Pathological characteristics of oligometastatic lung cancers

• Project/Area Number: 16K08671
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Yokohama City University
• Principal Investigator: Woo Tetsukan 横浜市立大学, 医学部, 講師 (90537177)
• Co-Investigator(Kenkyū-buntansha): 奥寺 康司 横浜市立大学, 医学部, 准教授 (10326027) ; 荒井 宏雅 横浜市立大学, 医学研究科, 客員講師 (10381493) ; 益田 宗孝 横浜市立大学, 医学研究科, 教授 (10190365) ; 大橋 健一 横浜市立大学, 医学研究科, 教授 (40231203)
• Project Period (FY): 2016-10-21 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 肺癌 / オリゴメタスターシス / 少数個転移

Outline of Final Research Achievements

The purpose of this study was to clarify the pathological characteristics of lung cancers that showed small number of metastases (oligometastasis). As a result of comparing the pathological factors between the oligometastasis and the polymetastasis group, the frequency of the mediastinal lymph node metastasis (N2) cases was significantly high in the polymetastasis group. A comprehensive analysis of tumor microRNA expression was performed using a gene chip microarray, and 20 microRNAs showing differential expression between the oligometastasis and the polymetastasis group were selected. As a result of verifying these expressions by Real-Time PCR, four microRNAs of miR-31-5p, miR-376c-3p, miR-127-3p and miR-150-5p are highly expressed in the oligometastasis group, and it was suggested that the relationship between microRNA expression and oligometastatic lung cancer was shown.

Academic Significance and Societal Importance of the Research Achievements

現在まで、少数個転移（オリゴメタスターシス）肺癌の臨床的特徴を示した報告は複数認めるものの、病理学的特性を示した報告はほとんど認めなかった。本研究で示した腫瘍microRNA発現と少数個転移肺癌との関連性は、今後、多数個転移肺癌との峻別指標の確立に繋がる可能性がある。

Research Products

• [Journal Article] Validating margin status in lung wedge resection for clinical stage I non-small cell lung cancer (2018)
  • Author(s): Sawabata N, Kawase A, Takahashi N, Kawaguchi T, Woo T, Saito Y, Shiono S, Matsutani N; From The International Lung-Clinical-Study Organization (ILO)
  • Journal Title: Surg Today Volume: 48(10) Issue: 10 Pages: 963-967
  • DOI: 10.1007/s00595-018-1683-2
  • Peer Reviewed
• [Journal Article] The potential significance of alpha-enolase (ENO1) in lung adenocarcinomas - A utility of the immunohistochemical expression in pathologic diagnosis. (2017)
  • Author(s): Okudela K, Mitsui H, Matsumura M, Arai H, Shino K, Sekine A, Woo T, Suzuki T, Ishikawa Y, Umeda S, Tajiri M, Masuda M, Ohashi K.
  • Journal Title: Pathol Int. Volume: 67(12) Issue: 12 Pages: 602-609
  • DOI: 10.1111/pin.12607
  • Peer Reviewed / Open Access
• [Journal Article] Does lung cancer surgery cause circulating tumor cells?-A multicenter, prospective study. (2017)
  • Author(s): Matsutani N, Sawabata N, Yamaguchi M, Woo T, Kudo Y, Kawase A, Shiono S, Iinuma H, Morita S, Kawamura M.
  • Journal Title: J Thorac Dis. Volume: 9(8) Issue: 8 Pages: 2419-2426
  • DOI: 10.21037/jtd.2017.07.33
  • Peer Reviewed / Open Access
• [Journal Article] Expression of tropomyosins in lung cancer-a potential role in carcinogenesis and its utility in a histopathological diagnosis. (2016)
  • Author(s): Okudela K, Mitsui H, Woo T, Kojima Y, Matsumura M, Arai H, Suzuki T, Umeda S, Tateishi Y, Saito Y, Tajiri M, Masuda M, Kameda Y, Ohashi K.
  • Journal Title: Histol Histopathol. Volume: 31(8) Pages: 857-66
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Alterations in cathepsin L expression in lung cancers (2016)
  • Author(s): Okudela K, Mitsui H, Woo T, Arai H, Suzuki T, Matsumura M, Kojima Y, Umeda S, Tateishi Y, Masuda M, Ohashi K
  • Journal Title: Pathology international Volume: 66 Issue: 7 Pages: 386-392
  • DOI: 10.1111/pin.12424
  • Peer Reviewed
• [Journal Article] A Histopathological Feature of EGFR-Mutated Lung Adenocarcinomas with Highly Malignant Potential - An Implication of Micropapillary Element. (2016)
  • Author(s): Matsumura M, Okudela K, Kojima Y, Umeda S, Tateishi Y, Sekine A, Arai H, Woo T, Tajiri M, Ohashi K
  • Journal Title: PloS one Volume: 11 Issue: 11 Pages: e0166795-e0166795
  • DOI: 10.1371/journal.pone.0166795
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] EGFR-TKI使用で長期生存に至っている肺癌術後髄膜癌腫症の1例 (2018)
  • Author(s): 禹哲漢
  • Organizer: 第59回 日本肺癌学会学術集会
• [Presentation] 少数個転移（オリゴメタスターシス）を伴った肺癌の臨床病理学的特性に関する後方視的研究 (2018)
  • Author(s): 禹哲漢
  • Organizer: 第10回 International Lung Clinical Research Organization リサーチセミナー
• [Presentation] 肺癌同時単臓器転移の肺切除を含む集学的治療の多施設前向き研究. (2017)
  • Author(s): 禹 哲漢
  • Organizer: 第6回 International Lung Clinical Research Organization リサーチセミナー