Pathological and molecular analysis for moderately differentiated adenocarcinoma of the stomach
| Project/Area Number |
16K08661
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Japanese Foundation for Cancer Research |
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Principal Investigator |
Kawachi Hiroshi 公益財団法人がん研究会, 有明病院 病理部, 部長 (20401375)
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| Co-Investigator(Kenkyū-buntansha) |
山本 智理子 公益財団法人がん研究会, がん研究所 病理部, 副部長 (10280629)
小林 真季 公益財団法人がん研究会, がん研究所 病理部, 研究員 (20599972)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 胃癌 / 中分化腺癌 / 病理 / 免疫染色 / EBV / リンパ節転移 / 横這型 / 病理学 / 消化管 |
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| Outline of Final Research Achievements |
Among tumor groups including predominant moderately differentiated adenocarcinoma, following three groups were mainly evaluated.
(1)Gastric adenocarcinoma with mixed histology group: this group account for 44.5% and the frequency of lymph node metastasis is relatively high compared with other groups. (2)EBV group account for 7.9% and the frequency of lymph node metastasis is significantly higher than non-EBV group. Non-EBV status is an independent risk factor for lymph node metastasis. Moreover, there is no case with lymph node metastasis in the tumors of EBV group without lymphovascular invasion, suggesting that EBV group without lymphovascular invasion can be treated local resection only such as endoscopic submucosal dissection. (3)MSI group account for 7.5% and the frequency of lymph node metastasis is relatively high and there is no significant difference between MSI group and non-MSI group.
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| Academic Significance and Societal Importance of the Research Achievements |
早期胃癌の治療方針を決めるにあたり、高分化、中分化、低分化といった病理組織学的な分化度の判定は現在重要な因子の一つである。ただし、中間的組織像を示す中分化腺癌の判定はしばしば難しく問題となっていた。今回の研究で、中分化腺癌の成分を含む一部の腫瘍群、特にEBV群の場合、分化度の判定を一切行うことなく、脈管侵襲の判定を加えるだけで内視鏡治療の適応が決められる可能性があることがわかった。現在行われている病理組織学的評価に基づく治療方針決定の現状に加え、近年確立されつつある分子分類の要素を臨床応用することが可能でとなれば、個々の患者にとって、より適切な治療方針を選択することに貢献できると期待される。
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Report
(5 results)
Research Products
(10 results)
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[Journal Article] 1. Risk stratification for lymph node metastasis using Epstein-Barr virus status in submucosal invasive (pT1) gastric cancer without lymphovascular invasion: a multicenter observational study.2019
Author(s)
Osumi H, Kawachi H, Murai K, Kusafuka K, Inoue S, Kitamura M, Yoshio T, Kakusima N, Ishihara R, Ono H, Yamamoto N, Sugino T, Nakatsuka S, Ida S, Nunobe S, Bando E, Omori T, Takeuchi K, Fujisaki J
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Journal Title
Gastric Cancer
Volume: -
Issue: 6
Pages: 1176-1182
DOI
Related Report
Peer Reviewed
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[Journal Article] Epstein-Barr virus status is a promising biomarker for endoscopic resection in early gastric cancer: proposal of a novel therapeutic strategy.2019
Author(s)
Osumi H, Kawachi H, Yoshio T, Ida S, Yamamoto N, Horiuchi Y, Ishiyama A, Hirasawa T, Tsuchida T, Hiki N, Takeuchi K, Fujisaki J.
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Journal Title
J Gastroenterol
Volume: -
Issue: 9
Pages: 774-783
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinicopathological features of Siewert type II adenocarcinoma: comparison of gastric cardia adenocarcinoma and Barrett's esophageal adenocarcinoma following endoscopic submucosal dissection.2016
Author(s)
Osumi H, Fujisaki J, Omae M, Shimizu T, Yoshio T, Ishiyama A, Hirasawa T, Tsuchida T, Yamamoto Y, Kawachi H, Yamamoto N, Igarashi M.
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Journal Title
Gastric Cancer
Volume: －
Issue: 4
Pages: 663-670
DOI
Related Report
Peer Reviewed
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