| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
The Akt phosphorylation site amino acid sequence Thr-Ser-Thr (864-866) of human Inversin is conserved in higher animals such as primates, but not in animal groups such as mice, frogs and zebrafish. There was no effect on intracellular localization of Inversin or Wnt signal inhibitory activity. Thus, there would be no functional conservation of Inversin phosphorylation by Akt. Moreover, Inversin was found to be accumulated in some nuclear structure which likely to be a transcriptional activation center and has a specific transcription activity. Taken together, this study strongly suggests that Inversin functions as a novel transcriptional regulator.
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