Molecular epidemiological study of radiation-induced childhood thyroid cancer

• Project/Area Number: 16K08702
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Department of Clinical Research, National Hospital Organization Nagasaki Medical Center
• Principal Investigator: Ito Masahiro 独立行政法人国立病院機構(長崎医療センター臨床研究センター), 臨床研究センター, 機能形態研究部長 (30184691)
• Co-Investigator(Kenkyū-buntansha): サエンコ ウラジミール 長崎大学, 原爆後障害医療研究所, 准教授 (30343346) ; 中島 正洋 長崎大学, 原爆後障害医療研究所, 教授 (50284683)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 甲状腺癌 / 小児甲状腺癌 / 放射線被曝 / チェルノブイリ原発事故 / 福島原発事故 / チェルノブイリ / 分子疫学 / 発がん / 小児 / 放射線 / 病理学 / 遺伝子 / 環境

Outline of Final Research Achievements

The histopathological features of 348 spontaneous papillary thyroid carcinomas in Japan and Ukraine were analyzed (Endocr J 2017). The examination items were sex ratio, tumor size, pT, histopathology, tumor component, cell morphology, background, nodule count, lymph node metastasis, distant metastasis, etc. Comparison was made according to age group (under 15 years old, 15-19 years old). A similar pathological analysis was performed on 115 papillary thyroid carcinomas (Fukushima Medical University case) under the age of 18 at the time of the accident discovered and operated at screening in Fukushima Prefecture (Cancer Sci 2019). In the case of Fukushima, the tendency between the groups was compared in the period (4 years before 4 years, 2 groups of 4 years or more) and the age at the time of surgery (3 groups under 15 years, 15-19 years, 19 years or older).

Academic Significance and Societal Importance of the Research Achievements

福島第一原発事故後の若年発症甲状腺癌とチェルノブイリ原発事故後に激増した小児甲状腺癌の病理形態学的な比較、本邦の自然発症性若年者甲状腺癌とチェルノブイリ周辺地域の自然発症性若年者甲状腺癌の比較がなされたことはなく、本研究課題は独自性の高いと云える。
本研究から期待される成果は以下の4点にある。1. 地域や環境の差が病理形態学的所見や遺伝子変異に与える影響の解明。2.低線量被曝関連の若年者甲状腺発癌機構の解明。福島第一原発事故後に発見された若年者甲状腺癌と低線量被曝の因果関係の解明。3. 若年者の自然発症性甲状腺がんの発症機序の解明。4.原子力発電所事故時の防護を考える上での基礎的なデータとなる。

Research Products

• [Int'l Joint Research] キエフ内分泌研究所(ウクライナ)
• [Int'l Joint Research]
• [Journal Article] Histopathological analysis of papillary thyroid carcinoma detected during ultrasound screening examinations in Fukushima (2019)
  • Author(s): Suzuki Shinichi、Bogdanova Tetiana I.、Saenko Vladimir A.、Hashimoto Yuko、Ito Masahiro、Iwadate Manabu、Rogounovitch Tatiana I.、Tronko Mykola D.、Yamashita Shunichi
  • Journal Title: Cancer Science Volume: 110 Issue: 2 Pages: 817-827
  • DOI: 10.1111/cas.13912
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparative Histopathologic Analysis of “Radiogenic” and “Sporadic” Papillary Thyroid Carcinoma: Patients Born Before and After the Chernobyl Accident (2018)
  • Author(s): Bogdanova Tetiana I.、Saenko Vladimir A.、Brenner Alina V.、Zurnadzhy Liudmyla Yu.、Rogounovitch Tatiana I.、Likhtarov Ilya A.、Masiuk Sergii V.、Kovgan Leonila M.、Shpak Victor M.、Thomas Geraldine A.、Chanock Stephen J.、Mabuchi Kiyohiko、Tronko Mykola D.、Yamashita Shunichi
  • Journal Title: Thyroid Volume: 28 Issue: 7 Pages: 880-890
  • DOI: 10.1089/thy.2017.0594
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genetic Polymorphism Predisposing to Differentiated Thyroid Cancer: A Review of Major Findings of the Genome-Wide Association Studies (2018)
  • Author(s): Saenko Vladimir A.、Rogounovitch Tatiana I.
  • Journal Title: Endocrinology and Metabolism Volume: 33 Issue: 2 Pages: 164-164
  • DOI: 10.3803/enm.2018.33.2.164
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lessons from Fukushima: Latest Findings of Thyroid Cancer After the Fukushima Nuclear Power Plant Accident. (2018)
  • Author(s): Yamashita S, Suzuki S, Suzuki S, Shimura H, Saenko V.
  • Journal Title: Thyroid Volume: 28 Issue: 1 Pages: 11-22
  • DOI: 10.1089/thy.2017.0283
  • NAID: 120006987977
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mouse models of sporadic thyroid cancer derived from BRAFV600E alone or in combination with PTEN haploinsufficiency under physiologic TSH levels. (2018)
  • Author(s): Shimamura M, Shibusawa N, Kurashige T, Mussazhanova Z, Matsuzaki H, Nakashima M, Yamada M, Nagayama Y
  • Journal Title: PloS one Volume: 13 Issue: 8 Pages: e0201365-e0201365
  • DOI: 10.1371/journal.pone.0201365
  • NAID: 120006987838
  • Peer Reviewed / Open Access
• [Journal Article] Sporadic pediatric papillary thyroid carcinoma harboring the ETV6/NTRK3 fusion oncogene in a 7-year-old Japanese girl: a case report and review of literature. (2018)
  • Author(s): Otsubo R, Mussazhanova Z, Akazawa Y, Sato A, Matsuda K, Matsumoto M, Yano H, Matsuse M, Mitsutake N, Ando T, Niino D, Nagayasu T, Nakashima M.
  • Journal Title: Endocrinol Metab Volume: 31 Issue: 4 Pages: 461-467
  • DOI: 10.1515/jpem-2017-0292
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Comparative histopathological analysis of sporadic pediatric papillary thyroid carcinoma from Japan and Ukraine (2017)
  • Author(s): Bogdanova TI, Saenko VA, Hirokawa M, Ito M, Zurnadzhy LY, Hayashi T, Rogounovitch TI, Miyauchi A, Tronko MD, Yamashita S.
  • Journal Title: Endocrine Journal Volume: 64 Issue: 10 Pages: 977-993
  • DOI: 10.1507/endocrj.EJ17-0134
  • NAID: 130006186081
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Papillary thyroid carcinoma with desmoid-type fibromatosis: A clinical, pathological, and immunohistochemical study of 14 cases (2017)
  • Author(s): Takada N, Hirokawa M, Ito M, Ito A, Suzuki A, Higuchi M, Kuma S, Hayashi T, Kishikawa M, Horikawa S, Miyauchi A.
  • Journal Title: Endocrine Journal Volume: 64 Issue: 10 Pages: 1017-1023
  • DOI: 10.1507/endocrj.EJ17-0242
  • NAID: 130006186073
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cytogenetic biodosimetry and dose-rate effect after radioiodine therapy for thyroid cancer. (2017)
  • Author(s): Khvostunov IK, Saenko VA, Krylov V, Rodichev A, Yamashita S.
  • Journal Title: Radiat Environ Biophys Volume: 56 Issue: 3 Pages: 213-226
  • DOI: 10.1007/s00411-017-0696-3
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Genotype Analyses in the Japanese and Belarusian Populations Reveal Independent Effects of rs965513 and rs1867277 but Do Not Support the Role of FOXE1 Polyalanine Tract Length in Conferring Risk for Papillary Thyroid Carcinoma. (2017)
  • Author(s): Nikitski AV, Rogounovitch TI, Bychkov A, Takahashi M, Yoshiura KI, Mitsutake N, Kawaguchi T, Matsuse M, Drozd VM, Demidchik Y, Nishihara E, Hirokawa M, Miyauchi A, Rubanovich AV, Matsuda F, Yamashita S, Saenko VA.
  • Journal Title: Thyroid Volume: 27 Issue: 2 Pages: 224-235
  • DOI: 10.1089/thy.2015.0541
  • NAID: 120006987557
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparative histopathological analysis of pediatric sporadic papillary thyroid carcinoma from Japan and Ukraine. (2017)
  • Author(s): Bogdanova T, Saenko V, Hirokawa M, Ito M, Zurnadzhy L, Hayashi T, Rogounovitch T, Miyauchi A, Tronko M, Yamashita S.
  • Journal Title: Endocr J Volume: in press
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Meeting report: the 5th International expert symposium in Fukushima on radiation and health. (2017)
  • Author(s): Saenko VA, Thomas GA, Yamashita S.
  • Journal Title: Environ Health. Volume: 16 Issue: 1 Pages: 3-3
  • DOI: 10.1186/s12940-017-0211-y
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Expression of Somatostatin Receptor Type 2A and PTEN in Neuroendocrine Neoplasms Is Associated with Tumor Grade but Not with Site of Origin. (2016)
  • Author(s): Wada H, Matsuda K, Akazawa Y, Yamaguchi Y, Miura S, Ueki N, Kinoshita A, Yoshiura K, Kondo H, Ito M, Nagayasu T, Nakashima M.
  • Journal Title: Endocr Pathol. Volume: 27(3) Issue: 3 Pages: 179-187
  • DOI: 10.1007/s12022-016-9436-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between p53-binding protein 1 expression and genomic instability in oncocytic follicular adenoma of the thyroid (2016)
  • Author(s): Mussazhanova Z, Akazawa Y, Matsuda K, Shichijo K, Miura S, Otsubo R, Oikawa M, Yoshiura K, Mitsutake N, Rogounovitch T, Saenko V, Kozykenova Z, Zhetpisbaev B, Shabdarbaeva D, Sayakenov N, Amntayev B, Kondo H, Ito M, Nakashima M.
  • Journal Title: Endocrine Journal Volume: 63 Issue: 5 Pages: 457-467
  • DOI: 10.1507/endocrj.EJ15-0629
  • NAID: 130005154197
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Targeted Foxe1 overexpression in mouse thyroid causes the development of multinodular goiter but does not promote carcinogenesis. (2016)
  • Author(s): Nikitski A, Saenko V, Shimamura M, Nakashima M, Matsuse M, Suzuki K, Rogounovitch T, Bogdanova T, Shibusawa N, Yamada M, Nagayama Y, Yamashita S, Mitsutake N
  • Journal Title: Endocrinology Volume: 印刷中 Issue: 5 Pages: 2182-2195
  • DOI: 10.1210/en.2015-2066
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] チェルノブイリ組織バンク －19年間の活動状況と課題－ (2018)
  • Author(s): 伊東 正博, Tetiana Bogdanova, Niena Dvinskykh, Guido Fadda, Jeniffer Hunt, Gerry Thomas, 中島 正洋, 山下 俊一
  • Organizer: 第107回 日本病理学会総会
• [Presentation] 日本甲状腺病理学会共同企画1：診療に難渋した甲状腺・副甲状腺症例の検討 甲状腺低分化癌の1例 (2017)
  • Author(s): 伊東正博,松本佳子
  • Organizer: 第50回甲状腺外科学会
• [Presentation] 甲状腺乳頭癌から放射線治療後に未分化転化した一剖検例 (2017)
  • Author(s): 上木 望, 黒濱 大和, ムサジャノバ ジャンナ, 松田 勝也, 三浦 史郎, 重野 里代子, 田中 藤信, 伊東 正博, 中島 正洋
  • Organizer: 第106回日本病理学会総会
• [Presentation] 甲状腺の病理細胞診と小児甲状腺がんの病理 (2017)
  • Author(s): 伊東正博
  • Organizer: 甲状腺超音波検査講習会
  • Invited
• [Presentation] チェルノブイリの甲状腺癌 [シンポジウム5 小児甲状腺癌」 (2016)
  • Author(s): 伊東正博
  • Organizer: 第55回日本臨床細胞学会秋季大会
  • Place of Presentation: 別府
  • Year and Date: 2016-11-18
  • Invited
• [Presentation] 「放射線発がんの腫瘍登録への病理医の貢献」 シンポジウム8 がん登録、実務からデーター活用まで (2016)
  • Author(s): 伊東正博
  • Organizer: 第105回日本病理学会
  • Place of Presentation: 仙台
  • Year and Date: 2016-05-12
  • Invited
• [Presentation] 甲状腺の病理組織と細胞診像、放射線と甲状腺癌 (2016)
  • Author(s): 伊東 正博
  • Organizer: 甲状腺超音波検査講習会
  • Place of Presentation: 郡山
  • Invited
• [Book] 癌診療指針のための病理診断プラクティス 内分泌腫瘍 甲状腺,副腎 (2018)
  • Author(s): 伊東正博
  • Publisher: 中山書店