Infiltration of CD1a-positive dendritic cells and mucin core protein expression in gallbladder cancer
Project/Area Number |
16K08650
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Saga University |
Principal Investigator |
Kai Keita 佐賀大学, 医学部, 准教授 (60516540)
|
Project Period (FY) |
2016-04-01 – 2019-03-31
|
Project Status |
Completed (Fiscal Year 2018)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 胆嚢癌 / 樹状細胞 / CD1a / 予後因子 / ムチンコア蛋白 / 腫瘍免疫 / 予後予測因子 / CTL / 胆道癌 |
Outline of Final Research Achievements |
We have focused on CD1a-positive dendritic cells (CD1a-DCs) infiltrating into gallbladder cancer (GBC) tissue and have analyzed the relationships between CD1a-DCs infiltration and clinicopathological factors including prognosis and expressions of mucin core proteins. We found that GBC could be divided into two subgroups. Namely, CD1a-DCs high group which contains many CD1a-DCs or CD1a-DCs low group which contains none or scant CD1a-DCs. CD1a-DCs high group showed favorable prognosis regardless of T- or N-factors. Furthermore, CD1a-DCs infiltration was powerful independent prognostic factor than distant metastasis in the analysis of overall survival. To clarify the mechanism of induction or differentiation CD1a-DCs in GBC tissue would contribute the development of new treatment (such as immunotherapy or molecular targeted therapy) for GBC.
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Academic Significance and Societal Importance of the Research Achievements |
胆嚢癌組織中のCD1a陽性樹状細胞浸潤を解析することで、現行のステージングを超えた的確な予後予測実現の可能性がある。癌組織においてCD1a陽性樹状細胞が分化誘導されるメカニズムを解明することにより、進行胆嚢癌の新規治療法の開発 (免疫療法や分子標的療法) に繋がる可能性がある。
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Report
(4 results)
Research Products
(24 results)