忠相，川嶋真由美，内藤賢郎，野島聡，堀由美子，和田直樹，池田純一郎，森井英一
  • Organizer: 第59回日本臨床細胞学会総会（春期大会）
• [Presentation] 尿中で見られた転移性腫瘍の細胞像 (2018)
  • Author(s): 藤埜友稀奈，長友忠相，大西崇文，川嶋真由美，内藤賢郎，野島聡，堀由美子，和田直樹，池田純一郎，森井英一
  • Organizer: 第59回日本臨床細胞学会総会（春期大会）
• [Presentation] ホジキンリンパ腫におけるプラズマ活性溶液による抗腫瘍効果の検討 (2018)
  • Author(s): 前野悦子，池田純一郎，田原紳一郎，堀由美子，野島聡，和田直樹，森井英一
  • Organizer: 第59回日本臨床細胞学会総会（春期大会）
• [Presentation] 様々なプラズマ照射条件で作製されたプラズマ活性培養液のがん細胞殺傷効果 (2018)
  • Author(s): 内田 儀一郎，池田 純一郎，鈴木 天翔，竹中 弘祐，節原 裕一
  • Organizer: 第79回応用物理学会秋季学術講演会
• [Presentation] プラズマ接触照射で作製したプラズマ活性培養液のがん細胞殺傷効果 (2018)
  • Author(s): 内田 儀一郎，池田 純一郎，鈴木 天翔，竹中 弘祐，節原 裕一
  • Organizer: 第35回プラズマ核融合学会年会
• [Presentation] 神経内分泌への分化を示す乳癌の細胞像について (2018)
  • Author(s): 藤埜友稀奈、大西崇文、長友忠相、川嶋真由美、内藤賢郎、堀由美子、和田直樹、池田純一郎、森井英一
  • Organizer: 第43回臨床細胞学会大阪府支部学術集会
• [Presentation] ANTI-CANCER EFFECT ON CANCER-INITIATING CELLS TREATED WITH PLASMA-ACTIVATED MEDIUM (PAM) IN CANCER CELLS (2017)
  • Author(s): J. Ikeda, H. Tanaka, K. Ishikawa, H. Sakakita, Y. Ikehara, M. Hori
  • Organizer: International Conference on Plasma Medical Science Innovation 2017(ICPMSI2017)
  • Place of Presentation: 名古屋大学
  • Year and Date: 2017-02-27
  • Int'l Joint Research
• [Presentation] ROS and RON production in liquid under the various plasma irradiation conditions (2017)
  • Author(s): G.Uchida, T.Ito, Y.Mino, K.Takenaka, J.Ikeda, Y.Setsuhara
  • Organizer: International Conference on Plasma Medical Science Innovation 2017(ICPMSI2017)
  • Place of Presentation: 名古屋大学
  • Year and Date: 2017-02-27
  • Int'l Joint Research
• [Presentation] CHARACTERIZATION OF ATMOSPHERIC-PRESSURE PLASMA JETS AND INTERACTION WITH LIQUID FOR CONTROL OF REACTIVE SPECIES IN PLASMA-ACTIVATED AQUEOUS SOLUTIONS (2017)
  • Author(s): Yuichi Setsuhara, Giichiro Uchida, Taiki Ito, Junichiro Ikeda,Yusuke Mino, Kosuke Takenaka
  • Organizer: International Conference on Plasma Medical Science Innovation 2017(ICPMSI2017)
  • Place of Presentation: 名古屋大学
  • Year and Date: 2017-02-27
  • Int'l Joint Research
• [Presentation] MECHANISUM OF BLOOD COAGULATION INDUCED BY LOW TEMPERATURE PLASMA TREATMENT (2017)
  • Author(s): Y. Ikehara, S. Ikehara, Y. Akimoto, H. Sakakita, K. Ishikawa, M. Ueda, J. Ikeda, J. Kim, T. Yamaguchi, H. Nakanishi, T. Shimizu, N. Shimizu, M. Hori
  • Organizer: International Conference on Plasma Medical Science Innovation 2017(ICPMSI2017)
  • Place of Presentation: 名古屋大学
  • Year and Date: 2017-02-27
  • Int'l Joint Research
• [Presentation] 子宮内膜細胞診で癌肉腫を推定できた一例 (2017)
  • Author(s): 大西崇文，長友忠相，川嶋真由美，内藤賢郎，堀由美子，和田直樹，池田純一郎，森井英一
  • Organizer: 第42回臨床細胞学会大阪府支部学術集会
  • Place of Presentation: 大阪市立総合医療センター
  • Year and Date: 2017-02-25
• [Presentation] プラズマ照射培養液のリンパ形質細胞性リンパ腫への効果 (2017)
  • Author(s): 和田 直樹、野島 聡、田原 紳一郎、大島 健司、倉重 真沙子、堀 由美子、本間 圭一郎、池田 純一郎、森井 英一
  • Organizer: 第106回日本病理学会総会
• [Presentation] プラズマ活性溶液（PAM）を用いた腫瘍（がん）幹細胞を標的とした抗腫瘍効果の検討 (2017)
  • Author(s): 池田 純一郎、森井 英一
  • Organizer: 第106回日本病理学会総会
• [Presentation] アルギニン合成律速酵素ASS1によるmTORシグナルを介した腫瘍浸潤制御機構 (2017)
  • Author(s): 大島健司，野島聡，田原紳一郎，倉重真沙子，堀由美子，奥崎大介，和田直樹，池田純一郎，森井英一
  • Organizer: 第106回日本病理学会総会
• [Presentation] アルギニン合成律速酵素ASS1によるmTORシグナルを介した腫瘍浸潤制御機構 (2017)
  • Author(s): 大島健司，野島聡，田原紳一郎，倉重真沙子，堀由美子，奥崎大介，和田直樹，池田純一郎，金井好克，森井英一
  • Organizer: 第14回日本病理学会カンファレンス
• [Presentation] ADSLはNK cell receptor分子であるKLRC3の発現制御を介して子宮内膜癌の増殖，浸潤を促進する (2017)
  • Author(s): 大島健司、池田純一郎、森井英一
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 膵EUS-FNAにおけるCellprep検体を用いた免疫細胞化学染色の検討 (2017)
  • Author(s): 大西崇文，長友忠相，川嶋真由美，内藤賢郎，田原紳一郎，野島聡，堀由美子，和田直樹，池田純一郎，森井英一
  • Organizer: 第58回日本臨床細胞学会総会（春期大会）
• [Presentation] 唾液腺導管癌の一例 (2017)
  • Author(s): 前野悦子，堀由美子，野島聡，和田直樹，池田純一郎，森井英一
  • Organizer: 第58回日本臨床細胞学会総会（春期大会）
• [Presentation] 前縦隔腫瘍の一例 (2017)
  • Author(s): 武鑓 美沙，倉重 真沙子，堀 由美子，和田 直樹，池田 純一郎，森井 英一
  • Organizer: 第77回日本病理学会近畿支部学術集会
• [Presentation] 膵腫瘍の一例 (2017)
  • Author(s): 田原 紳一郎，武鑓 美沙，倉重 真沙子，本間 圭一郎，堀 由美子，野島 聡，和田 直樹，池田 純一郎，森井 英一
  • Organizer: 第79回日本病理学会近畿支部学術集会
• [Presentation] 当院でのEUS-FNA検体を用いたLBC標本の免疫細胞化学染色についての検討 (2017)
  • Author(s): 大西崇文，長友忠相，川嶋真由美，内藤賢郎，田原紳一郎，野島聡，堀由美子，和田直樹，池田純一郎，森井英一
  • Organizer: 当院でのEUS-FNA検体を用いたLBC標本の免疫細胞化学染色についての検討
• [Presentation] 穿刺吸引細胞診が有用であった転移性舌腫瘍の1例 (2017)
  • Author(s): 田原 紳一郎, 長友 忠相, 武鑓 美沙, 倉重 真沙子, 本間 圭一郎, 堀 由美子,
  • Organizer: 第32回大阪病理研究会
• [Presentation] 耳下腺腫瘍の1例 (2016)
  • Author(s): 田原 紳一郎，原田 博史，堀 由美子，和田 直樹，野島 聡，池田 純一郎，森井 英一
  • Organizer: 第75回日本病理学会近畿支部学術集会
  • Place of Presentation: 大阪市立大学
  • Year and Date: 2016-12-10
• [Presentation] 乳腺紡錘細胞癌の3例 (2016)
  • Author(s): 前野悦子，吉村英雄，堀由美子．野島聡，和田直樹，池田純一郎，森井英一
  • Organizer: 第55回日本臨床細胞学会秋期大会
  • Place of Presentation: ビーコンプラザ（大分県別府市）
  • Year and Date: 2016-11-18
• [Presentation] Significance of hypoxia and CXCL12-CXCR7 signaling in lymphoplasmacytic lymphoma (2016)
  • Author(s): Naoki Wada, Junichiro Ikeda, Eiichi Morii
  • Organizer: 第78回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-10-14
• [Presentation] S100A4 は子宮内膜癌の増殖と浸潤を促進する (2016)
  • Author(s): 田原紳一郎、池田純一郎、森井英一
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-10-08
• [Presentation] リンパ形質細胞性リンパ腫におけるCXCL12-CXCR7 シグナル (2016)
  • Author(s): 和田直樹、池田純一郎、森井英一
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-10-06
• [Presentation] Swyer症候群の1例 (2016)
  • Author(s): 城光寺龍，辻本正彦，池田純一郎，森井英一
  • Organizer: 第74回日本病理学会近畿支部学術集会
  • Place of Presentation: 関西医科大学
  • Year and Date: 2016-09-17
• [Presentation] Therapeutic approach for cancer-initiating cells with non-thermal plasma: for new medical application (2016)
  • Author(s): Jun-ichiro Ikeda
  • Organizer: Workshop for Current concept for LTP at atmospheric pressure in medical practice
  • Place of Presentation: Munich, Germany
  • Year and Date: 2016-09-10
  • Int'l Joint Research / Invited
• [Presentation] Mechanism of blood coagulation induced by plasma treatment in addition to the acceleration of the natural blood coagulation process (2016)
  • Author(s): Y. Ikehara, S. Ikehara, Y. Akimoto, H. Sakakita, K. Ishikawa, M. Ueda, J. Ikeda, J. Kim, T. Yamaguchi, H. Nakanishi, T. Shimizu, N. Shimizu, M. Hori
  • Organizer: 6th International Conference on Plasma Medicine (ICPM-6)
  • Place of Presentation: Bratislava, Slovakia
  • Year and Date: 2016-09-04
  • Int'l Joint Research
• [Presentation] Effects of surrounding gas flow on ROS and RNS productions in non-thermal plasma-jet system (2016)
  • Author(s): Y. Setsuhara, G. Uchida, T. Ito, A. Nakajima, K. Takenaka, J. Ikeda
  • Organizer: 6th International Conference on Plasma Medicine (ICPM-6)
  • Place of Presentation: Bratislava, Slovakia
  • Year and Date: 2016-09-04
  • Int'l Joint Research
• [Presentation] Effect of plasma-activated medium (PAM) on cancer-initiating cells for cancer therapy (2016)
  • Author(s): J. Ikeda, H. Tanaka, K. Ishikawa, H. Sakakita, M. Hori, Y. Ikehara
  • Organizer: 6th International Conference on Plasma Medicine (ICPM-6)
  • Place of Presentation: Bratislava, Slovakia
  • Year and Date: 2016-09-04
  • Int'l Joint Research
• [Presentation] 左大腿骨病変の一例 (2016)
  • Author(s): 本山雄一，田原紳一郎，辻洋美，野島聡，堀由美子，和田直樹，池田純一郎，森井英一
  • Organizer: 第29回大阪病理研究会
  • Place of Presentation: 大阪大学
  • Year and Date: 2016-07-02
• [Presentation] SPATIO-TEMPORAL BEHAVIORS OF ATMOSPHERIC-PRESSURE PLASMA JETS FOR INVESTIGATION OF REACTIVE-SPECIES PRODUCTION IN LIQUID (2016)
  • Author(s): Y. Setsuhara, A. Nakajima, G. Uchida, T. Ito, K. Takenaka and J. Ikeda
  • Organizer: 43rd IEEE International Conference on Plasma Science, (ICOPS)
  • Place of Presentation: Alberta, Canada
  • Year and Date: 2016-06-19
  • Int'l Joint Research
• [Presentation] Anti-cancer effect of non-thermal plasma on cancer initiating cells: a new medical application for cancer therapy (2016)
  • Author(s): Jun-ichiro Ikeda
  • Organizer: The 19th International Congress of Cytology (ICC 2016)
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-05-29
  • Int'l Joint Research / Invited
• [Presentation] S100A4はMMP-2を介して子宮内膜癌の浸潤を促進する (2016)
  • Author(s): 田原 紳一郎、野島 聡、大島 健司、倉重 真沙子、堀 由美子、和田 直樹、池田 純一郎、森井 英一
  • Organizer: 第105回日本病理学会総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2016-05-13
• [Presentation] 低温大気圧プラズマによる腫瘍（がん）幹細胞を標的としたがん制御の検討 (2016)
  • Author(s): 池田 純一郎、鶴田 陽子、野島 聡
  • Organizer: 第105回日本病理学会総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2016-05-13
• [Presentation] 鼻腔に発生したCD34陰性Solitary fibrous tumorの１例 (2016)
  • Author(s): 城光寺 龍、辻本 正彦、池田 純一郎、森井 英一
  • Organizer: 第105回日本病理学会総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2016-05-13
• [Presentation] リンパ形質細胞性リンパ腫（LPL）におけるCXCL12-CXCR7シグナルの意義 (2016)
  • Author(s): 和田 直樹、池田 純一郎、野島 聡、田原 紳一郎、大島 健司、奥崎 大介、森井 英一
  • Organizer: 第105回日本病理学会総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2016-05-13
• [Presentation] AFP高値を示し多発転移をきたした若年発症卵巣腫瘍の一例 (2016)
  • Author(s): 堀 由美子、武鑓 美沙、野島 聡、和田 直樹、池田 純一郎、森井 英一
  • Organizer: 第105回日本病理学会総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2016-05-12
• [Presentation] THERAPEUTIC APPROACH FOR CANCER-INITIATING CELLS WITH NON-THERMAL PLASMA (2016)
  • Author(s): 池田 純一郎，榊田 創，堀 勝，池原 譲
  • Organizer: The 3rd International Workshop on Plasma For Cancer Treatment (IWPCT2016)
  • Place of Presentation: ワシントンDC (USA)
  • Year and Date: 2016-04-11
  • Int'l Joint Research / Invited
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/molpath/