| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
We divided teratomas with mucinous tumor components into two groups by STR analysis.One group is that mucinous tumors are derived from teratoma. The other is occurred independently. We studied the difference immunohistochemically. As the result, some intestinal markers are useful for the differentiation. The cellular origin of immature teratoma remains obscure. We performed analysis of STR and studied the cellular origin of immature teratoma. As the result, we found that almost all ovarian immature teratoma had heterozygous pattern. The cellular origin of gliomatosis peritonei (GP) are still unknown suggested as ovarian teratoma cell themselves if not metaplasia of peritoneal or mesenchymal stem cells. We focused on homozygous loci in immature teratomas associated with GP. As the result, our analysis showed GP is not a metaplastic reaction but arises from immature teratoma.
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