| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We have focused on CD1a-positive dendritic cells (CD1a-DCs) infiltrating into gallbladder cancer (GBC) tissue and have analyzed the relationships between CD1a-DCs infiltration and clinicopathological factors including prognosis and expressions of mucin core proteins. We found that GBC could be divided into two subgroups. Namely, CD1a-DCs high group which contains many CD1a-DCs or CD1a-DCs low group which contains none or scant CD1a-DCs. CD1a-DCs high group showed favorable prognosis regardless of T- or N-factors. Furthermore, CD1a-DCs infiltration was powerful independent prognostic factor than distant metastasis in the analysis of overall survival. To clarify the mechanism of induction or differentiation CD1a-DCs in GBC tissue would contribute the development of new treatment (such as immunotherapy or molecular targeted therapy) for GBC.
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