| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
CADM1 is an adhesion molecule expressed abundantly in neurons and epithelial cells. We have revealed that ectodomain shedding of CADM1 is occurred in emphysema, interstitial pneumonia and diabetes and that CADM1 shedding leads to cell apoptosis. In this study, to elucidate pathogenic action of CADM1 shedding in neurodegeneration, we investigated the correlation between enteric nerve degeneration and CADM1 shedding in dilated colon with tumor-induced stenosis. CADM1 shedding rate was increased proportionately with colon dilation in association with decrease of ganglion cells and neurites. Using two-chamber cell culture system enable to loading modest static pressure to the cultured cells, we showed that increasing pressure induced CADM1 shedding and the decreases of neurite density and thickness. Exogenous expression of CADM1 shedding product resulted in neurites loss, suggesting its involvement in neurodegeneration.
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