Histologial diversity and T-UCR mechansm of gastrointestinal cancer, and their application to clinical practice

• Project/Area Number: 16K08691
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Hiroshima University
• Principal Investigator: Sentani Kazuhiro 広島大学, 医系科学研究科(医), 講師 (30508164)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: T-UCR / Uc.63+ / RCAN2 / Uc.160+ / SPC18 / 病理学

Outline of Final Research Achievements

This study includes the clinicopathological and biological analysis of several T-UCRs such as Uc.416+A, Uc.160+, Uc.63+, Uc.416+A in gastrointestinal or urological cancer. We clarified the machanism of drug-resistance, the effect on other molecules such as miR-153 or PTEN, and the induction of EMT by these T-UCRs. In addition, we showed that claspin and RCAN2 enhance the ability of proliferation and invasiveness, and both of them are poor prognostic factors and play a crucial role in tumor progression.

Academic Significance and Societal Importance of the Research Achievements

本研究では、消化管癌および泌尿器系癌のT-UCRs発現解析に基づいて得られるデータを基盤として、対象とするT-UCRsの発現を制御するmicroRNAや標的とする分子に焦点を当てて解析を行った。得られたデータにより抗がん剤抵抗性を促進する機構やEMTを誘導する機構など予後不良あるいは治療抵抗性を示す癌のメカニズムの一部が明らかにされ、これらの成果は今後さらなる診断、治療への応用が期待される。

Research Products

• [Journal Article] Molecular carcinogenesis of gastric cancer: Lauren classification, mucin phenotype expression, and cancer stem cells. (2019)
  • Author(s): Oue N, Sentani K, Sakamoto N, Uraoka N, Yasui W.
  • Journal Title: Int J Clin Oncol. Volume: 印刷中 Issue: 7 Pages: 771-778
  • DOI: 10.1007/s10147-019-01443-9
  • Peer Reviewed
• [Journal Article] Deficiency of Stomach-Type Claudin-18 in Mice Induces Gastric Tumor Formation Independent of H pylori Infection (2019)
  • Author(s): Suzuki K, Sentani K, Tanaka H, Yano T, Suzuki K, Oshima M, Yasui W, Tamura A, Tsukita S.
  • Journal Title: Cell Mol Gastroenterol Hepatol. Volume: 8 Issue: 1 Pages: 119
  • DOI: 10.1016/j.jcmgh.2019.03.003
  • Peer Reviewed / Open Access
• [Journal Article] Transcribed ultraconserved region Uc.63+ promotes resistance to cisplatin through regulation of androgen receptor signaling in bladder cancer. (2019)
  • Author(s): Sekino Y, Sakamoto N, Ishikawa A, Honma R, Shigematsu Y, Hayashi T, Sentani K, Oue N, Teishima J, Matsubara A, Yasui W.
  • Journal Title: Oncol Rep. Volume: 41 Pages: 3111-3118
  • DOI: 10.3892/or.2019.7039
  • Peer Reviewed / Open Access
• [Journal Article] KIFC1 Inhibitor CW069 Induces Apoptosis and Reverses Resistance to Docetaxel in Prostate Cancer. (2019)
  • Author(s): Sekino Y, Oue N, Koike Y, Shigematsu Y, Sakamoto N, Sentani K, Teishima J, Shiota M, Matsubara A, Yasui W.
  • Journal Title: J Clin Med. Volume: 8 Issue: 2 Pages: 225-225
  • DOI: 10.3390/jcm8020225
  • Peer Reviewed / Open Access
• [Journal Article] Protocadherin B9 promotes resistance to bicalutamide and is associated with the survival of prostate cancer patients. (2019)
  • Author(s): Sekino Y, Oue N, Mukai S, Shigematsu Y, Goto K, Sakamoto N, Sentani K, Hayashi T, Teishima J, Matsubara A, Yasui W.
  • Journal Title: Prostate Volume: 79 Issue: 2 Pages: 234-242
  • DOI: 10.1002/pros.23728
  • Peer Reviewed / Open Access
• [Journal Article] Clinicopathological significance of RCAN2 production in gastric carcinoma. (2019)
  • Author(s): Hattori Y, Sentani K, Shinmei S, Oo HZ, Hattori T, Imai T, Sekino Y, Sakamoto N, Oue N, Niitsu H, Hinoi T, Ohdan H, Yasui W.
  • Journal Title: Histopathology Volume: 74 Issue: 3 Pages: 430-442
  • DOI: 10.1111/his.13764
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinicopathological significance of claspin overexpression and its association with spheroid formation in gastric cancer. (2019)
  • Author(s): Kobayashi G, Sentani K, Hattori T, Yamamoto Y, Imai T, Sakamoto N, Kuraoka K, Oue N, Sasaki N, Taniyama K, Yasui W.
  • Journal Title: Hum Pathol Volume: 84 Pages: 8-17
  • DOI: 10.1016/j.humpath.2018.09.001
  • Peer Reviewed
• [Journal Article] Intramural florid cystic endosalpingiosis of the uterus after menopause. (2018)
  • Author(s): Hattori Y, Sentani K, Matsuoka N, Nakayama H, Hattori T, Kudo Y, Yasui W.
  • Journal Title: Pol J Pathol. Volume: 69 Pages: 321-324
  • Peer Reviewed / Open Access
• [Journal Article] Quiz What is your diagnosis? (2018)
  • Author(s): Hattori Y, Sentani K, Matsuoka N, Nakayama H, Hattori T, Kudo Y, Yasui W.
  • Journal Title: Pol J Pathol. Volume: 69 Pages: 206-206
  • Peer Reviewed / Open Access
• [Journal Article] Uc.416+A promotes epithelial-to-mesenchymal transition through miR-153 in renal cell carcinoma (2018)
  • Author(s): Sekino Yohei、Sakamoto Naoya、Goto Keisuke、Honma Ririno、Shigematsu Yoshinori、Quoc Thang Pham、Sentani Kazuhiro、Oue Naohide、Teishima Jun、Kawakami Fumi、Karam Jose A、Sircar Kanishka、Matsubara Akio、Yasui Wataru
  • Journal Title: BMC Cancer Volume: 18 Issue: 1 Pages: 952-952
  • DOI: 10.1186/s12885-018-4863-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] TDO2 Overexpression Is Associated with Cancer Stem Cells and Poor Prognosis in Esophageal Squamous Cell Carcinoma (2018)
  • Author(s): Pham Quoc Thang、Oue Naohide、Sekino Yohei、Yamamoto Yuji、Shigematsu Yoshinori、Sakamoto Naoya、Sentani Kazuhiro、Uraoka Naohiro、Yasui Wataru
  • Journal Title: Oncology Volume: 95 Issue: 5 Pages: 297-308
  • DOI: 10.1159/000490725
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Preoperative risk classification using neutrophil-lymphocyte ratio and hydronephrosis for upper tract urothelial carcinoma. (2018)
  • Author(s): Kohada Y, Hayashi T, Goto K, Kobatake K, Abdi H, Honda Y, Sentani K, Inoue S, Teishima J, Awai K, Yasui W, Matsubara A.
  • Journal Title: Jpn J Clin Oncol. Volume: 48 Issue: 9 Pages: 841-850
  • DOI: 10.1093/jjco/hyy084
  • Peer Reviewed
• [Journal Article] Tubulocystic renal cell carcinoma: a review of literature focused on radiological findings for differential diagnosis. (2018)
  • Author(s): Honda Y, Nakamura Y, Goto K, Terada H, Sentani K, Yasui W, Sekino Y, Hayashi T, Teishima J, Matsubara A, Akagi M, Fuji T, Baba Y, Iida M, Awai K.
  • Journal Title: Abdom Radiol (NY). Volume: 43 Issue: 7 Pages: 1540-1545
  • DOI: 10.1007/s00261-018-1643-8
  • Peer Reviewed
• [Journal Article] Clinicopathological and Prognostic Significance of Epithelial Gremlin1 Expression in Gastric Cancer. (2018)
  • Author(s): Honma R, Sakamoto N, Ishikawa A, Taniyama D, Fukada K, Hattori T, Sentani K, Oue N, Tanabe K, Ohdan H, Yasui W.
  • Journal Title: Anticancer Res. Volume: 38 Pages: 1419-1425
  • Peer Reviewed
• [Journal Article] Association between histological features of epicardial adipose tissue and coronary plaque characteristics on computed tomography angiography. (2018)
  • Author(s): Senoo A, Kitagawa T, Torimaki S, Yamamoto H, Sentani K, Takahashi S, Kubo Y, Yasui W, Sueda T, Kihara Y
  • Journal Title: Heart Vessels Volume: In press Issue: 8 Pages: 827-836
  • DOI: 10.1007/s00380-018-1129-1
  • Peer Reviewed / Open Access
• [Journal Article] An extremely rare case of Epstein-Barr virus-associated gastric carcinoma with differentiation to neuroendocrine carcinoma. (2018)
  • Author(s): Shimizu A, Takahashi T, Kushima R, Sentani K, Yasui W, Matsuno Y
  • Journal Title: Pathol Int Volume: 68 Issue: 1 Pages: 41-46
  • DOI: 10.1111/pin.12613
  • Peer Reviewed
• [Journal Article] Pseudomesotheliomatous carcinoma of the pleura: an autopsy case of metastasis from a G-CSF-producing anaplastic carcinoma of the pancreas. (2018)
  • Author(s): Hattori Y, Sentani K, Hattori T, Oue N and Yasui W
  • Journal Title: APMIS Volume: 126 Issue: 2 Pages: 166-170
  • DOI: 10.1111/apm.12789
  • Peer Reviewed
• [Journal Article] Tumor Necrosis Factor-α Gene Expression in Epicardial Adipose Tissue is Related to Coronary Atherosclerosis Assessed by Computed Tomography (2018)
  • Author(s): Kitagawa T, Yamamoto H, Hattori T, Sentani K, Takahashi S, Senoo A, Kubo Y, Yasui W, Sueda T, Kihara Y.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 3 Pages: 269-280
  • DOI: 10.5551/jat.41178
  • NAID: 130006407160
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Clinicopathological and prognostic significance of epithelial Gremlin1 expression in gastric cancer. (2018)
  • Author(s): Honma R, Sakamoto N, Ishikawa A, Taniyama D, Fukada K, Hattori T, Sentani K, Oue N, Tanabe K, Ohdan H, Yasui W
  • Journal Title: Anticancer Res Volume: 38 Issue: 3 Pages: 1419-1425
  • DOI: 10.21873/anticanres.12366
  • Peer Reviewed
• [Journal Article] Overexpression of the Transmembrane Protein IQGAP3 Is Associated with Poor Survival of Patients with Gastric Cancer. (2017)
  • Author(s): Oue N, Yamamoto Y, Oshima T, Asai R, Ishikawa A, Uraoka N, Sakamoto N, Sentani K, Yasui W.
  • Journal Title: Pathobiology Volume: - Issue: 3 Pages: 192-200
  • DOI: 10.1159/000481890
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Transcribed ultraconserved region Uc.63+ promotes resistance to docetaxel through regulation of androgen receptor signaling in prostate cancer. (2017)
  • Author(s): Sekino Y, Sakamoto N, Goto K, Honma R, Shigematsu Y, Sentani K, Oue N, Teishima J, Matsubara A and Yasui W
  • Journal Title: Oncotarget Volume: 8 Issue: 55 Pages: 94259-94270
  • DOI: 10.18632/oncotarget.21688
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Overexpression of KIFC1 and its association with spheroid formation in esophageal squamous cell carcinoma. (2017)
  • Author(s): Imai T, Oue N, Yamamoto Y, Asai R, Uraoka N, Sentani K, Yoshida K, Yasui W.
  • Journal Title: Pathol Res Pract Volume: 213 Issue: 11 Pages: 1388-1393
  • DOI: 10.1016/j.prp.2017.09.009
  • Peer Reviewed
• [Journal Article] Combination therapy using molecular-targeted drugs modulates tumor microenvironment and impairs tumor growth in renal cell carcinoma. (2017)
  • Author(s): Kitano H, Kitadai Y, Teishima J, Yuge R, Shinmei S, Goto K, Inoue S, Hayashi T, Sentani K, Yasui W, Matsubara A.
  • Journal Title: Cancer Med Volume: 6 Issue: 10 Pages: 2308-2320
  • DOI: 10.1002/cam4.1124
  • Peer Reviewed / Open Access
• [Journal Article] Chronic kidney disease as a risk factor for recurrence and progression in patients with primary non-muscle-invasive bladder cancer. (2017)
  • Author(s): Kobatake K, Hayashi T, Black PC, Goto K, Sentani K, Kaneko M, Yasui W, Mita K, Teishima J, Matsubara A.
  • Journal Title: Int J Urol Volume: 24 Issue: 8 Pages: 594-600
  • DOI: 10.1111/iju.13389
  • Peer Reviewed
• [Journal Article] Overexpression of the transmembrane protein BST-2 induces Akt and Erk phosphorylation in bladder cancer. (2017)
  • Author(s): Shigematsu Y, Oue N, Nishioka Y, Sakamoto N, Sentani K, Sekino Y, Mukai S, Teishima J, Matsubara A, Yasui W.
  • Journal Title: Oncol Lett Volume: 14 Issue: 1 Pages: 999-1004
  • DOI: 10.3892/ol.2017.6230
  • Peer Reviewed / Open Access
• [Journal Article] A comparison of clinicopathological features and prognosis in prostate cancer between atomic bomb survivors and control patients. (2017)
  • Author(s): Shoji K, Teishima J, Hayashi T, Shinmei S, Akita T, Sentani K, Takeshima Y, Arihiro K, Tanaka J, Yasui W, Matsubara A.
  • Journal Title: Oncol Lett Volume: 14 Issue: 1 Pages: 299-305
  • DOI: 10.3892/ol.2017.6119
  • Peer Reviewed / Open Access
• [Journal Article] Overexpression of PCDHB9 promotes peritoneal metastasis and correlates with poor prognosis in patients with gastric cancer. (2017)
  • Author(s): Mukai S, Oue N, Oshima T, Imai T, Sekino Y, Honma R, Sakamoto N, Sentani K, Kuniyasu H, Egi H, Tanabe K, Yoshida K, Ohdan H, Yasui W.
  • Journal Title: J Pathol Volume: 243 Issue: 1 Pages: 100-110
  • DOI: 10.1002/path.4931
  • Peer Reviewed / Open Access
• [Journal Article] The Expression of BTS-2 Enhances Cell Growth and Invasiveness in Renal Cell Carcinoma. (2017)
  • Author(s): Pham QT, Oue N, Yamamoto Y, Shigematsu Y, Sekino Y, Sakamoto N, Sentani K, Uraoka N, Tiwari M, Yasui W.
  • Journal Title: Anticancer Res Volume: 37 Issue: 6 Pages: 2853-2860
  • DOI: 10.21873/anticanres.11637
  • Peer Reviewed
• [Journal Article] Imaging features of papillary renal cell carcinoma with cystic change-dominant appearance in the era of the 2016 WHO classification. (2017)
  • Author(s): Honda Y, Goto K, Nakamura Y, Terada H, Sentani K, Yasui W, Sekino Y, Hayashi T, Teishima J, Matsubara A, Fuji T, Kaichi Y, Higaki T, Baba Y, Iida M, Awai K.
  • Journal Title: Abdom Radiol (NY) Volume: 42 Issue: 7 Pages: 1850-1856
  • DOI: 10.1007/s00261-017-1189-1
  • Peer Reviewed
• [Journal Article] Expression and function of Uc.160+, a transcribed ultraconserved region, in gastric cancer. (2017)
  • Author(s): Honma R, Goto K, Sakamoto N, Sekino Y, Sentani K, Oue N, Yasui W.
  • Journal Title: Gastric Cancer Volume: 20 Issue: 6 Pages: 960-969
  • DOI: 10.1007/s10120-017-0714-9
  • NAID: 40021377334
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Characteristic expression of fukutin in gastric cancer among atomic bomb survivors. (2017)
  • Author(s): Pham TT, Oue N, Yamamoto M, Fujihara M, Ishida T, Mukai S, Sakamoto N, Sentani K, Yasui W.
  • Journal Title: Oncol Lett Volume: 13 Issue: 2 Pages: 937-941
  • DOI: 10.3892/ol.2016.5520
  • Peer Reviewed / Open Access
• [Journal Article] Long-term follow-up study of gastric adenoma; tumor-associated macrophages are associated to carcinoma development in gastric adenoma. (2017)
  • Author(s): Taniyama D, Taniyama K, Kuraoka K, Zaitsu J, Saito A, Nakatsuka H, Sakamoto N, Sentani K, Oue N, Yasui W.
  • Journal Title: Gastric Cancer Volume: 20 Issue: 6 Pages: 929-939
  • DOI: 10.1007/s10120-017-0713-x
  • NAID: 40021377278
  • Peer Reviewed
• [Journal Article] BRAFV600E cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis. (2017)
  • Author(s): Sakamoto N, Feng Y, Stolfi C, Kurosu Y, Green M, Lin J, Green ME, Sentani K, Yasui W, McMahon M, Hardiman KM, Spence JR, Horita N, Greenson JK, Kuick R, Cho KR, Fearon ER.
  • Journal Title: Elife Volume: 6 Pages: 6-6
  • DOI: 10.7554/elife.20331
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] KIF11 Is Required for Spheroid Formation by Oesophageal and Colorectal Cancer Cells. (2017)
  • Author(s): Imai T, Oue N, Sentani K, Sakamoto N, Uraoka N, Egi H, Hinoi T, Ohdan H, Yoshida K, Yasui W.
  • Journal Title: Anticancer Res Volume: 37 Issue: 1 Pages: 47-55
  • DOI: 10.21873/anticanres.11287
  • Peer Reviewed
• [Journal Article] Clinicopathological significance of SPC18 in colorectal cancer: SPC18 participates in tumor progression. (2017)
  • Author(s): Hattori T, Sentani K, Naohide O, Sakamoto N, Yasui W
  • Journal Title: Cancer Science Volume: 108(1) Issue: 1 Pages: 143-150
  • DOI: 10.1111/cas.13121
  • Peer Reviewed / Open Access
• [Journal Article] KIFC1 induces resistance to docetaxel and is associated with survival of prostate cancer patients (2017)
  • Author(s): Sekino Y, Oue N, Shigematsu Y, Ishikawa A, Sakamoto N, Sentani K, Teishima J, Matsubara A, Yasui W
  • Journal Title: Urologic Oncology Volume: 35 Issue: 1 Pages: 13-31
  • DOI: 10.1016/j.urolonc.2016.08.007
  • Peer Reviewed / Open Access
• [Journal Article] Regeneration of rat corpora cavernosa tissue by transplantation of CD133+ cells derived from human bone marrow and placement of biodegradable gel sponge sheet. (2017)
  • Author(s): Inoue S, Miyamoto K, Shinmei S, Shoji K, Teishima J, Sentani K, Yasui W, Matsubara A.
  • Journal Title: Asian J Androl Volume: 19 Issue: 2 Pages: 203-207
  • DOI: 10.4103/1008-682x.179155
  • Peer Reviewed / Open Access
• [Journal Article] KIF11 Is Required for Spheroid Formation by Oesophageal and Colorectal Cancer Cells. (2017)
  • Author(s): Imai T, Oue N, Sentani K, Sakamoto N, Uraoka N, Egi H, Hinoi T, Ohdan H, Yoshida K, Yasui W.
  • Journal Title: Anticancer Res. Volume: 37 Pages: 47-55
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Overexpression of KIF11 in gastric cancer with intestinal mucin phenotype (2016)
  • Author(s): Imai T, Oue N, Nishioka M, Mukai S, Oshima T, Sakamoto N, Sentani K, Matsusaki K, Yoshida K, Yasui W
  • Journal Title: Pathobiology Volume: 84 Issue: 1 Pages: 16-24
  • DOI: 10.1159/000447303
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Overexpression of transmembrane protein BST2, participating in cell growth, is associated with poor survival in patients with esophageal, gastric and colorectal cancer (2016)
  • Author(s): Mukai S, Oue N, Oshima T, Tatsumoto Y, Sakamoto N, Sentani N, Hinoi T, Ohdan H, Yasui W
  • Journal Title: Annals of Surgical Oncology Volume: 24 Issue: 2 Pages: 594-602
  • DOI: 10.1245/s10434-016-5100-z
  • Peer Reviewed / Open Access
• [Journal Article] Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation (2016)
  • Author(s): Miguchi M, Hinoi T, Shimomura M et al
  • Journal Title: PloS One Volume: 11 Issue: 11 Pages: 0166422-0166422
  • DOI: 10.1371/journal.pone.0166422
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Clinicopathologic characteristics and management of minute esophageal lesions diagnosed by narrow-band imaging endoscopy. (2016)
  • Author(s): Kumamoto T, Sentani K, Oka S, Tanaka S, Yasui W.
  • Journal Title: Endosc Int Open. Volume: 4 Issue: 09 Pages: 927-932
  • DOI: 10.1055/s-0042-110788
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Intrahepatic cholangiocarcinoma coinciding with a liver metastasis from a rectal carcinoma: a case report. (2016)
  • Author(s): Akabane S, Ohira M, Kobayashi T, Kuroda S, Tanimine N, Shimizu S, Tahara H, Ide K, Ishiyama K, Egi H, Tanabe K, Sentani K, Yasui W, and Ohdan H.
  • Journal Title: Surg Case Rep Volume: 2 Issue: 1 Pages: 94-94
  • DOI: 10.1186/s40792-016-0222-x
  • Peer Reviewed / Open Access
• [Journal Article] Pure invasive micropapillary carcinoma of the esophagogastric junction with lymph nodes and liver metastasis. (2016)
  • Author(s): Hattori T, Sentani K, Hattori Y, Oue N, Yasui W.
  • Journal Title: Pathol Int. Volume: 66 Issue: 10 Pages: 583-586
  • DOI: 10.1111/pin.12450
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] KRAS mutation leads to decreased expression of regulator of calcineurin 2, resulting in tumor proliferation in colorectal cancer. (2016)
  • Author(s): Niitsu H, Hinoi T, Kawaguchi Y, Sentani K, Yuge R, Kitadai Y, Sotomaru Y, Adachi T, Saito Y, Miguchi M, Kochi M, Sada H, Shimomura M, Oue N, Yasui W, Ohdan H.
  • Journal Title: Oncogenesis. Volume: 5 Issue: 8 Pages: 8-8
  • DOI: 10.1038/oncsis.2016.47
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Increased Calcineurin A Expression Is Associated with a Lower Relapse-Free Survival Rate after Colorectal Cancer Surgery. (2016)
  • Author(s): Niitsu H, Hinoi T, Sentani K, Mukai S, Adachi T, Saito Y, Miguchi M, Kochi M, Sada H, Oue N, Yasui W, Ohdan H.
  • Journal Title: Pathobiology Volume: 83 Issue: 6 Pages: 308-15
  • DOI: 10.1159/000445121
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Balloon Cell Malignant Melanoma in a Young Female: A Case Report and Review of the Literature. (2016)
  • Author(s): Hattori Y, Sentani K, Hattori T, Matsuo Y, Kawai M, Shindo H, Tanaka M, Hide M, Yasui W.
  • Journal Title: Case Rep Oncol. Volume: 27 Issue: 1 Pages: 262-266
  • DOI: 10.1159/000446065
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Induction of KIFC1 expression in gastric cancer spheroids (2016)
  • Author(s): Oue N, Mukai S, Imai T, Trang TBP, Oshima T, Sentani K, Sakamoto N, Yoshida K, Yasui W
  • Journal Title: Oncology Reports Volume: 36 Issue: 1 Pages: 349-355
  • DOI: 10.3892/or.2016.4781
  • Peer Reviewed / Open Access
• [Journal Article] Regulation of multidrug resistance 1 expression by CDX2 in ovarian mucinous adenocarcinoma. (2016)
  • Author(s): Koh I, Hinoi T, Sentani K, Hirata E, Nosaka S, Niitsu H, Miguchi M, Adachi T, Yasui W, Ohdan H, Kudo Y.
  • Journal Title: Cancer Med Volume: 5 Issue: 7 Pages: 1546-55
  • DOI: 10.1002/cam4.697
  • Peer Reviewed / Open Access
• [Journal Article] A case of tubulocystic carcinoma of the kidney with aggressive features. (2016)
  • Author(s): Maeda Y, Goto K, Honda Y, Kuroda N, Sentani K, Yasui W, Hayashi T, Teishima J, Matsubara A, Nakamura Y, Toyota N, Iida M, Awai K.
  • Journal Title: Jpn J Radiol. Volume: 34 Issue: 4 Pages: 307-311
  • DOI: 10.1007/s11604-016-0525-7
  • NAID: 50009787736
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] ALKR1275Q perturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN. (2016)
  • Author(s): Ueda T, Nakata Y, Yamasaki N, Oda H, Sentani K, Kanai A, Onishi N, Ikeda K, Sera Y, Honda ZI, Tanaka K, Sata M, Ogawa S, Yasui W, Saya H, Takita J, Honda H.
  • Journal Title: Oncogene. Volume: 無 Issue: 34 Pages: 4447-4458
  • DOI: 10.1038/onc.2015.519
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Regression of Cecal MALT Lymphoma after Antibiotic Treatment in a Patient with <i>Helicobacter pylori</i> Infection (2016)
  • Author(s): Yuge R, Kitadai Y, Tanaka S, Uraoka N, Sentani K, Yasui W, Chayama K.
  • Journal Title: Internal Medicine Volume: 55 Issue: 2 Pages: 135-139
  • DOI: 10.2169/internalmedicine.55.5937
  • NAID: 130005119765
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Mouse model of proximal colon-specific tumorigenesis driven by microsatellite instability-induced Cre-mediated inactivation of Apc and activation of Kras. (2016)
  • Author(s): Kawaguchi Y, Hinoi T, Saito Y, Adachi T, Miguchi M, Niitsu H, Sasada T, Shimomura M, Egi H, Oka S, Tanaka S, Chayama K, Sentani K, Oue N, Yasui W, Ohdan H.
  • Journal Title: J Gastroenterol. Volume: 51 Issue: 5 Pages: 447-457
  • DOI: 10.1007/s00535-015-1121-9
  • Peer Reviewed / Open Access
• [Journal Article] Fukutin, identified by the Escherichia coli ampicillin secretion trap (CAST) method, participates in tumor progression in gastric cancer. (2016)
  • Author(s): Oo HZ, Sentani K, Mukai S, Hattori T, Shinmei S, Goto K, Sakamoto N, Naito Y, Anami K, Trang PT, Yanagihara K, Oue N, Yasui W.
  • Journal Title: Gastric Cancer Volume: 19 Issue: 2 Pages: 443-452
  • DOI: 10.1007/s10120-015-0511-2
  • NAID: 40020835493
  • Peer Reviewed / Open Access
• [Journal Article] The transcribed-ultra conserved regions in prostate and gastric cancer: DNA hypermethylation and microRNA-associated regulation. (2015)
  • Author(s): Keisuke Goto, Sho Ishikawa,Ririno Honma, Keiji Tanimoto, Naoya Sakamoto,Kazuhiro Sentani, Naohide Oue, Jun Teishima, Akio Matsubara and Wataru Yasui.
  • Journal Title: Oncogene Volume: 1 Issue: 27 Pages: 1-1
  • DOI: 10.1038/onc.2015.445
  • Peer Reviewed / Open Access
• [Journal Article] TSPAN8, identified by Escherichia coli ampicillin secretion trap, is associated with cell growth and invasion in gastric cancer (2015)
  • Author(s): Katsuhiro Anami, Naohide Oue, Tsuyoshi Noguchi, Naoya Sakamoto, Kazuhiro Sentani, Tetsutaro Hayashi, Yutaka Naito, Htoo Zarni Oo, Wataru Yasui
  • Journal Title: Gastric Cancer Volume: ahead of print Issue: 2 Pages: 370-380
  • DOI: 10.1007/s10120-015-0478-z
  • Peer Reviewed / Open Access
• [Presentation] Retrospective clinicopathologic review of gastric cancer in Rwanda-Friendship collaboration study. (2018)
  • Author(s): Nagai S, Mugenzi P, Sentani K, Ingabire C, Akintije AC, Sugimura H, Yasui W, Rugwizangoga B, Musoni E, Sinayobye JD, Nyst JF, Reuck MD, Muvunyi ZT, Rwamasirabo E, Kalengayi MR
  • Organizer: 第90回日本胃癌学会総会
• [Presentation] 胃癌の組織学的多様性と癌関連分子との相関． (2018)
  • Author(s): 仙谷和弘、今井健晴、服部拓也、服部 結、谷山大樹、石川 洸、坂本直也、大上直秀、安井 弥
  • Organizer: 第107回日本病理学会総会
• [Presentation] Continuous gastric acid leakage due to dysfunctional paracellular-barrier function causes gastric tumor via CXCL5 and Wnt signaling with age. (2018)
  • Author(s): Suzuki K, Sentani K, Tanaka H, Yano T, Suzuki K, Yasui W, Tamura A and Tsukita S
  • Organizer: 第91回日本生化学会大会
• [Presentation] 胃癌の組織学的多様性と特徴的な癌関連遺伝子． (2018)
  • Author(s): 仙谷和弘、今井健晴、服部拓也、服部 結、谷山大樹、石川 洸、勝矢脩嵩、城戸 綾、坂本直也、大上直秀、安井 弥
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] Transcribed ultraconserved region Uc.63+ promotes resistance to docetaxel through regulation of androgen receptor signaling in prostate cancer. (2018)
  • Author(s): Sekino Y, Sakamoto N, Goto K, Honma R, Shigematsu Y, Oue N, Sentani K, Teishima J, Yasui W and Matsubara A
  • Organizer: European Association of Urology Annual Meeting 2018
  • Int'l Joint Research
• [Presentation] Expression analysis of transcribed-ultraconserved regions in cancer stem cell population using colorectal cancer organoids. (2018)
  • Author(s): Honma R, Sakamoto N, Ishikawa A, Taniyama D, Fukada K, Sekino Y, Mukai S, Sentani K, Oue N, Hinoi T, Egi H, Ohdan H and Yasui W
  • Organizer: The 109th Annual Meeting of the American Association for Cancer Research
  • Int'l Joint Research
• [Presentation] Pten haploinsufficiency promotes tumor invasion and carcinogenesis in mouse colon epithelium with Apc deficiency. (2018)
  • Author(s): Sada H, Hinoi T, Niitsu H, Kovhi M, Sakamoto N, Sentani K, Oue N, Yasui W and Ohdan H
  • Organizer: The 109th Annual Meeting of the American Association for Cancer Research
  • Int'l Joint Research
• [Presentation] Uc.416+A promotes epithelial-to-mesenchymal transition through miR-153 in renal cell carcinoma. (2018)
  • Author(s): Sekino Y, Thang PQ, Honma R, Shigematsu Y, Sakamoto N, Sentani K, Oue N, Teishima J, Yasui W and Matsubara A
  • Organizer: The 35th Korea-Japan Urological Congress
  • Int'l Joint Research
• [Presentation] Histological diversity and clinicopathological significance in mucosal and invasive areas of gastric cancer (2017)
  • Author(s): 仙谷和弘、今井健晴、服部拓也、服部 結、谷山 大樹、石川 洸、山本 悠司、本間りりの、坂本直也、大上直秀、安井 弥
  • Organizer: 第89回日本胃癌学会総会
  • Place of Presentation: 広島
  • Year and Date: 2017-03-08
• [Presentation] 胃癌における粘膜内と浸潤部の組織学的多様性と臨床病理学的意義． (2017)
  • Author(s): 仙谷和弘、今井健晴、服部拓也、服部 結、谷山大樹、石川 洸、山本悠司、本間りりの、坂本直也、大上直秀、安井 弥
  • Organizer: 第89回日本胃癌学会総会
• [Presentation] 胃癌のかたち・性格の多様性と遺伝子レベルの変化． (2017)
  • Author(s): 仙谷和弘
  • Organizer: 第22回日本胃癌学会市民公開講座
  • Invited
• [Presentation] 胃癌における粘膜内と浸潤部の組織像の比較と臨床病理学的意義． (2017)
  • Author(s): 仙谷和弘、今井健晴、服部拓也、服部 結、谷山大樹、石川 洸、山本悠司、本間りりの、坂本直也、大上直秀、安井 弥
  • Organizer: 第106回日本病理学会総会
• [Presentation] 胃癌の組織学的多様性と癌関連分子の相関． (2017)
  • Author(s): 仙谷和弘、今井健晴、服部拓也、服部 結、谷山大樹、勝矢脩嵩、石川 洸、坂本直也、大上直秀、安井 弥
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] CAST法によって同定したFukutinは胃癌の進展に寄与する． (2016)
  • Author(s): 仙谷和弘、Zarni Oo Htoo、向井正一朗、服部拓也、後藤景介、坂本直也、PT Trang、今井健晴、大上直秀、安井 弥
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-06
• [Presentation] 広島県腫瘍登録における唾液腺腫瘍の解析. (2016)
  • Author(s): 仙谷和弘、小川郁子、小笹晃太郎、定金敦子、歌田真衣、野間 純、山田博康、津谷隆史、梶原博毅、米原修治、武島幸男、安井 弥
  • Organizer: 地域がん登録全国協議会第25回学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2016-06-02
• [Presentation] CAST法によって同定されたFukutinの腸型粘液形質胃癌における臨床病理学的意義． (2016)
  • Author(s): 仙谷和弘、Htoo Zarni Oo、向井正一朗、服部拓也、後藤景介、坂本直也、Pham Thi Binh Trang、今井健晴、大上直秀、安井 弥
  • Organizer: 第105回日本病理学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-05-12
• [Remarks] 広島大学大学院医系科学研究科分子病理学
  • URL: https://home.hiroshima-u.ac.jp/byori1/index.html
• [Remarks] 広島大学大学院医歯薬保健学研究科分子病理学研究室
  • URL: http://home.hiroshima-u.ac.jp/byori1/
• [Remarks] 広島大学大学院医歯薬保健学研究科分子病理学研究室
  • URL: http://home.hiroshima-u.ac.jp/byori1/index.html