| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Basophilia is a frequently observed hematological abnormality in chronic myeloid leukemia (CML), but its pathophysiological roles are undefined. In this study, we demonstrated that basophil-like leukemia cells proliferate and constitutively express an inflammatory chemokine, CCL3, in the bone marrow of mice developing CML. Moreover, CCL3 preferentially inhibits the proliferation of normal hematopoietic stem/progenitor cells, thereby facilitating the dominant proliferation of leukemia stem cells during the initiation process of CML development. We further demonstrated that the depletion of basophil-like leukemia cells or the oral-administration of CCL3 inhibitor efficiently prevented the CML development.
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